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Biomedical subjects

I McColl

Publications and source records attributed to I McColl.

At least 91 records · Page 5Linked to original sources
PubMed1976

Audit of audit.

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Economics, Hospital↗
PubMed1976

Communication as a method of medical audit.

Advances in the practice of medicine over the past forty years have rendered informal communication ineffective in setting and maintaining standards of clinical care. In the past five years, four methods in communication have been introduced in the department of surgery at Guy's Hospital: problem-oriented medical records, death-and-complications meetings, unit review meetings, and a clinical information service. It is suggested that these can achieve quality control.

Communication↗
PubMed1976

Avascular necrosis of bone in patients undergoing renal allotransplantation.

Five to forty-three months after renal allotranplantation, thirteen patients (9 male, 4 female) developed avascular necrosis of one or more joints. The dose of corticosteroids used as part of the immunosuppressive therapy was compared to that used in similar patients who did not develop avascular necrosis. No significant difference could be found.

Adolescent↗
PubMed1975

Short-term cadaver kidney preservation.

200 consecutive human cadaver kidneys were preserved using 6 different techniques. Some attempt was made in the clinical situation to assess donor pre-treatment and postoperative specific recipient treatment to encourage immediate renal function. Provided the warm time was less than 60 min and the cold time less than 12 hours, intraarterial flushing with a crystalloid or colloid solution combined with pre-treatment of the donor and postoperative fluid load/frusemide drive to the recipient gave the best results.

Cadaver↗
PubMed1975

Stimulation of water and sodium secretion and inhibition of glucose absorption from the rat jejunum during intraarterial infusions of prostglandins.

The effect of prostaglandins, isoprenaline and dibutyryl cyclic adenosine monophosphate (dibut cAMP) on the net transfer of water and Na+ and glucose absorption have been studied in the anaesthetized rat. The lumen of the jejunum was recirculated with a solution of normal saline containing D (+) glucose and phenosulphonphthalein. The superior mesenteric artery was perfused extracorporeally and drugs were infused into the arterial blood. Prostaglandin E1 (PGE1) at infusion rates of 2-5 X 10(-9) and 10(-8) mol/min induced a net secretion of water and Na+ which was significantly different from the infused control mean. Both water and Na+ secretion were dose-related. PGE1 induced slight but significant inhibition of glucose absorption at 10(-8) mol/min. This could either be a direct effect or secondary to solvent drag. PGE2 (2-5 X 10(-9) mol/min) and PGF2alpha (8 X 10(-9) mol/min) induced water and Na+ secretion, and inhibited glucose absorption but not significantly. Isoprenaline (10(-9) mol/min) and dibut cAMP (8 X 10(-9) mol/min) did not alter water, Na+ or glucose absorption.

Animals↗
PubMed1973

Hydrothorax after central venous catheterization.

Three patients are described who developed hydrothorax as a complication of central venous catheterization. Respiratory distress associated with physical signs of fluid in the chest should arouse suspicion that the venous catheter has perforated the wall of the vein.The complications of central venous catheterization are reviewed and three cases of hydrothorax are presented. Comments on the prevention of these complications, their diagnosis and treatment if they occur, are made.

Adolescent↗
PubMed1973

Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine.

Small intestinal samples were obtained by intubation from multiple sites along the small intestine in 11 subjects with no known gastrointestinal disease eating a normal diet and at laparotomy in a further three subjects. Free (unconjugated) bile acids were consistently demonstrated in ileal samples, and occasionally in lower jejunal samples, by thin-layer chromatography, supplemented in some cases by gas/liquid chromatography and by infrared spectroscopy. The free bile acid concentration, measured enzymically following thin-layer chromatography, reached a maximum (1 mM) in the lower ileum, where it represented half the total bile acid concentration. Following ampicillin, the concentration of free bile acids decreased markedly, suggesting that they resulted from bacterial deconjugation; at the same time the total bile acid concentration increased, suggesting impaired absorption due to the reduced concentration of the more rapidly absorbed free bile acids. Our results indicate that the presence of free bile acids in lower jejunal and ileal samples is a normal finding, and cannot be taken as evidence of abnormal bacterial overgrowth. They also suggest that bacterial deconjugation at these sites may be a factor contributing to the remarkable efficiency of bile salt reabsorption.

Adult↗