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Biomedical subjects

I Mattiasson

Publications and source records attributed to I Mattiasson.

At least 73 records · Page 4Linked to original sources
PubMed1985

The relation between in vitro efflux of noradrenaline from platelets and vas deferens in man.

The efflux of isotope-labelled noradrenaline from platelets and vas deferens was compared in 29 healthy males. Platelets and a preparation of tissue from vas deferens were incubated with isotope-labelled noradrenaline until equilibrium in the uptake was obtained. The spontaneous efflux of noradrenaline in buffer was measured for 20 min. There was a significant positive correlation between the efflux of noradrenaline from platelets and vas deferens (r = 0.56, P less than 0.001).

Adult↗
PubMed1985

Design, findings and five-year follow-up of preventive medical lipid intervention clinic in Malmö.

In a separate lipid intervention clinic integrated within the framework of a multiphasic preventive medical population program in Malmö, 401 of 2431 screening attenders in a male birth-year cohort born in 1927 and 1928 had elevated values of triglyceride and/or cholesterol. Hypertriglyceridemia was more than three times as frequent as hypercholesterolemia. Of these attenders 20% had normal values at the second control, 5% did not attend the second test and 92 (31.2%) of the remaining were referred to other clinics because of other high risk factors. Thus, 209 (8.6% of the screening attenders) males born in 1927 and 1928 attended the lipid clinic for isolated hyperlipidemia. Disregarding a 5-year drop-out frequency of 13 sections, a significant reduction in the lipids was obtained during the follow-up period in those remaining in treatment. This study demonstrates the feasibility in taking care of hyperlipidemic individuals after a screening detection program. Detection and treatment of hyperlipidemia should of course also be initiated in the individual case in ordinary medical practice.

Cholesterol↗
PubMed1984

Self-reported family history of hypertension in healthy middle-aged men.

A self-reported first-degree family history of hypertension was obtained by questionnaire in two consecutive subsamples of middle-aged male attenders to a multi-phased health screening program in Malmö. This corresponded to 2739 men in lower (36-39 years) and 6597 in upper (46-48 years) middle age. Reported first-degree family history of hypertension was very frequent, about 26-27% in both groups. It was predominantly confined to the parental generation and was twice as common in mother as in father. Furthermore, the reported family histories showed marked interrelations. Thus, hypertension was much more frequently reported when both parents had the condition than if it only concerned one of them. It is proposed that these findings may reflect an increased awareness, investigation, diagnosis and treatment of hypertension rather than the genetic occurrence of the disease per se in modern society.

Adult↗
PubMed1984

Blood pressure and other risk factors in healthy middle-aged men in relation to self-reported first-degree family history of hypertension.

In a questionnaire-assessed first-degree family history of hypertension obtained in a sizable subsample of middle-aged male attenders to a multiphasic health screening programme in Malmö, the actual blood pressure distributions and other risk factors are compared in the different heredity groups. Both mean values and frequencies of borderline and hypertensive levels of the systolic and diastolic blood pressures were significantly higher in groups with a family history of hypertension in particular biparental, than in those without. Reported paternal hypertension was less frequent than reported maternal hypertension but resembled more the biparental history group in terms of the recorded blood pressure levels. Several biochemical and physiological variables were compared between the groups, but there were no differences in associated risk factors, including blood lipids, except for higher serum urate in the biparental history group than in the others. Only part of the overrepresentation of increased blood pressure levels that was present appeared to be of the genuine idiopathic variety of hypertension, and the genotype for this disorder did not appear to be associated with other risk factors for hypertension in the population.

Blood Pressure↗
PubMed1984

[Carcinoma and leukoplakia in the oral cavity in relation to AHH induction, smoking and dental status].

Smoking habits, dental status and aryl-hydrocarbonhydroxylase (AHH) inducibility were studied in a series of 52 oral leucoplakias and 20 oral cancers. There was an obvious association between leucoplakia, cancer and smoking. A significant overrepresentation of high AHH and a corresponding underrepresentation of low AHH inducibility were found among the smokers with leucoplakia and in the oral carcinoma group. In both groups, however, the dental status was largely normal.

Adult↗
PubMed1983

Efflux of granule constituents from platelets exposed to different mechanical forces.

The efflux of 14C-norepinephrine, 3H-serotonin and beta-thromboglobulin from platelets was compared with the extent of lysis in two different systems of incubation, in which Ca2+ and conventional platelet activating agents were omitted. In the first system platelets were incubated in buffer at 37 degrees C and gently shaken. Cell lysis was low and efflux of 14C-norepinephrine was 71-97% of total initial uptake after 24 hours. In the other system rotating plastic tubes at 20 degrees C were used which exposed the platelets to higher mechanical stress. Cell lysis and aggregation was already high after 10-30 minutes, but the efflux of 14C-norepinephrine and 3H-serotonin was lower and not parallel to cell lysis. The release of 14C-norepinephrine was higher than that of 3H-serotonin in both systems. There was a considerable release of beta-thromboglobulin from platelets remaining in plasma despite of a constant pH. These findings indicate that platelet lysis is independent of the release of platelet granule constituents.

Blood Platelets↗
PubMed1982

Effects of thrombin, acetyl salicylic acid and prostaglandins on spontaneous efflux of norepinephrine and beta-thromboglobulin from platelets in calcium/magnesium deficient environment.

The effect of different substances on the spontaneous efflux of 14C-norepinephrine (14C-NE) and beta-thromboglobulin (beta TG) from platelets in Ca2+ - and Mg2+ - free buffer was tested. Addition of increasing concentrations of thrombin (0.015-0.625 U/ml) resulted in an immediate increase of 14C-NE detectable in the supernatants, but the slopes of the efflux curves from 10 min after thrombin addition were almost identical and parallel with the slope before thrombin addition. Also beta-thromboglobulin was steadily released after thrombin addition. Prostaglandin E1 and prostacyclin in concentrations that gave a 30-fold increase in cAMP accumulation resulted in a moderate decrease in efflux of 14C-NE from 10 to 30 min but did not influence the efflux thereafter up to 80 min. Acetyl salicylic acid in vivo and in vitro (200-500 mumol/l) did not influence the efflux of 14C-NE or beta TG. The conclusions are that factors known to exert considerable effects on aggregation, desaggregation and acute release produce only transitory effects in a Ca2+ - and Mg2+ - free environment and that the basal efflux of alpha-granule components seems to be a stable process.

Alprostadil↗
PubMed1982

Spontaneous efflux of platelet alpha-granule components in relation to 14C-norepinephrine in buffers.

In an investigation of the spontaneous efflux of beta-thromboglobulin (beta-TG), 14C-norepinephrine (14C-NE) and growth stimulating activity (GSA), measured as incorporation of 3H-thymidine in rabbit aortic smooth cells, from platelets resuspended in Ca++- and Mg++-free buffer a continuous increase in 3H-thymidine incorporation was seen during 120 min. There was good stoichiometric parallelism between beta-TG and 14C-NE during the 80 minutes the experiment lasted, indicating that norepinephrine is incorporated in alpha-granules and release by exocytosis.

Animals↗
PubMed1982

Efflux of noradrenaline from platelets in normotensive members of hypertensive families.

1. Platelets have been used as a model of sympathetic neurons to study the storage of noradrenaline in normotensive individuals belonging to families with essential hypertension for at least two generations. 2. The initial efflux rate (k) of noradrenaline was determined in 44 young relatives (mean age 29.2 years), in 18 middle-aged relatives (mean age 46.7 years) and in 31 young controls with no known family history of essential hypertension (mean age 29.8 years). From the groups of relatives all those with definite hypertension had been excluded a priori. 3. k was significantly higher in the young relatives (22.7 +/- 7.9) than in the middle-aged relatives (17.7 +/- 6.4) and in the controls (15.6 +/- 5.1). Of the relatives 27.3% had higher k values than any of the controls. A significant correlation was found between k and diastolic blood pressure in controls but not in young relatives.

Adult↗
PubMed1981

Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status.

The authors investigated the smoking patterns in a consecutive series of 20 patients with oral cancer and at the same time assessed the aryl hydrocarbon hydroxylase (AHH) inducibility distribution and dental status. The AHH level proved high in 8 patients, intermediate in 7 and low in 5. High AHH inducibility was more common (p = less than 0.001) and low AHH inducibility less common (p = less than 0.001) than in the controls. Dental status was poor in only 2 patients. It is concluded that smoking is a prominent exogenous factor associated with the occurrence of cancer in the oral cavity. Poor dental status seems to be of minor importance.

Adult↗
PubMed1981

Net efflux rate of norepinephrine from platelets in normotensive individuals belonging to families with a heavy accumulation of essential hypertension.

Platelets have been used as a model of sympathetic neurons to study the storage of norepinephrine in normotensive individuals who all had a first degree relative with essential hypertension and had hypertension in the family for at least two generations. The initial rate of efflux of norepinephrine, k, was determined in 44 young relatives (mean age 29.2 years), in 18 middle-aged relatives (mean age 46.7 years) and in 31 young controls with no known family history of essential hypertension (mean age 29.8 years). From the material of relatives all those with definite hypertension had been a priori excluded. k was significantly higher in the young relatives (22.7 +/- 7.9) than in the middle-aged relatives (17.7 +/- 6.4) (p less than 0.05). 27.3% of the relatives had higher k-values than any of the controls. A significant correlation was found between k-value and diastolic blood pressure in controls but not in young relatives.

Adult↗