Hermansky-Pudlak syndrome and factor VIII ristocetin cofactor.
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Biomedical subjects
Publications and source records attributed to I Mackie.
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In 35 patients undergoing routine orthopaedic operations in which occlusive tourniquets were used there was a pronounced rise in fibrinolytic activity in the systemic circulation which lasted for at least 15 minutes after the release of the tourniquet; this response was seen after operations on both arms and legs. In contrast there was no increase in fibrinolytic activity in the systemic circulation associated with venous occlusion. Neither the application of a tourniquet nor venous occlusion resulted in changes in factors V or VIII, fibrinogen, or platelet-count. The application of a completely occlusive tourniquet might be a simple form of prophylaxis against deep-vein thrombosis and would avoid the disadvantages of using heparin.
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Applying the principles of therapeutic milieu, in which individual needs can be recognised within those of a group, can help people with dementia to realise their potential. The implementation of a system of care based on such an approach in a day unit is described, focusing on the need to acknowledge the essential worth of attenders and providing adequate support for staff.