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Biomedical subjects

I M Mendeleev

Publications and source records attributed to I M Mendeleev.

At least 19 recordsLinked to original sources
PubMed1991

[A severe course of autoimmune thrombocytopenia and the procedure for its treatment in systemic lupus erythematosus].

The authors describe three comparatively rare cases of extremely severe symptomatic autoimmune thrombocytopenia associated with systemic lupus erythematosus. The use of glucocorticoids in large doses and in two cases of splenectomy turned out ineffective. The next therapeutic measures are suggested in the following succession: glucocorticoids----cytostatic drugs (vincristine)----splenectomy to be performed only in special cases.

Acute Disease↗
PubMed1991

[Results of 16-year use of the 06-Paris-LA-66 program in the treatment of children with acute lymphoblastic leukemia].

The treatment of children with acute lymphoblastic leukemia was conducted with the use of 06-Paris-LA-66 program modified by the authors. Complete remission was obtained in 91.8% of cases. Recovery was achieved and the therapy was discontinued in 16 out of 34 patients who had strictly adhered the program treatment, the treatment of 7 patients in complete remission is continued. The authors consider the program as high efficient and recommend its use.

Adolescent↗
PubMed1990

[The efficacy of treatment using expanded programs of megavolt irradiation and polychemotherapy in patients with lymphogranulomatosis in stages I, II and IIIA].

The authors relate the results of multimodality treatment of 90 patients with stages I-IIIA lymphogranulomatosis. The total survival amounted to 86.4 +/- 3.8% within the time exceeding 7 years. The efficacy of the treatment of patients with lymphogranulomatosis of different stages by using multi-beam and broad-beam radiation is under comparison. The data obtained indicate that total radiation of lymph nodes in patients with stage II lymphogranulomatosis is not advisable.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

[Roentgenoradiological and ultrasonic diagnosis of liver and spleen involvement in patients with Hodgkin's disease].

A combined study including selective angiography of the liver and spleen, angioscintigraphy with 99mTc-TCK-5, polypositional scintigraphy with 99mTc-frosstimag-phytate, and ultrasonic scanning was conducted to detect specific liver and splenic involvement in 57 patients with Hodgkin's disease, CT was performed in 4 patients. A high diagnostic value of all methods was shown in macronodal liver involvement (node sizes over 3 cm); of ultrasonic scanning--in the detection of nodes in the liver (node sizes from 1 to 3 cm); of ultrasonic scanning, angiography and angioscintigraphy--in nodal splenic involvement. Signs of diffuse-infiltrative liver involvement detected in angiography and angioscintigraphy were described. The informative value of ultrasonic scanning and CT in this type of involvement was much lower.

Adolescent↗
PubMed1988

[The importance of studying the acid phosphatase of the blood serum and bone marrow lymphoblasts and polymorphonuclear neutrophils in the prognosis of the course of acute lymphoblastic leukemia].

The activity of serum acid phosphatase (AP), bone marrow lymphoblasts and polymorphonuclear neutrophils was studied in 45 ALL patients. Cytochemical coefficients (CCC) and the percentage of positively reacting bone marrow cells were determined. All the patients received programmed polychemotherapy. They were investigated before the start of therapy, during recurrence and at different time of remission (from 1 to 60 mos) during each reinduction cycle. At the climax of ALL the activity of serum AP was increased 2.8-fold, a CCC value for lymphoblastic AP--10-fold, for polymorphonuclear neutrophils--3-fold as compared with normal values. A tendency toward the reduction of indices was noted at different time of remission, the approximation to normal values was noted on the 40th-46th months of remission only. In recurrence development the level of the serum and cellular enzyme as well as the percentage of positively reacting cells significantly exceeded normal values and were close to indices at the climax of disease. The above tendency permitted the use of these tests to evaluate the completeness of remission and to predict recurrences during a follow-up of ALL patients.

Acid Phosphatase↗
PubMed1988

[Radiodiagnosis of recurrences of lymphogranulomatosis].

The authors discuss the role and place of chest x-ray tomography, scintigraphy with 67Ga-citrate, ultrasonic investigation, angiography, angioscintigraphy, computed tomography, scintigraphy of the liver and bones in the diagnosis of recurrences of Hodgkin's disease and in control of a progress of disease. Indications for a successive use of one or the other method have been defined.

Bone Neoplasms↗
PubMed1988

[Postradiation hypothyroidism in patients with lymphogranulomatosis].

A total of 93 patients with Hodgkin's disease were investigated at different times after radiation therapy. The hypothyroid status was found in 21.7% of the patients. The influence of the patients' age at the time of irradiation, administration of iodine-containing contrast drugs, polychemotherapy, and a summary focal dose of thyroid irradiation on the frequency of development of postradiation hypothyrosis was discussed. Criteria for substitution therapy with thyroid hormones were defined.

Adolescent↗
PubMed1987

[Acid phosphatase of leukocytes in patients with diffuse toxic goiter in evaluating the stage of the disease].

Acid phosphatase (AP) of lymphocytes and neutrophils was examined cytochemically in 23 patients with associated diffuse toxic goiter (DTG) and thyrotoxicosis during thiamazol treatment, in 20 persons with a DTG remission, and in 5 patients with postradiation and postoperative hypothyroses. AP activity with multiple-granule distribution of the enzyme was high in the majority of the patients with thyrotoxicosis, decreasing with thiamazol treatment. Thyrotoxicosis recurred in 4 out of 11 patients whose lymphocytes had an increased amount of AP during a DTG remission. In 9 patients with normal AP content, no relapses were noted during a DTG remission. Two patients with iatrogenic hypothyroses associated with high lymphocytic AP activity manifested elevated titres of antithyroglobulin immunoglobulins (ATI). In 3 patients with normal content of cellular AP, the ATI titre was low. Cellular AP, a non-specific marker of immunogenesis activity, makes it possible to presumably differentiate the stages of DTG and to evaluate to a definite degree the character of a remission. The preserved high activity of lymphocytic AP in patients with a DTG remission is a prognostically unfavourable factor as regards thyrotoxicosis relapses. The high titre of ATI and activity of lymphocytic AP attest to the predominant autoimmune component of such hypothyroses in part of DTG patients. The authors stress that such patients should receive combined thyroid and glucocorticoid therapy.

Acid Phosphatase↗
PubMed1986

[Results of splenectomy with polychemotherapy in the treatment of 15 chronic myeloid leukemia patients].

The results of splenectomy followed by chemotherapy are analysed. Fifteen patients with chronic myeloid leukemia (CML) were entered into the study. The maximal survival of one of the patients subjected to splenectomy was 102 months. The authors come to the conclusion that it is desirable that CML patients should be subjected to splenectomy after preliminary preparation (chemotherapy and chemoprotectors) at the early stages of the illness, which is to be followed by monochemotherapy. Provided the latter is unsuccessful, the change over to polychemotherapy similar to the treatment protocols for myeloid leukemia is suggested.

Adult↗
PubMed1986

[Automation of renographic studies using a microcomputer].

The paper is concerned with the results of the automation of renogram storage and processing. The computer system 15 VUMS-28 (on the basis of the ELEKTRONIKA-60 computer) fitted out with storage on the magnetic tape (KML) AZII-4, two 3-channel renographs (NP-356 and NP-307), manufactured in Hungary, and a plotter N-306 were interfaced by means of the KAMAK apparatus. The REN-1 program in the QUASIC language ensuring simultaneous storage and processing of renograms from two renographs was developed. The maximum time (Tmax) and semiexcretion time (T 1/2) as well as a system of indicators based on a linear chamber model of hippuran transport were used for analysis of renograms.

Computers↗
PubMed1985

[Use of cytosar (cytosine arabinoside) in the control of herpetic complications in patients with acute leukemia and lymphogranulomatosis].

The authors report the use of the cytostatic drug cytosar in the control of herpetic complications in patients with acute leukemia and lymphogranulomatosis. A distinct effect was obtained as a result of intravenous drip of cytosar in a dose of 0.03-0.05 g for 2 days. It is desirable that cytosar therapy may be instituted within the first days of the development of herpetic infection.

Adolescent↗
PubMed1985

[Irradiation of lymphogranulomatosis patients with large fields of complex configuration, calculating absorbed doses by microcomputer].

The authors demonstrated advantages of irradiating lymphogranulomatosis patients with large fields of complex configuration. The use of computer eliminates the difficulties of dosage calculation. Application for these purposes of the 15 VUMS-28 unit based on the microcomputer "Elektronika-60" is suggested. Algorithm of the dosage calculation program is presented. The program is drawn up according to the GOST so that it can be used by other institutions concerned.

Cobalt Radioisotopes↗
PubMed1984

[Effectiveness of radiotherapy in patients with lymphogranulomatosis depending on the stage of the disease].

The authors review variants of radiotherapy of patients with lymphogranulomatosis. Regard the method of irradiation with broad fields of complicated configuration as preferable. Point to the advisability of using one or another method depending on the disease stage. Describe the conditions necessary, in their opinion, for successful radiotherapy of lymphogranulomatosis patients.

Hodgkin Disease↗