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Biomedical subjects

I M Markelov

Publications and source records attributed to I M Markelov.

At least 19 recordsLinked to original sources
PubMed1997

[Pulmonary hypertension and myocardial contraction in disseminated types of pulmonary tuberculosis].

To elucidate the influence of hemodynamic factors on the development of right ventricular failure, hemodynamic parameters of the lesser and greater circulations and those characterizing myocardial contractility were studied in 36 patients. Despite profuse lung damage, pulmonary failure, and marked external respiration dysfunction that accompanied disseminated pulmonary tuberculosis, pulmonary hypertension was moderate and failed to be followed by hemodynamic overload, right cardiac hypertrophy and dilatation. Significant reductions in myocardial contractility both of the right and left cavities with a rise in the intensity of an inflammatory process suggest the leading role of a toxic and infectious agent in myocardial damage.

Cardiac Output↗
PubMed1982

[Lactate dehydrogenase activity and isoenzyme spectrum in the transplanted sensory and sympathetic ganglia of the rat].

Total activity, isoenzyme pattern of lactate dehydrogenase (LDH), morphological peculiarities of normal and transplanted in the mesentery for 1-7 and 30 days dorsal root and superior cervical sympathetic ganglia of the adult rats, were analysed. About 30% neurons in sensory ganglia and 5% in sympathetic ganglia were viable 30 days after transplantation. Total LDH activity was 3 times higher in normal sympathetic ganglia compared with that in spinal ganglia. Transplantation leads to a slight rising in total LDH activity in sensory root ganglia and to a slight fall in sympathetic ganglia. Five fractions of LDH in normal sensory ganglia and four fractions in sympathetic ganglia were revealed. Significant rising of M4 isoenzyme activity was characteristic of both sensory and sympathetic ganglia after transplantation for 7 days. Functional significance of the changes observed is discussed.

Anaerobiosis↗