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Biomedical subjects

I M Ledingham

Publications and source records attributed to I M Ledingham.

At least 127 records · Page 7Linked to original sources
PubMed1971

Blood flow characteristics and tissue nutrition in apparently ischaemic feet.

Blood flow in the apparently ischaemic feet of patients with atherosclerotic peripheral vascular disease was only weakly pulsatile but the volume of the resting total foot blood flow was higher than normal. No biochemical evidence of overall regional ischaemia or tissue anoxia was found to explain the aetiology of chronic nutritional skin lesions in these clinically ischaemic feet. The physiological effectiveness of a regional blood flow ultimately depends on its ability to perfuse the tissues, and in this respect it is suggested that pulse and pressure are more important than mere volume. It is further suggested that ischaemic or anoxic nutritional skin lesions develop in the presence of localized tissue perfusion failure and not from any overall regional blood flow insufficiency.

Arteriosclerosis↗
PubMed1970

Foot skin ischaemia in atherosclerotic peripheral vascular disease.

Hyperbaric oxygen and the vasodilating effect of tolazoline hydrochloride were used to investigate atherosclerotic ischaemia of the skin of the foot. Ischaemic feet were divided into two subgroups each with a foot blood flow significantly higher than normal and significantly different from each other. The high blood flow in the ischaemic feet appears to have been an attempt to meet a tissue oxygen need. In some instances this need seems to have been satisfied but without obvious benefit to the ischaemic or anoxic skin. It is suggested that a local rather than a regional blood flow insufficiency is the cause of skin lesions in peripheral vascular disease.

Arteriosclerosis↗