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Biomedical subjects

I M Gupta

Publications and source records attributed to I M Gupta.

At least 37 records · Page 2Linked to original sources
PubMed1977

Malignant melanoma in Nigeria-pathological studies.

Pathological features of twenty-one cases of malignant melanoma studied in the University of Nigeria Teaching Hospital, Enugu during the period January, 1974 to December, 1975 are presented. Malignant melanoma accounted for 2.4% of all tumours and 4.5% of all malignant tumours, greatest age incidence being in the fifth to seventh decades. The male to female sex ratio was 2:1. 73.2% of cases were of the nodular variety. 81% melanomas occurred on the sole of feet validating the hypothesis that the pigmented skin in Africans is resistant to malignant melanoma. Melanoma in Nigerians would appear essentially to be arising from epidermal melanocytes and not from preexisting naevus cells. Hence we do not feel prophylactic removal of plantar moles as suggested by Onuigbo (1975) is desirable. Histologically, there was no clear association between the cell types and the kind of melanoma or invasion of the tumour. The difference in behaviour and natural history of malignant melanoma would appear to have a bearing on the local tissue and also general immune mechanisms of the host.

Adult↗
PubMed1975

D'emblee type of mycosis fungoides of head and neck.

Mycosis fungoides as a disorder of reticulo-endothelial system occurs in the eczematous or psoriatic stage, progresses to infiltrated plaque stage and finally to tumorous form with or without systemic spread. The head and neck is rarely involved. A case is presented in which the disease process started as a tumor (d'emblee type) and remained localized in the head and neck region without a generalized spread. The tumorous lesion rapidly increased in size and involved deeper tissues of the neck to cause infranuclear facial palsy and medial bulging of the tonsil' it also extended in the superior mediastinum casuing pressure on the trachea and the esophagus. The patient died of respiratory failure.

Aged↗
PubMed1975

Indian childhood cirrhosis of the liver: a morphologic evaluation.

Indian childhood cirrhosis of the liver continues to be a major cause of morbidity and mortality of children living in the Indian sub-continent. The present paper deals with the morphological changes in various stages of the disease process. Ballooning and feathery degeneration of hepatocytes, complete absence of fatty change, frequent occurrence of intracytoplasmic hyaline bodies, dissection of pseudolobules by fibrous septa and fibrosis around single cell were notable features. A few cases also showed giant-cell transformation and pseudo-adenomatous arrangement of hepatocytes. The interpretation of morphologic changes has been discussed and the probability of a toxic aetiology has been suggested.

Child↗