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Biomedical subjects

I M Grais

Publications and source records attributed to I M Grais.

7 recordsLinked to original sources
PubMed1990

The long-term treatment of stable angina pectoris with verapamil.

In a double-blind 16-week crossover study, the effectiveness of verapamil therapy for chronic stable angina was evaluated in 19 patients (Phase I). Twelve of these patients were then followed for 38 to 58 months of open-label treatment (Phase II). Clinical responses were assessed with traditional indices, treadmill exercise tests, and a newly developed Performance Index (PI). During Phase I, verapamil resulted in a 50% mean reduction in the number of patients developing effort angina on treadmill exercise, a 15% mean increase in treadmill exercise time, and an 18% mean improvement in the PI. In eight of ten patients, diastolic blood pressure rises during exercise were significantly lowered during verapamil treatment in Phase I. In a limited population of patients followed for long periods of time, our data show that verapamil remains acceptably effective in the treatment of angina pectoris. Though diastolic blood pressure rises were decreased during Phase I, we could not confirm that effect over longer periods of time. Functional capacity as determined by the PI was sustained in Phase II.

Angina Pectoris↗
PubMed1983

Treadmill exercise testing in hypertensive patients treated with hydrochlorothiazide and beta-blocking drugs.

Twelve patients with hypertension who did not become normotensive after treatment with hydrochlorothiazide alone were studied. Treadmill exercise testing was done before and after additional treatment to standing resting normotension with beta-blocker drugs. The double product (peak mean BP times peak heart rate) at peak performance fell significantly because of decreases in systolic arterial BP and heart rate, but diastolic pressures still rose with exercise in ten of the 12 patients, in seven of them to 100 mm Hg or higher. Thus, the data show that patients with hypertension treated to resting normotension with hydrochlorothiazide and a beta-blocker still often demonstrate a significant diastolic BP rise with exercise. In such patients, a rise in diastolic BP with exercise cannot be used as evidence of coronary atherosclerosis. The measurement of the arterial BP response to exercise is probably important in the assessment of the effectiveness of individual antihypertensive regimens.

Adrenergic beta-Antagonists↗
PubMed1977

A case of myocardial abscess evaluated by radionuclide techniques: case report.

A patient with infective endocarditis was evaluated by Ga-67 citrate imaging, Tc-99m pyrophosphate imaging, equilibrium gated blood pool imaging, and Tl-201 imaging of the chest. The diagnosis of ventricular abscess was first suggested by an abnormal gallium scan. At surgery, an abscess was identified in the area where the scan was abnormal, and postoperatively a repeat scan was normal.

Abscess↗