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Biomedical subjects

I M Brook

Publications and source records attributed to I M Brook.

At least 55 records · Page 3Linked to original sources
PubMed1986

Controlling drug release from acrylic polymers: in vitro studies with potential oral inserts.

The use of a drug modified polymer system which can release drugs such as hydrocortisone sodium succinate and chlorhexidine acetate has been explored. By partially coating the drug loaded acrylic, such that it acts as a core with an impermeable membrane covering most of the surface, the rapid releases of the drug can be prevented and near zero-order rates of release achieved. For chlorhexidine acetate the release time was extended from around 20 d to 80 d with at least 60% of the drug being released. A similar potential for the controlled release of hydrocortisone sodium succinate is described and represents an important stage in the development of an intra-oral insert for drug delivery.

Acrylates↗
PubMed1985

Drug release from acrylic polymers via channels and cracks: in vitro studies with hydrocortisone.

Release of hydrocortisone sodium succinate from acrylic resin was found to occur readily on elution in water at 37 degrees C. Increasing the degree of hydration of the acrylic resin by the addition of hydroxyethyl methacrylate impaired rather than enhanced the release of drug. The mechanism for the release of drug is believed to be surface release and drug dissolution into and diffusion via cracks and channels which are formed by incorporation of the drug, producing a 'drug-modified polymer'. Diffusion through the polymer matrix is believed to be insignificant. The results obtained are discussed in relation to this proposed model for drug release. A simple method for the manufacture of the core of an intra-oral insert capable of delivering drugs with MW greater than 400 for systemic and topical oral drug delivery is described.

Acrylic Resins↗
PubMed1983

Chronic granulomatous cheilitis and its relationship to Crohn's disease.

Investigation of a 15-year-old white male patient with chronic granulomatous cheilitis revealed asymptomatic Crohn's disease of the lower gastrointestinal tract. This is reported to support the suggestion that chronic granulomatous cheilitis and Crohn's disease may be intimately related. Tests for nutritional status are shown to be important in the investigation and management of patients with this condition, being the first indication of any gastrointestinal pathology.

Adolescent↗
PubMed1983

Aetiology and incidence of facial fractures in adults.

The incidence, aetiology and trends in fractures of the facial bones occurring in the years 1965, 1970, 1975 and 1980 in the Grampian Region of Scotland are reported. A 2.7 fold increase in incidence occurred during this period. Males are seen to be most at risk and an increase in assault and sports-related trauma is seen. Offshore oil exploration developed during this period and its effects are discussed. Attention is drawn to the differences in the aetiology of right and left malar fractures.

Adult↗
PubMed1980

Angiosarcoma, metastatic to the mandible and maxilla.

A case of metastatic angiosarcoma, which was diagnosed from a biopsy of the presenting oral lesions, is reported and discussed. The case illustrates the aggressive nature of the tumour with its widespread metastasis and its brief course to fatality.

Hemangiosarcoma↗