Biomedical subjects
I M Bogdanova
Publications and source records attributed to I M Bogdanova.
A new approach to the therapy of Duchenne muscular dystrophy with early precursors of myogenesis.
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[Immunologic aspects of cellular therapy].
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[The functional role of fertility alpha2-microglobulin].
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[Transplantation of human fetal tissues--a promising method of treatment of diabetes mellitus].
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[Transplantation of human fetal tissues in hematology].
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[Immunocytotherapy. A novel direction in fetal tissue transplantation].
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[Natural killer activity in diffuse toxic goiter].
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[Effect of the synthetic preparation B 58 on the activity of natural killer and cytostatic cells of the mouse spleen].
The effect of the in vivo treatment with synthetic interferon inducer B-58 on natural killer (NK) and cytostatic cell activity was studied in CBA and A/Sn mice. A marked increase in NK cell activity against target cells YAC-1 was observed in the spleen of CBA mice within 4 days after treatment. On the other hand, NK activity in A/Sn mice was not affected by B-58. However, B-58 was shown to enhance cytostatic cell activity both in CBA and A/Sn mice, when tested against target cells P 815.
[Natural killers and interleukin-2 in mice of the strain MRL/MpJ-lpr/lpr].
The functional activity of natural killers (NK) in the spleen and lymph nodes and interleukin-2 (IL-2) production have been studied in MPL-MpJ-lpr/lpr (H-2k) mice with genetically predetermined autoimmune diseases and CBA (H-2k) mice. In MPL/l mice it has been shown that NK activity in the spleen was markedly depressed already in the first month of life, whereas in lymph nodes there is a substantial NK activity on days 7-10, which reaches its maximum by the second month and by the 6th months is practically intractable. IL-2 production in MPL/l mice was depressed at all stages of investigation.
[The lack of generalized immunosuppression in C57BL/6 mice during progressive growth of syngenic T lymphoma EL-4 and Lewis lung carcinoma 3LL].
The immune competence of C57Bl/6 mice implanted with EL-4 lymphoma of Lewis Lung carcinoma 3LL was investigated during 3 weeks after implantation. Splenic lymphocyte responses to mitogens (Con A, PHA, LPS, PWM) cytotoxic T lymphocytes (CTL) and interleukin-2 (IL-2) production were assessed. A dramatic reduction in mitogenic responses to Con A and PHA was observed during tumour progression. LPS and PWM responses were less depressed. Con A-induced IL-2 production correlated with Con A and PHA responses. Allospecific CTL response to mastocytoma P 815 was not decreased in syngeneic tumour-bearing mice.
[Interleukin-2 restoration of the activity of natural killers during stress].
Interleukin 2 used in vitro and in vivo induces effectively the recovery of cytotoxic activity of natural killers and lectin-dependent cellular cytotoxicity effectors in stress-immobilized CBA mice. This lymphokin can be used for correction of stressor depression in the cells of the natural anti-tumor resistance system.
[Interleukin 2 production in patients with thyroid diseases].
Con A-induced production of interleukin 2 was studied in peripheral blood lymphocytes obtained from 15 normal subjects and 42 patients with different thyroid diseases. It was found that thyroid diseases are accompanied by changes in IL 2 production. The level of IL 2 production by T lymphocytes is determined by the functional status of thyroid glands, their anatomy, stages of the disease and mode of treatment.
[Lectin-inducible cell cytotoxicity and the production of the cytotoxic factor of natural killer cells during immobilization stress in mice].
Mice exposed to immobilization stress manifested a dramatic lowering of the activity of normal killers against YAC-1 tumor as well as against the lectin-induced cellular cytotoxicity mediated by Helix pomatia agglutinin and detected by the cytolytic test against xenogeneic tumor cells K 562. Exposure to stress did not provoke any change in the production of cytotoxic factor of normal killers, whereas dexamethasone (5 X 10(-7) M) in vitro inhibited the production of this factor.
[The natural killer system in the human fetus].
Natural cytotoxic activity of cells from human fetal spleen, liver, bone marrow, appendix, tonsilar glands and thymus was investigated in 14-26-week-old embryos. The spleen and liver expressed powerful NK activity against K-562 target cells from a 22 week-old embryo. Thymocytes and cells from the appendix and tonsilar glands displayed but negligible cytotoxic activity.
[Interleukin-2 and its possible role in the pathogenesis of stress-related changes in the immune system].
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[Mechanism of EA-rosette formation blockade by antisera against cell surface antigens].
The effect of different antisera to cell surface antigens on EA-rosette formation was investigated. Anti-immunoglobulin serum causes almost total blockade of EA-rosette formation by murine spleen and bone marrow cells. Rabbit anti-mouse brain-associated theta-antigen immunoglobulin has the same effect on EA-rosette formation by murine splenocytes but it has a slight action on EA-rosette formation by rat splenocytes. The mixing of rat splenocytes and autologous or mouse thymocytes increased the blocking influence of anti-BA theta-immunoglobulin. These findings indicate a requirement for specific antigen in the test-system for blockade of EA-rosette formation. This antigen is not necessarily expressed on the surface of Fc-receptor-bearing cells.
[Simple method of detection of Fc receptor sites on cells].
A bacterial adhesion technique for identification of Fc-receptor bearing cells is based on the ability of Staphylococcus aureus, Cowan 1 strain, to form rosettes with cells previously treated with immune complexes or heat aggregated Ig G. The new technique is distinguished from other Fc-receptor detection methods by its simplicity and ease of detection of both immune complexes and aggregated IgG-binding cells.