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Biomedical subjects

I M Balkarov

Publications and source records attributed to I M Balkarov.

51 records · Page 3Linked to original sources
PubMed1988

[Morphological characteristics of hyperuricemic variant of chronic latent glomerulonephritis].

The study of a hyperuricemic variant of chronic latent glomerulonephritis in asymptomatic hyperuricemia and gout suggested that relevant pathologic lesion can be morphologically represented by immune-complex glomerulonephritis and reactive mesangial changes as well as secondary tubulointerstitial nephritis. The underlying pathogenetic mechanism in the development of immune-complex glomerulonephritis and secondary tubulointerstitial nephritis is formation of antibodies to antigens of basal glomerular membrane and to alkaline edge of the proximal nephron, respectively. Reactive mesangial changes of the glomeruli reflect mesangiocyte sensitization to the antigens.

Adult↗
PubMed1988

[Disorders of purine metabolism as an etiological factor in renal pathology].

Of 3200 patients admitted to the nephrology department within several years, hyperuricemia was detected in 696. Excluding from this number persons with signs of chronic renal insufficiency (146 persons) and patients who were treated by diuretics (89), the frequency of hyperuricemia was 16.2% which exceeded almost 2-fold (9.2%) the value determined during the examination of 594 healthy persons. The authors discussed a possibility of early development of renal pathology in purine metabolic derangement with hyperuricosuric and hyperuricemic stages characterized by certain clinical peculiarities, including a possibility of development of immune complex nephritis.

Arthritis, Gouty↗
PubMed1986

[Immune complex hyperuricemic nephritis: aspects of its morphology and pathogenesis].

The authors described the results of an immunohistochemical, electron microscopic and morphometric study of the kidney bioptates of 45 patients with latent glomerulonephritis with hyperuricemia, 8 patients with primary gout and 12 patients with latent glomerulonephritis without hyperuricemia. Two possible variants of the involvement of the renal glomerula were revealed against a background of purine metabolism: typical immunocomplex glomerulonephritis and the so called "reactive" mesangial changes. The expression of interstitial changes (by the results of histometric investigation) was maximum in gout, slightly less in latent nephritis with hyperuricemia and minimum in nephritis without hyperuricemia. The authors emphasized the possibility of immunocomplex nephritis as one of the variants of renal lesion in gout and hyperuricemia and the necessity of specifying therapeutic modalities to be used in this condition including general nephrological approaches to the treatment of latent nephropathies.

Biopsy, Needle↗
PubMed1986

[Beta 2-microglobulin in the blood serum and urine of patients with interstitial kidney lesions].

A study of the level of beta 2-microglobulin (beta 2-MG) in the blood serum and urine was conducted in 67 patients: 22 with chronic pyelonephritis, 13 with gout with renal lesion, 25 with chronic glomerulonephritis (5 without hyperuricemia, 20 with hyperuricemia) and 7 with amyloidosis accompanied mainly by renal lesion. A raised level of beta 2-microglobulin was found in the patients with chronic pyelonephritis, gout, latent glomerulonephritis with hyperuricemia, and in over half of the cases its raised level was found in the urine. The results obtained indicate a frequent and in some cases predominant involvement of the tubules as well as interstition in the patients with hyperuricemia.

Adult↗
PubMed1986

[Disordered repair processes in patients with gouty nephropathy].

The reparation activity in lymphocytes using the DNA reparative synthesis test was assessed in 18 patients: 10 suffering from primary gout with renal involvement, 6 suffering from chronic nephritis with hyperuricemia, 1 with hyperuricosuria and 1 with systemic lupus erythematosus. Inhibition of the DNA reparative synthesis was noted in 15 patients (deep in 11 patients and partial in 4). A degree of synthesis inhibition did not depend on renal function and uricemia value. An opportunity of the use of reparation activity as a criterion of the development of disease even at the premorbid stage was discussed.

Adolescent↗
PubMed1985

[Hyperuricemic variant of latent glomerulonephritis].

The authors describe the data of a comparative clinicomorphological analysis made in 40 patients with associated latent nephritis and hyperuricemia and 43 patients suffering from latent nephritis without hyperuricemia. No substantial differences in the disease clinical picture or in the structure of the morphological variants of glomerulonephritis (GN) were found in the above groups of patients. A more detailed morphological study made it possible to reveal a higher incidence of tubulostromal-vascular changes in patients with hyperuricemia. It is assumed that excess uric acid is likely to play an etiological role in the development of latent GN. Emphasis is laid on the necessity of early diagnosis of purine metabolism disorders in patients with latent nephritis whose goal-oriented therapy may improve the characteristics of the uric acid syndrome and renal function.

Adolescent↗
PubMed1975

[Pericarditis and heart tamponade in patients on regular hemodialysis].

Among 137 patients with terminal renal failure maintained on chronic haemodialysis, pericarditis was found in 37. In 11 cases it developed prior to the onset of haemodialysis therapy, and in 26 during various periods within the therapeutic course. In patients maintained on haemodialysis pericarditis is characterized by a protracted course, severe pain syndrome, ability to cause or intensify cardiac failure, to produce cardiac rhythm disorders. In 15 patients pericarditis was complicated by a massive effusion into the pericardiac cavity. In 3 of them the effusion gradually dissolved, 3 other ultimately developed subacute constrictive pericarditis, in the remaining 9 the effusion resulted in tamponade. Two patients died of cardiac tamponade, in the remaining 7 patients 12 transdiaphragmal pericardial punctures were performed. In 2 cases the latter caused severe complications. The discussion deals with the methods of treatment of pericarditis in patients on chronic haemodialysis, with the preventive measures against the effusion, and the means of its management.

Adult↗