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Biomedical subjects

I M Ariel

Publications and source records attributed to I M Ariel.

68 records · Page 4Linked to original sources
PubMedDate not supplied

Tumors of the peripheral nervous system.

Most tumors (benign and malignant) do not arise from the nerves per se, but from the supporting cells; tumors arising from the cells of Schwann are termed schwannoma or neurilemoma--benign or malignant. Surgical extirpation is the only way of treating these tumors. Radiation therapy can offer significant palliation and prolongation of life, but no cures have been observed. Other forms of therapy (chemotherapy, immunotherapy, etc.) have little to offer at this time. Benign tumors can be treated by local surgical extirpation; malignant tumors must be radically resected, including major amputations where indicated. Certain dermatomes have a proclivity to produce tumors, and new growths (benign and malignant) proximal to the one clinically apparent can be expected in certain patients. Neurofibromatosis (von Recklinghausen's disease) is a genetic error of metabolism with a proclivity to produce multiple neurofibrosarcomas, and in about 10 percent of the patients, malignant neurilemomas. Of 100 patients with malignant neurilemomas treated by the author, 74 were considered determinate; among them, the 10-year "cure" rate was 32 percent. Patients with von Recklinghausen's disease had almost as good a 10-year survival rate as those with solitary malignant schwannoma (30 percent vs 39 percent).

Female↗
PubMedDate not supplied

The prognosis of patients who become pregnant after mastectomy for breast cancer.

Forty-seven patients were treated for primary operable carcinoma of the breast and had subsequent pregnancies. Their ages varied from 22-45 years, the median age being 35 years. Each patient with negative nodes received only a radical mastectomy, and each patient who had metastases to the lymph nodes in addition received a course of radiation therapy. None of the patients received chemotherapy. Of the 30 patients who did not have metastases to the lymph nodes, 23 survived a 10-year period (77%). Of the 16 patients who manifested metastases to the lymph nodes, nine survived a 10-year period (56%). No detrimental effect of subsequent pregnancy could be demonstrated even among patients with positive axillary nodes. It is generally agreed that most metastases show up within a 3-year period before incurring a pregnancy. In this series there was no differences between those who delayed. Abortion could not be demonstrated to improve the survival rate; in fact, patients who had abortions did worse than those who did not. We conclude, accordingly, that pregnancy need not be avoided or terminated among those patients who are apparently free of recurrences or residual cancer after undergoing treatment for carcinoma of the breast. The decision to become pregnant and the medical conduct of the pregnant female are best determined by the stage of the cancer and how the malignant potential affects prognosis. Careful consultation should be sought with all support personnel, which should include the husband, spiritual leader, psychologist, etc., to discuss the potential for the patient's surviving and supporting the child.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Carcinoma of the prostate: the treatment of bone metastases by radioactive phosphorus (32P).

The administration of radioactive phosphorus and testosterone benefitted two-thirds of thirty patients with prostate cancer treated. Subjective relief of bone pain occurred in 73% of cases and measurable objective improvement occurred in 50%. Hematopoietic depression occurred in 30% of the patients necessitating readmission to hospital for transfusion. This method of treatment is advocated for patients with widespread osseous metastasis, especially those with severe pain.

Acid Phosphatase↗