Search PubMed⌕ Search

Biomedical subjects

I Luxembourger

Publications and source records attributed to I Luxembourger.

5 recordsLinked to original sources
PubMed1985

Antigonadotropic cell antibodies in the serum of cryptorchid children and infants and of their mothers.

An indirect immunofluorescence test allowed us to study circulating antigonadotropin-cell antibodies in patients with cryptorchidism. Antigonadotropin-cell activity was found in the serum in 14 of 23 cryptorchid boys aged 1 to 11 years and in 12 of 23 infants aged 1 to 3 months; in most of them the antibodies persisted during short-term follow-up. Results of paired study of the mother and infant were concordant in 14 of 15 cases. No such antibodies were found in 24 control male children. These data support the possible role of pituitary autoimmunity in the child and the mother as a factor in testicular maldescent. We found no correlation between the presence or absence of antibodies and the partial luteinizing hormone-Leydig cell deficiency usually found in cryptorchidism.

Adolescent↗
PubMedDate not supplied

[Amineptin dependence. Detection of patients at risk. Report of 8 cases].

The authors relate eight cases of amineptine dependency collected between 1980 and 1988 in 7 women and 1 man treated in the CHU of Besançon (France). The pharmacodependency appeared to be limited mainly to an abuse and a psychic dependence, i.e. a compulsive need to use the drug on a periodic (two cases) or continuing (six cases) basis in order to experience its psychomotor stimulant like effect. The used dosages ranged between 1,000 and 2,500 mg per day. The daily dose was divided into little doses, every hour for example. The induction modality was progressive during weeks or months and a stable dose period was then encountered. In one patient only, we observed a progressive increase of the dose without stabilisation of the dose. The withdrawal of amineptine was obtained without problem except in 2 cases where we observed clinical manifestations of anxiety, psychomotor agitation or bulimia during one day. Four years after the beginning, amineptine dependence was still present in 2 patients. In 4 patients we obtained an interruption of the amineptine pharmacodependency for one to three years. We did not see again the two remaining patients. In two cases, the main diagnosis, according to DSM III, was a major personality disorder (borderline). In the six other cases the diagnosis was a bipolar affective disorder (including four cases with only hypomanic episodes only). In these six patients the main characteristic of their affective illness was the association with other psychiatric disorders, especially personality disorders, such as borderline personality in one case and atypical personality with uncontrolled behavior as the main feature, in the 5 other patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗