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I Lorenz

Publications and source records attributed to I Lorenz.

At least 19 recordsLinked to original sources
PubMed1989

[Modern view of adjuvant chemotherapy in carcinoma of the breast].

The paper presents basic theoretical data on breast cancer chemotherapy and discussed current clinical experience with regard to the introduction of chemotherapy, dosage of applied cytostatics, combination radiotherapy and chemo-hormonotherapy in premenopausal and postmenopausal patients with regional nodes, both positive and negative. This sums up the present tendencies in breast cancer chemotherapy and shows the trends in clinical studies concerned with unsolved problems or contradictory results.

Antineoplastic Agents↗
PubMed1989

[Danol (danazol) in the treatment of fibrocystic breast disease with mastodynia].

The author investigated in a group of 12 premenopausal women with fibrocystic mastopathy with mastodynia, confirmed on mammography, the effectiveness of a synthetic ethisterone derivative--danazole. An objective effect (reduction of the number and/or diminution of nodularities in the mammary parenchyma) was achieved in 67%, disappearance of mastodynia in 100%. As to side-effects only amenorrhoea was observed in 92%, spotting in 8%, an increase of body weight (1-6 kg) in 83% of the treated women. Danol will, with regard to its effectiveness and very good tolerance, if more widely available, substantially extend our therapeutic possibilities in the above indication.

Adult↗
PubMed1988

Generation of mature CD3+ and T cell receptor (TCR) + T cells from a leukemic analogue of the putative human stem cell by T cell conditioned medium containing IL-3, IL-2, and GM-CSF.

Malignant cells of a patient with acute leukemia expressed hematopoietic stem cell antigens such as CD34 and HLA-class II but lacked lineage specific differentiation markers. The leukemic blasts differentiated into mature T cells within 14 days in the presence of a T cell conditioned medium or with a mixture of highly purified interleukin-2 (IL-2) plus recombinant interleukin-3 (IL-3) and recombinant granulocyte/macrophage colony-stimulating factor (GM-CSF). Phenotypically, the maturing cells acquired the T cell-specific differentiation antigens CD2, CD3, and CD8, whereas immature differentiation antigens such as CD34 and Leu19 as well as HLA-class II and the IL-2 receptor CD25 were concomitantly down-regulated within 14 days of in vitro culture. This in vitro maturation involved two to three synchronized cell divisions. Beyond 10 days of culture the leukemic cells produced mRNA specific for the T cell receptor beta and alpha chain, but at no time transcription of T cell receptor gamma chain-specific message was detectable. To our knowledge, these data represent the first in vitro model demonstrating the differentiation of phenotypically mature T cells from immature leukemic cells induced by the combined activities of IL-2 plus IL-3 and GM-CSF.

Antigens, CD19↗
PubMed1987

Metabolic consequences of high protein intake in premature infants appropriate for gestational age.

The metabolic consequences of different levels of protein intake were studied in premature infants appropriate for gestational age (birth weight between 1500 and 2000 g) during the third week of life. The different protein intake was the result of different nutrition, human milk and two formulae containing 1.7 and 2.1 g protein/100 ml, respectively. The increasing protein intake causes an increase in the alpha-amino-nitrogen as well as the urea concentration in the serum, an elevation of total and alpha-amino-nitrogen losses in urine, increased amounts of stool accompanied by increased total nitrogen as well as fat excretion. The results indicate that a protein intake of more than 2.5 g/kg X 24 h creates a metabolic overloading without any advantages. Thus, human milk of mothers delivering preterm is a sufficient nutrition for these infants, also with regard to protein requirements, if feeding volumes of 180 to 200 ml/kg X 24 h are tolerated. Supplementation of human milk or nutrition with high protein formulae can be justified only in infants who cannot tolerate sufficient feeding volumes.

Amines↗
PubMed1986

[Nutrition of very low birth-weight premature infants with enriched breast milk during the adjustment phase].

To enable an enteral nutrition in very low birth weight infants appropriate for gestational age, adapted to the high nutritional requirements, pooled human milk from mothers delivered preterm was enriched with human milk lyophilisate 6 g/100 ml. The concentrations of protein increase from 11.8 +/- 1.2 to 15.8 +/- 2.1 g/l and the non-protein energy substrates raise in the same proportion. Osmolality increases from 291.6 +/- 11.2 to 384.9 +/- 19.6 mosmol/l. The higher protein intake was tolerated without relevant metabolic imbalances. Only small increasing of amino acids concentrations in serum and a higher renal excretion of amino acids could be observed. The nitrogen balance was equalized during the first two days of life and positive from the 3rd day of life. Nitrogen retention was significantly higher in the group fed human milk lyophilisate enriched human milk from the 2nd day of life. Also the postnatal weight losses were significantly lower and the birth weight was reached significantly earlier. Human milk lyophilisate enriched human milk can be recommended for nutrition of very low birth weight infants appropriate for gestational age from the first day of life.

Amino Acids↗
PubMed1986

Influence of protein intake and liver function on acid base balance in premature infants.

In 43 patients with late metabolic acidosis (LMA) the factors promoting LMA were investigated. Postnatal adaptation was distributed in all cases, in 35 patients acidosis developed after introduction of formula feeding. Whereas no differences were observed in renal function (urine volume and renal molar excretion) between acidotic and non-acidotic patients, there was a significantly higher concentration of bile acids in serum (26.1 +/- 9.6 vs 98.6 +/- 21.6 mumol/l), a significantly increased fractional volume of stools (8.2 +/- 1.3 vs 11.4 +/- 1.9% of intake, and higher faecal fat excretion (26.5 +/- 5.2 vs 39.1 +/- 6.6% of faecal weight) in LMA patients than non-acidotic formula-fed infants. It is suggested that impaired postnatal development of liver function caused by severe disturbances of postnatal adaptation (respiratory distress, persistent fetal circulation, sepsis) is one of the most important factors in the pathogenesis of LMA. Thus, liver function should be checked before a protein intake surpassing that of a breastfed infant is introduced. Concentration of the serum bile acid level seems a reliable marker of LMA.

Acidosis↗
PubMed1985

Medroxyprogesterone acetate versus tamoxifen in the therapy of advanced breast cancer.

A comparison of efficacies of medroxyprogesterone acetate (MPA) and the antiestrogen tamoxifen (TX) in the therapy for advanced breast cancer in patients who had already previously been intensely treated showed that, as to the objective remissions, the two drugs can be looked upon as equivalent. Nevertheless, with MPA a better analgetic and anabolic effect--a marked improvement in the performance status (Karnofsky index)--was achieved.

Breast Neoplasms↗
PubMed1985

[Protein metabolism in the small for gestational age newborn in relation to the severity of fetal malnutrition].

The daily nitrogen balance, the amino acid concentrations in serum and urine, and the bile acid concentrations in the serum on the eighth day of life were estimated in newborn infants small for gestational age with different degrees of fetal malnutrition. The amino acid concentrations in urine and serum as well as the total nitrogen losses by urine increase in dependence on the severity of fetal malnutrition. In addition the bile acid concentrations were elevated whereas the urea concentrations in serum remained unchanged. These results point to a deranged liver function which depends on the degree of fetal malnutrition. These special metabolic conditions have to be considered in the nutrition of such infants. The bile acid concentrations seem to be an efficient parameter to estimate this metabolic situation.

Amino Acids↗
PubMed1985

Nutrition of newborns small for gestational age with human milk lyophilisate enriched human milk during the first week of life.

In 24 very low birth weight infants appropriate or small for gestational age, the metabolic response to nutrition with human milk lyophilisate enriched human milk was estimated during the first week of life. In contrast to newborns appropriate for gestational age, in newborns small for gestational age signs of metabolic overloading could be observed: increased urinary amino acid excretion and neonatal cholestasis. Both depended on the degree of fetal growth retardation. It was concluded that nutrition with human milk lyophilisate enriched human milk cannot be recommended for very low birth weight infants during the first week of life. In newborns small for gestational age the metabolic situation has to be estimated before starting a high protein diet. If the level of total bile acids amounts to more than 30 mumol/l, protein intake should be increased carefully during the first week of life.

Amino Acids↗
PubMed1985

Secondary tumors in cancer patients after therapy.

Forty-five thousand three hundred thirteen patients treated in our Institute during the period 1949-1982 were retrospectively analyzed in regard to the appearance of secondary tumors after therapy. Eighty-seven (0.19%) tumors were found, 71 (81.6%) being secondary and 16 (18.4%) simultaneous. Fifty-one (71.8%) tumors were lymphoid, 20 (28.1%) nonlymphoid. Thirty-seven (52.1%) tumors appeared after radiotherapy, 13 (18.3%) after chemotherapy alone. Secondary tumors appeared mostly after 6 years. The prevalence of lymphoid secondary tumors may be explained as a compensatory proliferation of surviving cells progressing to neoplasia. Cytostatics and ionizing radiation as both the initiators and the promoters of malignancy, have besides person's susceptibility a triggering function. From these aspects before any treatment is started all possible carcinogenic factors should be taken into consideration and less carcinogenic procedures with keeping up a full effectiveness should be chosen.

Adolescent↗
PubMed1984

[Development of an independent department and institute for physiologic chemistry at the University of Leipzig].

On the occasion of the 575th anniversary of Leipzig University in the present paper the development of the subject of physiological chemistry up to the foundation of an independent institute of physiological chemistry is explained. The name physiological chemistry first appears in Leipzig by 1850 under C. G. Lehmann who had a private laboratory in his house. A "zoochemical laboratory" in St. Jacob's Hospital was granted to his successor Funke, which was put under the control of the medical clinic after Funke's departure with Huppert as head of the laboratory. In 1865 Carl Ludwig was appointed to a professorship of physiology in the university of Leipzig. By making available proportionate place in the "new physiological institution" and by co-opting qualified assistants Ludwig furthered the subject physiological chemistry with great prevision. The department of physiological chemistry created by him was in turn conducted by Hüfner, Drechsel and Siegfried. On April 1st 1916 the independent institute of physiological chemistry was founded. For the sake of his merits Max Siegfried was appointed its firsts director.

Biochemistry↗