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Biomedical subjects

I Litvan

Publications and source records attributed to I Litvan.

114 records · Page 7Linked to original sources
PubMed1988

Slowed information processing in multiple sclerosis.

Sixteen patients with a definitive diagnosis of multiple sclerosis (MS) and an equal number of matched controls were administered tests of memory and information processing speed. Results indicated a significant long-term verbal memory impairment in patients with MS, with spared short-term memory and memory scanning. Speed of information processing was evaluated with the Paced Auditory Serial Addition Test. The results for the two highest rates of presentation revealed significantly impaired processing in the MS group. Performance at the higher rates and retrieval of information from long-term memory were significantly correlated. These results suggest that slowed information processing is a deficit that contributes to long-term memory impairment in patients with MS.

Adult↗
PubMed1988

Multiple memory deficits in patients with multiple sclerosis. Exploring the working memory system.

Some patients with multiple sclerosis (MS) demonstrate impaired memory. A group of 16 patients with MS who were mildly to moderately affected (Kurtzke Expanded Disability Status Scale Score = 3.8) were studied, and they were compared with a matched control group on tests of "working memory." The working memory system was explored by evaluating the amount of information that can temporarily be held in a buffer system during encoding. Results indicated that patients with MS have difficulty in processing information at the level of a hypothesized articulatory loop in working memory. This deficit was correlated with their retrieval of verbal information from long-term memory, as well as how accurately they processed verbal information presented at a rapid rate. There was no significant relationship between ratings of MS severity or number of plaques visualized on magnetic resonance imaging scans and the degree of working memory deficit.

Adult↗
PubMed1986

Does reversed laterality really exist in dextrals? A case study.

We report a case of a right-handed patient who, after a massive left-hemisphere infarction, had neuropsychological disturbances compatible with a right-hemisphere lesion. This has been previously called 'reversed laterality'. Two new aspects of this pattern are described: the right hemisphere is as capable as the left in processing complex syntactic and higher psycholinguistic stimuli; reversed laterality is not complete, ideomotor praxis is the only function that does not follow an inverted representation. The existence of different forms of cerebral organization in dextrals is discussed.

Agraphia↗
PubMedDate not supplied

[Recent advances in Parkinson disease].

OBJECTIVE: To evaluate the latest advances in the diagnosis and symptomatic pharmacological treatment of patients with Parkinson's disease at different stages. DEVELOPMENT: In this article we summarize the criteria for clinical diagnosis of Parkinson's disease based on recent clinico-pathological studies. We evaluate the different therapeutic options at early and late stages of the illness in view of the results of recent, controlled, double-blind studies in which the efficacy of new dopaminergic agonists (carbergolin, pramipexol and ropinirol) and catechol-O-methyl-transferase enzyme inhibitors (COMT; entacapone and tolcapone) are compared with placebo and with established treatments (e.g. levodopa and bromocryptin). CONCLUSIONS: Levodopa is still the most important advance yet made in the treatment of Parkinson's disease, but new dopaminergic agonists and COMT inhibitors are useful additions to the possibilities available for the treatment of early and late stages of the illness and may be included in modern guidelines for treatment.

Antiparkinson Agents↗