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Biomedical subjects

I Lindgren

Publications and source records attributed to I Lindgren.

At least 37 records · Page 2Linked to original sources
PubMed1980

Effect of mucolytic pretreatment on gastric mucosal coating with barium sulfate in the rat. A scanning electron microscopic investigation.

Freshly prepared isolated rat stomachs were used to examine the adherence of barium sulfate particles to the mucosal surface by scanning electron microscopy. The stomachs were pretreated with sodium bicarbonate alone or in connection with N-acetyl-L-cysteine and then treated with barium sulfate specially designed for double contrast examination of the stomach. The best adhesion of the contrast medium was obtained when the mucosa was pretreated with both the alkaline and mucolytic agent indicating that, for the optimum adherence of the contrast medium, the mucosal surface must be as clean as possible.

Acetylcysteine↗
PubMed1980

Morphological and histochemical changes in the mucosa of the continent ileostomy reservoir 6--10 years after its construction.

Morphological and histochemical changes in the mucosa of the continent ileostomy reservoir were studied in 13 patients who had been provided with a continent ileostomy reservoir 6--10 years before the investigation. Biopsy specimens were taken for evaluation of basal morphology, morphometry, and enzyme histochemical analyses. The villi were predominantly finger-like, but the villus height was reduced compared with normal. The crypt layer and the number of cells in each crypt were increased. The number of mitoses was normal or slightly subnormal. In comparison with biopsies taken 1 year after construction of the reservoir, there was an increase in villus height and mucosal volume and a decrease in the number of mitoses, whereas the number of cells per crypt was unchanged. The surface to volume ratio decreased progressively during the 6- to 10-year period. This decrease was partly caused by an increase of the mucosal volume. The epithelial cell layer was intact, and no changes were seen in the microvillus layer. No alarming changes in terms of dysplasia, fibrosis, or progressive atrophy were found. Histochemical investigation showed a high enzymatic activity in the epithelial cells as concerns both the oxidative metabolism and the secretory function.

Acid Phosphatase↗
PubMed1979

The protective effect of BCG vaccination as indicated by autopsy studies.

In a detailed study of the pathology of tuberculous infection made in Finland in 1961, tuberculous foci were found at autopsy in 61 of 67 non-vaccinated subjects and in 35 of 83 BCG-vaccinated subjects, all of whom had died between the ages of 1 and 45 years (with 2 exceptions from causes other than tuberculosis). In the present note on the same material, national information on tuberculin sensitivity and tuberculosis mortality has been used to calculate the risk of tuberculous infection in Finland at different times and ages during the lifetime of these subjects. From these risks of infection in Finland it was estimated that 63 or 64 of the non-vaccinated subjects had been infected during their lifetime and that between 25 and 31 of the BCG-vaccinated subjects were expected to have been naturally infected (had they not been vaccinated) between the time of vaccination and death. It is concluded that virtually all tuberculous infections in unvaccinated subjects lead to pulmonary foci, which are demonstrable at autopsy. Further, the same appears to be so in vaccinated subjects; there is no evidence to support the suggestion that in man BCG vaccine can prevent the establishment of infection in an exposed subject. The effects of BCG (as demonstrated in the earlier paper) appear to be confined to limiting the multiplication and dissemination of the bacilli and the development of lesions following infection.

Adolescent↗
PubMed1979

Accuracy of 100 mm x 100 mm mirror optic camera technique as compared to normal chest radiography technique.

Full size and 100 mm x 100 mm mirror optic camera (photofluorographic) chest films of 121 patients were read by a team of four radiologists. Altogether 2781 diagnostic statements were reported, 968 of which were of primary importance, and only these statements were analysed. Error rates with the standard technique varied between 16 and 31% and with the 100 mm x 100 mm technique between 21 and 38%. The difference in error rates between the techniques used was not statistically significant but there were significant differences between the individual radiologists.

Clinical Competence↗
PubMed1978

Scanning electron microscopy of the spreading of barium sulfate suspensions on the gastric mucosa of the rat. Effect of wetting agents, bile salt and lecithine.

Scanning electron microscopy was performed on the rat stomach mucosa after application of BaSO4 and three barium-containing commercial contrast media. The degree of flocculation was assessed; flocculation could be prevented by using synthetic wetting agents and by physiologic, natural emulsifiers, sodium taurocholate and lecithine.

Animals↗
PubMed1978

Lecithine as an adjuvant in resorption of contrast medium in oral cholecystography.

No or poor filling of the gallbladder was obtained in 21 patients at cholecystography. They were re-examined after 10 days of later with the addition of lecithine to the contrast medium. The filling of the gallbladder, which was without abnormality, was improved in all cases. The mechanism of this effect is discussed.

Adjuvants, Pharmaceutic↗