Search PubMed⌕ Search

Biomedical subjects

I Leden

Publications and source records attributed to I Leden.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Can the chronically ill become the chronically healthy?].

Sick leave from work is on the increase throughout the Western world, despite improvements in welfare and the continual mechanization of heavy industry. By means of early, active rehabilitation measures in cases of musculoskeletal disorders, the duration of sick certification can be reduced and extended absence from work prevented. This has been demonstrated in a successful cooperative project involving the health and social services where, after two years in operation, the saving in costs to the community is calculated to have been SEK 4.5 millions. A brief outline of the project is given in the article.

Absenteeism↗
PubMed1988

Aspects of the history of rheumatoid arthritis in the light of recent osteo-archaeological finds.

Rheumatoid arthritis (RA) is one of our most common disabling diseases today. Whether or not RA also existed in ancient times has been questioned and debated in recent years. Supporters of the view of recent onset claim that evidence of the existence of RA in antiquity can be found neither in old literature nor in paintings--and most important--convincing paleopathological finds are lacking. The following presentation reviews the results of an examination of skeletons found during an excavation of a neolithic burial place in the island of Gotland, Sweden. In two skeletons there were marked peripheral changes in both large and small joints. These changes are compatible with in vivo presence of a chronic aseptic polyarthritis. Different diagnostic possibilities for such polyarticular joint disease are discussed. It is suggested that RA might be the most probable alternative although other possibilities cannot be excluded.

Adult↗
PubMed1985

Flexor tenosynovitis (FTS): a risk indicator of abnormal glucose tolerance.

Diabetes mellitus (DM), particularly of long duration and insulin dependent, can be accompanied by a variety of locomotor system disorders. However, musculo-skeletal syndromes can also appear in patients with mild glucose homeostasis disturbances. Sometimes these locomotor complaints may precede the diagnosis of the deranged glucose metabolism and hence give a clue to the underlying glucose homeostasis abnormality. In the present work, glucose metabolism was studied in 39 patients presenting with palmar flexor tenosynovitis (FTS) but without any other rheumatic manifestations. For comparison, glucose homeostasis was also studied in 44 patients with FTS accompanying rheumatoid arthritis (RA). In the first group, 23% had an abnormal oral glucose tolerance test (OGTT), a significantly increased frequency vis-à-vis the 4.5% found in the RA group and vis-à-vis the 5.4% reported for the general population. It is concluded that in the absence of any other rheumatic disease, FTS is a risk indicator of disturbed glucose metabolism and that a simple screening procedure for the purpose of disclosing glucose homeostasis abnormalities is warranted in patients presenting with FTS.

Adult↗
PubMed1984

Glucose metabolism in patients with rheumatoid arthritis.

Several studies made during the first half of this century suggested an association between chronic arthritis and disturbed glucose metabolism. Moreover, increased prevalence of IGT in patients with idiopathic FTS of the palms has recently been reported and RA is a disease commonly accompanied by FTS. Furthermore, patients with RA are often exposed to drugs that may precipitate or uncover mild undiagnosed DM. For these reasons, glucose tolerance was studied in 101 patients with classical or definite RA. Of these, 4 (4%) had an established type II DM and 6 (6%) a previously undiagnosed IGT. The observed frequencies of disturbed glucose metabolism in RA did not differ from the prevalence rates reported for the general population in Sweden. Hence, this study does not support the previous reports claiming an association between chronic arthritis and disturbed glucose metabolism.

Adult↗
PubMed1983

Nerve palsy after knee arthroplasty in patients with rheumatoid arthritis.

Forty-two consecutive knee arthroplasties on rheumatoid knees (19 Attenborough, 20 Total Condylar, 3 Marmor) were examined pre- and postoperatively for signs of below-the-knee nerve lesions. Sixteen of these knees were also studied neurophysiologically (EMG). Four patients (knees) had peroneal nerve palsy, three early and one late. Three further knees had only EMG signs of nerve lesion. Predisposing factor was correction of flexion contracture of more than 10 degrees and especially when combined with varus change in alignment. Preoperative EMG could not predict nerve lesion.

Action Potentials↗
PubMed1983

Locomotor system disorders in diabetes mellitus. Increased prevalence of palmar flexortenosynovitis.

Diabetes mellitus (DM) may be accompanied by a variety of locomotor system disorders including several hand syndromes. It has been suggested that palmar flexortenosynovitis (FTS) might be included among these hand syndromes, but no conclusive data have been available. Furthermore, recent studies have indicated that FTS may be a clue to previously undiagnosed impaired glucose tolerance. In the present study the prevalence of FTS among diabetics without inflammatory rheumatic disease was 11% compared with less than 1% (p less than 0.001) in a reference group. Thus, FTS could be included among the locomotor system disorders which are associated with DM.

Adult↗
PubMed1983

Autonomic nerve function in rheumatoid arthritis of varying severity.

Autonomic nerve function was evaluated by deep breathing and tilt table tests in 17 patients with rheumatoid arthritis (RA) and in 24 healthy control subjects. The results showed that all RA patients had increased heart rates at rest, irrespective of the severity of the disease. Patients with severe RA had increased systolic and diastolic blood pressures before and after tilting. Pronounced abnormalities in the immediate heart rate reaction to tilting indicating autonomic neuropathy (AN) were also demonstrated in patients with severe RA. The abnormal immediate reaction to tilting was mainly the result of vagal neuropathy. From the present study it is evident that severe RA may be accompanied by AN and the consequences need to be elucidated.

Adult↗
PubMed1981

Varying distribution of acetylation phenotypes in RA patients with and without Sjögren's syndrome.

The acetylator phenotype status was studied in 61 patients with rheumatoid arthritis (RA), of whom 27 had associated Sjögren's syndrome (SS). The acetylation tests were carried out by means of isoniazid and in 24 patients also with the use of dapsone; there was complete agreement between the outcome of the two tests. The results showed that the frequency of slow acetylators in the whole material was 59%. In RA patients with SS, however, the frequency of slow acetylators was as great as 78%, while it was only 44% among patients without SS (p less than 0.02). Thus, there appears to exist a (pharmaco) genetic difference between RA patients with and without SS. In addition, toxicodermias were found to be more frequent in RA patients with than without SS (P less than 0.01). However, this could not be systematically correlated to slow acetylation.

Acetylation↗