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Biomedical subjects

I Lambert

Publications and source records attributed to I Lambert.

53 records · Page 3Linked to original sources
PubMed1975

[Investigation on protein and protein fractions concentration in the serum of healthy children over one year old (author's transl)].

Protein concentration and the relative percentage of protein fractions in serum have been studied in 2 to 15 years old 226 healthy children. The mean values and standard deviation were calculated for every year of child life. The correlation analysis of all parameters investigated with the age of the children was also presented, as well as the relationships between the various parameters.

Adolescent↗
PubMed1975

[Study of the antigenic properties of the duodenum juice in children with cystic fibrosis (author's transl)].

Comparative study of the antigenic properties of the duodenal juice has been carried out; the samples of duodenal juice were collected from the following three groups of children: 1) healthy children 2) children with lambliosis 3) children with cystic fibrosis. The method of double diffusion and precipitation in agar according to Ouchterlony and immunoelectrophoresis technique according to Scheidegger were used. The author's own specific rabbit antisera were applied. On the basis of the results achieved the conclusion may be drawn that the duodenum content of children suffering from cystic fibrosis includes, apart from antigens immunologically identical with the duodenal content of healthy children, also a separate antigen with specific traits for cystic fibrosis. It was also found that a pathological mucoprotein, appearing sporadically in the duodenum juice of children with lambliosis is in no connection with the antigen specific for cystic fibrosis.

Age Factors↗
PubMed1975

[A direct micromethod for transferrin level determination in human serum (author's transl)].

All the methods of quantitative estimation of transferrin concentration applied until recently have consisted in calculating the amount of this protein through the amount of iron bound in the blood serum. For this purpose the total iron binding capacity of serum (TIBC) has to be determined and then transferrin concentration is calculated. The calculation is based on the fact found by Ehrenberg and Laurell (1955) that two atoms of trivalent iron are selectively bound with one molecule of transferrin. The disadvantage of this method consists mainly in the necessity to carry out the measurement twice in every serum sample and in the large amount of material necessary for the analyses: this is a great inconvenience for pediatric clinics. The single-radial diffusion method in agar-gel was evaluated to be very advantageous for quantitative estimation of transferrin because of its simple technique and reaction specifity. The quantitative estimation is possible by the pilot calibration curve that represents the relationship of the diameter of a given circle and transferrin concentration. The quantity of material necessary for analysis amounts to not more than 5 mul of serum. Specific antitransferrin serum has to be imported and this seems to be the only reason why the said technique has not been used in Poland so far. The sera and vaccine laboratories in Warsaw have recently started to produce this antiserum and pure human transferrin. This has stimulated us to work out the single-radial diffusion method in agar based on Polish antiserum and Polish standard. The quality of the Polish specific rabbit antitransferrin serum and Polish pure human transferrin was tested by the immunoelectrophoretic method. The above findings provide the evidence that the Polish reagents are as good as those of the Behringwerke. Single-radial diffusion in agar gel should be carried out under the following conditions. 1) reaction temperature: 20-22degreesC 2) reaction time 24 hours 3) optimum concentration of antitransferrin serum in agar is 1:5.2. The error of the immunochemical method was determined experimentally and was found to be 9.05%. The results obtained with Polish and Behringwerke reagents were compared and were very similar.

Animals↗
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Plastic ware.

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Amino Acids↗
PubMedDate not supplied

Neonatal abstinence syndrome.

A 12 month review of infants admitted with neonatal abstinence syndrome to a neonatal intensive care unit was undertaken. The relationship of maternal drug abuse to symptoms, the effectiveness of pharmacologic agents in controlling symptoms and the length of inpatient stay were investigated. A retrospective review of maternal and infant records was performed. Those infants with a serial Finnegan score greater than 8 were treated. Pharmacologic treatment was oral morphine sulphate (0.2 mg 4-6 hourly), phenobarbitone (3-7 mgs/kg/day), or combination of the above. 43 infants were admitted to the hospital during the year. The average maternal age was 24.6 years, (18-34 years). Drug use volunteered by the mothers was methadone alone in 6 cases, methadone and benzodiazepines in 14, methadone and heroin and benzodiazepines in 7, methadone and heroin in 10, heroin alone in 2, and other multiple drug use including oral morphine sulphate, dothiepin and cannabis in 4. Average gestational age was 40.3 (35-42 weeks). The average birthweight was 2.81 kgs (1.89-3.91 kgs). Time to onset of withdrawal symptoms was 2.8 (1-13) days. The duration of pharmacologic treatment (oral morphine sulphate and/or phenobarbitone) was 21.8 (1-62) days. The total hospital stay for the 43 infants was 1,011 days. This study confirms that polydrug abuse is the commonest type of drug abuse in Dublin. The duration of withdrawal symptoms is loosely related to drug type, but increasing duration of symptoms is noted for infants exposed to benzodiazepines. Our experience would favour the use of morphine sulphate to treat pure opiate withdrawal symptoms. Over the 12-month period, there was an average occupancy of 3 beds per day in the paediatric department.

Adolescent↗