Biomedical subjects
Publications and source records attributed to I L Tarvid.
Hydrocortisone was shown to prompt the accumulation of pancreatic enzymes taking part in the processing of food protein components in food-deprived chicks. The quality of the enzymes synthetized under hormonal induction does not differ from that in control groups.
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Preparations of chicken small intestine were used in the experiment in vitro simulating processes of membranous digestion (inverted intestinal segments) and absorption (inverted intestinal myasis). It was established that lysozyme was hydrolyzed on the internal mucosa surface regardless of its concentration in the gastro-intestinal tract, and only insignificant quantity of lysozyme (0.027%) penetrates the intestinal wall. The method of lysozyme determination through its action on the cellular wall of Micrococcus lisodeicticus, and highly efficient liquid chromatography were used to study the transport process. The data presented have evidenced that lysozyme is well hydrolyzed under the action of intestinal peptide hydrolyses, and only insignificant amounts of non-splitted lysozyme can penetrate the blood.
Studies have been made of changes in catalytic activity and regulatory properties of membrane and intracellular glycyl-valine dipeptidase from the small intestine of chicks ageing from 1 to 40 days. Gradual decrease in the activity of membrane glycyl-valine dipeptidase was found during postnatal life together with formation of proximodistal gradient in the distribution along the intestine with maximal activity in the distal part. The magnitude and direction of regulatory effects of modificators (tributyrine, sucrose, L-methionine) depend on the age of chicks. Intracellular enzyme does not undergo any significant changes in its regulatory properties and in the level of its activity along the intestine during postnatal development of chicks.