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Biomedical subjects

I L Swann

Publications and source records attributed to I L Swann.

9 recordsLinked to original sources

Vitamin D deficiency: prevention or treatment?

BACKGROUND: Vitamin D deficiency is a chronic condition which contributes to general ill health and seems to be re-emerging in our catchment area since funding of vitamin D supplementation by Primary Care Trusts ceased. This study aims to verify this situation and to assess the cost effectiveness of reintroducing vitamin D supplementation in the Burnley Health Care NHS Trust. METHODS: Vitamin D deficient patients presenting between January 1994 and May 2005 were identified and data retrospectively collected from their case notes. The cost of treatment and the theoretical cost of primary prevention for the Trust population were calculated using previous and current DoH guidelines. RESULTS: Fourteen patients were identified, of whom 86% presented in the last 5 years and 93% were of Asian origin. The incidence of vitamin D deficiency for our population is 1 in 923 children overall and 1 in 117 in children of Asian origin. The average cost of treatment for each such child is pound2500, while the theoretical cost of prevention of vitamin D deficiency in the Asian population through primary prevention according to COMA guidance is pound2400 per case. CONCLUSIONS: Vitamin D deficiency is re-emerging in our Trust. The overwhelming majority of our patients are of Asian origin. The cost of primary prevention for this high risk population compares favourably both medically and financially with treatment of established disease. We suggest that Primary Care Trusts provide funds for vitamin D supplementation of Asian children for at least the first 2 years of life.

Child, Preschool↗

Severe iron deficiency anaemia and stroke.

Neurological complications of severe anaemia in childhood are rare. We report a case of severe iron deficiency in a child of 23 months, presenting as an acute hemiparesis.

Anemia, Iron-Deficiency↗

Anaemia, vitamin E deficiency and failure to thrive in an infant.

An 8-week-old boy presented with failure to thrive from birth. He had been fed with breast and formula milk. He had an anaemia of 6.6 g/dl with polychromasia, nucleated red blood cells and immature myeloid cells in the peripheral blood. He showed evidence of haemolysis with a reticulocyte count of 120 x 10(9)/l, a raised unconjugated bilirubin and had low plasma protein levels. Investigation revealed a low vitamin E level and a diagnosis of cystic fibrosis.

Anemia↗

Childhood croup.

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Acute Disease↗

Teething complications, a persisting misconception.

Fifty children were admitted to hospital with symptoms of illness that were attributed, by the parent or general practitioner, to the process of teething in the course of one year. In all but 2 cases an organic cause, other than teething, could be found and the most serious conditions were meningitis in one patient and febrile convulsion in 11.

Child, Preschool↗

Influence of simultaneous low amniotomy and oxytocin infusion and other maternal factors on neonatal jaundice: a prospective study.

In a prospective study of 196 consecutive single births a significant increase in serum bilirubin concentrations was found in infants born after low amniotomy induction and oxytocin infusion compared with those born spontaneously. This relationship was not dose-dependent and may have been associated with artificial interruption of pregnancy rather than the oxytocin itself. Infants delivered after spontaneous labour accelerated by oxytocin showed no such increase. The hormonal surge at the spontaneous onset of labour may affect fetal enzyme induction, but other factors, such as methods of infant feeding and oral contraceptive use, were found not to be significant.

Bilirubin↗