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Biomedical subjects

I L Martin

Publications and source records attributed to I L Martin.

At least 73 records · Page 4Linked to original sources
PubMed1981

Interactions of beta-carbolines with the benzodiazepine receptor: structure-activity relationships.

The effects of a number of beta-carboline derivatives on [3H]flunitrazepam binding to the benzodiazepine binding site were investigated. The potency of beta-carbolines at the benzodiazepine binding site appeared to be determined largely by the aromaticity of the molecule. Norharmane-3-carboxylic acid ethyl ester was considerably more potent (IC50 10 nM) than its tetrahydro-beta-carboline analogue (IC50 6 microM). There is essentially no difference in potency between the (+)- and (--)-forms of the tetrahydro-beta-carboline-3-carboxylate analogues.

Animals↗
PubMed1980

Determination of 5-hydroxytryptamine in rat brain regions by gas-liquid chromatography with electron-capture detection.

An assay method for measurement of 5-hydroxytryptamine in rat brain areas is described. The procedure involves extraction with a liquid ion exchanger followed by acetylation and reaction with pentafluoropropionic anhydride. The resultant beta-carboline is separated and quantitated using gas-liquid chromatography with electron-capture detection. The procedure also works well with 5-methoxytryptamine standards, and the tissue samples were checked simultaneously for the presence of this amine. The results indicate that concentrations of 5-methoxytryptamine in all areas studied (brain stem, hypothalamus, frontal cortex, and striatum) are less than 10 ng/g.

5-Methoxytryptamine↗
PubMed1978

Bulbospinal tryptaminergic neurones. A search for the role of bulbospinal tryptaminergic neurones in the control of sympathetic activity.

1. The possible role of bulbospinal tryptaminergic neurones in the control of sympathetic activity has been investigated in anaesthetised cats. 2. Depletion of spinal cord stores of 5-hydroxytryptamine was achieved by systemic administration of p-chlorophenylalanine or by intraspinal microinjections of 5,6-dihydroxytryptamine. 3. Blood pressure was little changed by these treatments, neither was the pattern of ongoing activity in sympathetic nerves (arterial pulse rhythmicity and respiratory modulation), the influence of pulmonary afferent nerves on this activity (determined by an airway occlusion technique), the sympatho-inhibitory influence of the carotid sinus baroreceptors, nor the sympatho-inhibitory or -excitatory influences of somatic afferent nerves. 4. Since both p-chlorophenylalanine and 5,6-dihydroxytryptamine treatment caused extensive disruption of the bulbospinal tryptaminergic neurones, it was concluded that these play no significant role in the mediation of the responses tested in anaesthetised cats in the present study.

5,6-Dihydroxytryptamine↗