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Biomedical subjects

I Krc

Publications and source records attributed to I Krc.

At least 73 records · Page 4Linked to original sources
PubMed1982

Malignant lymphomas primarily involving the gastrointestinal tract.

Primary gastrointestinal lymphoma (PGIL) develops mostly on the basis of lymphoplasmocellular infiltration following an alteration of gastric or intestinal mucosa; its evolution is enhanced by a simultaneous defect of cell-mediated immunity. The paper deals with clinical, biochemical and immunological findings observed in 22 patients with PGIL during a course of 10 years. Some illustrative patient summaries are reported in a more detailed description. In histological terms, the cases were classified according to the Kiel classification. There seems to be an unfavourable prognosis of the disease, the average survival being about 10 months and cytostatic treatment is not tolerated well. The particular features of PGIL important for the diagnosis and treatment are pointed out.

Adolescent↗
PubMed1982

Increased serum beta-2-microglobulin level in patients with inflammatory bowel disease.

Beta-2-microglobulin (B2m) serum levels were measured by newly developed electroimmunoassay in a group of patients with inflammatory bowel disease. Increased serum B2m concentrations were found in 66.7% out of 93 subjects with Crohn's disease and in 56.0% out of 25 subjects with idiopathic proctocolitis. According to the author's view, serum B2m can be regarded as a useful adjunct to other immunological markers in diagnostic evaluation and monitoring of Crohn's disease. The high B2m level may reflect elevated biosynthesis and release from immunologically activated lymphocytes in areas of inflammation.

Adult↗
PubMed1980

[Richter's syndrome].

A report is presented on a case of Richter's syndrome in a 77-year old female patient. The pathological process stretched over two year starting as chronic lymphatic leukemia with typical features of the clinical and hematological pictures. No cytostatics were used. In the terminal stages, the cytological picture had changed to the exten that a clinical diagnosis of Richter's syndrome could be established. Histological tests of the necroptic material revealed the presence in lymph nodes of structures of lymphogranuloma with Reed-Sternberg's cells. Monoclonal gammapathy IgM was another noteworthy feature.

Aged↗
PubMed1980

Crohn's disease, serum immunodepressive factors and circulating immune complexes.

The presence of serum immunodepressive factors (SIDF), able to inhibit E-rosette formation of normal donor lymphocytes and the presence of circulating immune complexes (CIC) was studied in sera from 45 patients with Crohn's disease. Significantly elevated levels of both SIDF and CIC were detected in the majority of the examined cases. The parameters seem to correlate well with the disease activity. The effect of SIDF on E-rosette formation could be at least partially neutralized by simultaneous incubation with levamisole.

Antigen-Antibody Complex↗