Biomedical subjects
Publications and source records attributed to I Korom.
We describe a 35-year-old man with cutaneous, mucosal, pulmonary, and bone involvement of xanthoma disseminatum. The 7-year course of the disease and the results of light and electron microscopic and immunocytochemical examinations are presented.
With paraneoplastic skin diseases, we distinguish between obligatory and facultative symptoms. These may be caused by the tumor via allergic or immunologic mechanisms, but mostly the mechanism is unclear (e.g. coincidental). After removal of the tumor, the signs and symptoms should disappear. It is important to avoid strong immunosuppressive treatment, because it may produce dissemination of the tumor.
A 24-year-old female developed a painless swelling adjacent to the left ear. This was shown to be eosinophilic angiolymphoid hyperplasia (ALH). Three months later she developed a nephrotic syndrome. Renal biopsy revealed membranous nephropathy. This is the first non-Japanese case of dermal eosinophilic ALH and nephrotic syndrome; steroid treatment followed by surgical removal of the tumour resulted in complete remission in the renal lesion.
We give a retrospective survey on the clinical, histological, biochemical, and pathogenetical aspects of sclerodermiform changes rarely accompanying porphyria cutanea tarda (PCT). Sclerodermiform changes were seen in 12 patients (2% of all our PCT cases). In these patients, no correlation was found between the severity of the dermatological signs and symptoms and the degree of disturbance in the porphyrin metabolism. Biochemical remission was not accompanied by improvement of the sclerodermiform changes. The proportion of porphyrins with 4 or 5 COOH-groups was higher than that of PCT patients without sclerosis. The findings are consistent with the view that the development of sclerodermiform changes cannot be merely explained by phototoxic reactions, but the "dark-effect" of the porphyrins may also play an important role in the pathogenesis.
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Case report about a 79 year old man with transient acantholytic dermatosis (TAD). Review of the literature of Grover's disease.
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The population in an arsenic polluted area of Hungary was studied in respect of dermatological signs. Melanosis was observed in 23,75 per cent and keratosis in 10,83 per cent. Vitiligo has been present in 3 per cent of the population being partly associated to melanosis and partly independent. The observations suggest that arsenic does not only induce malignant neoplasms but also enhances development of benign skin tumours.
Characteristic skin and mucous membrane lesions of hyalinosis and consequent calcifications in the brain have been demonstrated in a female patient. Histology and electronmicroscopy revealed also characteristic features of the rare disease.
The authors describe a case in which a type IV and type II/b hyperlipoproteinemia (HLP) occurred in combination within one family. The father had Fredrickson IV type HLP, the mother type Fredrickson II/b HLP, and the child (an 11 months old male infant) Fredrickson IV type HLP. The infant with HLP IV showed signs of juvenile xanthogranuloma without lipoid storage. The combination of types IV and II/b within one family is a rarity, and it is interesting that the Fredrickson type IV HLP was associated with juvenile xanthogranuloma without lipoid storage. The literature so far contains no data on the joint occurrence of the two latter conditions.
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