Search PubMed⌕ Search

Biomedical subjects

I Kitano

Publications and source records attributed to I Kitano.

At least 37 records · Page 2Linked to original sources
PubMed1994

Failure of forskolin to elevate the endocochlear potential in kanamycin-poisoned animals.

The effect of forskolin (FSK) on the endocochlear potential (EP), K+ activity (AK), Na+ activity (ANa) and Cl- activity (ACl) in scala media (SM) was compared between normal and kanamycin (KM)-poisoned guinea pigs by means of double-barrelled ion-selective microelectrodes. The perfusion of the scala vestibuli (SV) with FSK (200 microM) produced EP elevation in normal animals whereas FSK failed to do it in KM-poisoned animals. FSK increased ACl of SM with no significant change in AK and ANa of SM in both groups of animals. Histological examination of KM-poisoned animals showed damaged outer and inner hair cells with an intact appearance of the stria vascularis. The mechanism underlying the failure of FSK to elevate the EP in KM-poisoned animals is discussed.

Animals↗
PubMed1994

[Upper cervical discitis: case report].

A 48-year-old man complained of severe neck pain. T1-weighted magnetic resonance imaging (MRI) after intravenous injection of Gadolinium disclosed homogeneously enhanced masses in the retropharyngeal soft tissue, in the inter-vertebral disc space between C3 and C4, and in the spinal epidural space behind the vertebral body. The symptoms of the patient improved smoothly after intravenous injection of antibiotics without surgical procedure. In this case, MRI was very important and useful in the prompt diagnosis of the disease.

Anti-Bacterial Agents↗
PubMed1994

[The role of speech therapists on speech language disordered children].

As psychological and physiological development and circumstances vary considerably, the problems of speech and language in children are further complicated. The speech therapists (ST) who have been concerned with these children and their families are requested eagerly to reconsider and control their own communicative attitude. Furthermore, STs have to improve clinical technique that is appropriate to each child. In this report, the author shows the outline of the speech and language problems of children, and discusses the merit and demerit of speech therapy itself. The clinical approach for motor speech disturbance and sensory language disorder is also described.

Child↗
PubMed1994

[Mixed angioma of the brain: report of two cases].

Clinical features of two patients with mixed angiomas are presented. One patient with a cerebral venous angioma with arterial components was successfully treated with radiation therapy; and the other, who had a common draining vein with cerebellar arteriovenous malformation and venous angioma, was treated with surgical removal of the arteriovenous malformation. These two cases suggested that there is a similarity between the pathogenesis of arteriovenous malformation and venous angioma in the brain.

Adult↗
PubMed1993

Involvement of Cl- transport in forskolin-induced elevation of endocochlear potential.

To determine the possible involvement of Cl- transport in the forskolin-induced endocochlear potential (EP) elevation, the effect of forskolin on the EP was examined in Cl(-)-free artificial perilymph (aPL) as well as in the presence of Cl- channel blockers. The perfusion of scala vestibuli (SV) with forskolin (200 microM) dissolved in Cl(-)-free aPL failed to produce an EP elevation, while SV perfusion of forskolin dissolved in normal aPL elevated the EP. The application of DPC and IAA-94 (blockers of cAMP-activated Cl- channel) into SV completely suppressed the forskolin-induced EP elevation, while niflumic acid (a Ca(2+)-activated Cl- channel blocker) failed to do so. IAA-94 applied into scala tympani (ST) did not suppress this EP elevation. The results suggest that adenylate cyclase may modulate the EP by changing Cl- transport between SV and scala media (SM) across Reissner's membrane.

Adenylyl Cyclases↗
PubMed1993

Carotid and vertebral rete mirabile in man--case report.

Rete mirabile is a normal vascular network in the carotid artery distribution of some vertebrates, but is an abnormal and extremely rare finding in humans. We describe a 40-year-old male with a carotid and vertebral rete mirabile manifesting as cerebrovascular disorder. This was the second case of carotid and vertebral rete mirabile in man.

Adult↗
PubMed1992

Adenylate cyclase modulation of endocochlear potential during suppression of strial Na(+)-K+ ATPase.

Forskolin, an adenylate cyclase activator, produces a reversible elevation of the endocochlear potential (EP) (Doi et al., 1990a). To determine whether strial Na(+)-K+ ATPase activity is essential for the forskolin-dependent EP elevation, we examined, by means of K(+)-selective microelectrodes, the effects of forskolin on the EP and the endolymphatic K+ activity ([K+]) while strial Na(+)-K+ ATPase was suppressed by ouabain. Perilymphatic perfusion with ouabain (10(-3) M) decreased the EP from 78.5 +/- 2.4 mV to -27.6 +/- 2.4 mV (N = 8) at 37.9 +/- 3.7 min after the start of perfusion and decreased the [K+] from 138.7 +/- 5.4 mM to 103.7 +/- 3.7 mM (N = 3). Successive perfusion with forskolin (2 x 10(-4) M) with ouabain (10(-3) M) increased the EP by 15.1 +/- 1.5 mV (N = 8) but did not influence the [K+] decrease from 101 +/- 3.6 mM to 95 +/- 1.3 mM (N = 3). Forskolin (2 x 10(-4) M) with ouabain (10(-3) M) without a preceding ouabain perfusion decreased the EP from 76.2 +/- 2.3 mV to -12.9 +/- 1.8 mV (N = 6) at 65.3 +/- 2.1 min after the start of perfusion. These results indicate that adenylate cyclase can modulate the EP in the absence of strial Na(+)-K+ ATPase activity and that adenylate cyclase activation can attenuate the EP drop induced by strial Na(+)-K+ ATPase suppression.

Adenylyl Cyclases↗
PubMed1992

Congenital alveolar adhesions.

We report an infant girl with congenital alveolar adhesions and a cleft palate. The mucosal bands were resected the day after birth. Stretching exercises of the mandible improved the range of movement at the temporomandibular joint. Two weeks of therapy were required before full mouth opening was possible. Previously reported patients and theories of embryogenesis are reviewed.

Alveolar Process↗
PubMed1991

[Combination chemotherapy with cisplatin and etoposide for cerebellar metastasis from ovarian adenocarcinoma].

A 54-year-old woman with cerebellar metastasis from ovarian adenocarcinoma was reported. Two years before admission, she underwent 7 courses of CAP therapy (cisplatin, adriamycin, cyclophosphamide) for ovarian cancer. On admission, no extracranial tumor was noticed. After the removal of a cerebellar tumor, she was treated by combination chemotherapy with cisplatin and etoposide. Her serum level of CA-125, which was still high after surgery, decreased to the normal level following chemotherapy. Chemotherapy was repeated six times, and no recurrence was noticed 1 year after surgery. Combination chemotherapy with cisplatin and etoposide was considered effective in the treatment of intracranial metastasis from ovarian cancer.

Adenocarcinoma↗
PubMed1989

Cleft palate in the Beckwith-Wiedemann syndrome.

Patients with the Beckwith-Wiedemann syndrome have numerous anomalies, varying somewhat from case to case. The most common presentation is exomphalos, macroglossia, and somatic gigantism. Although cleft palate in association with this syndrome has been rarely reported, we have observed 6 patients with cleft palate in 10 patients who were diagnosed with the Beckwith-Wiedemann syndrome. The literature is reviewed and discussed.

Beckwith-Wiedemann Syndrome↗
PubMed1989

Large encephalocele at the anterior fontanel--case report.

The authors report a newborn girl with a large meningoencephalocele, 18.5 cm in diameter, at the anterior fontanel. She had several accompanying anomalies, including microcephalus, cleft palate, and a uvula bifida. A plain skull x-ray revealed craniolacunia and a computed tomography (CT) scan showed maldevelopment of the cerebrum. The mass was resected, after which the fontanel was noted to bulge. CT demonstrated dilated lateral ventricles. A successful shunting procedure permitted the infant to leave the hospital in good general condition.

Cleft Palate↗
PubMed1989

[Tolosa-Hunt syndrome. Report of a surgical case].

A 58-year-old male presented with painful right ophthalmoplegia and was diagnosed as having Tolosa-Hunt syndrome. High-dose oral administration of a corticosteroid provided significant pain relief, but total ophthalmoplegia persisted. Computed tomography (CT) showed a tumor-like mass in the bilateral cavernous sinus. Angiography revealed occlusion of the right internal carotid artery. According to the literature, about 70% of cases of Tolosa-Hunt syndrome are caused by parasellar neoplasms. A transcranial biopsy of the patient's lesion revealed a nonspecific granulomatous process in the wall of the right cavernous sinus. He was again placed on high-dose corticosteroid therapy and within 1 week the right visual acuity improved slightly. The corticosteroid dose was gradually tapered over 3 months. After 2 months of therapy, the external ocular movement had almost fully recovered, although the light reflex was absent and the CT findings did not change.

Angiography↗
PubMed1988

Branchial cyst in the Beckwith-Wiedemann syndrome.

Patients with the Beckwith-Wiedemann syndrome have numerous anomalies, varying somewhat from case to case. A 2-year-old boy with the Beckwith-Wiedemann syndrome who had a branchial cyst is reported. The literature is reviewed and discussed.

Beckwith-Wiedemann Syndrome↗
PubMed1986

Arachnoid cyst in the quadrigeminal cistern.

Two cases of arachnoid cysts in the quadrigeminal cistern are presented, and one occurred in an adult. Signs and symptoms of increased intracranial pressure were noted, and obstructive hydrocephalus was shown by computed tomography scans in both cases. Arachnoid cysts in the quadrigeminal cistern have rarely been reported, especially in adults. The definition, classification, and etiology of arachnoid cyst are still confused in the literature, and various terms have also been used to indicate this particular location of cyst. In this study, these confusing problems are reviewed, and the usefulness of metrizamide computed tomographic cisternography is emphasized as a noninvasive method of diagnosis.

Adult↗
PubMed1982

[Vasculo-Behçet's disease with superior sagittal sinus thrombosis--case report (author's transl)].

The patient is a 30-year-old man who has suffered from recurrent attacks of tonsilitis, oral aphthae and scrotal ulcerations, erythema nodosum and thrombophlebitis. In April, 1980, he gradually developed headache and visual disturbance. On April 14, 1980, he was pointed out remarked bilateral choked disc by an ophthalmologist and then admitted to the Miyazaki Medical College Hospital. On admission to our service, he showed atypical symptoms of Behçet's disease, namely, oral aphthae and scrotal ulcerations, erythema nodosum and bilateral choked disc. Laboratory data demonstrated hyperimmunoglobulinemia, increased clotting factors and decreased fibrinolytic activity. Immunogenetically, HLA BW51 type was demonstrated. The angiograms showed complete obstructions of the superior sagittal sinus and the common trunk of the femoral artery. Histological examination of the skin lesion demonstrated atypical chronic inflammation and thrombophlebitis. A diagnosis of atypical Vasculo-Behçet's disease was made. The response to the steroid therapy was dramatic, though the fibrinolytic drugs, anticoagulants and vasodilators were not effective. Thrombophlebitis is a well recognized complication of Behçet's disease occurring in major vessels, however thrombosis of the dural sinus has rarely reported. This case may be the first one which had superior sagittal sinus thrombosis with Vasculo-Behçet's disease in literature. We discussed the mechanism of the thrombogenesis, the relationship to HLA, the coexistence of Neuro-Behçet's disease and the therapy of Vasculo-Behçet's disease.

Adult↗