Search PubMed⌕ Search

Biomedical subjects

I Kirsch

Publications and source records attributed to I Kirsch.

At least 55 records · Page 3Linked to original sources
PubMed1996

The effects of subject arm position and initial experience on Chevreul pendulum responses.

Some clinicians maintain that responses to the Chevreul pendulum illusion are facilitated by resting one's elbow on a table. Others claim the reverse. We compared these two methods in a counterbalanced crossover design by having 32 university students perform the Chevreul pendulum illusion with their elbows supported on a table and with their elbows unsupported. Although there was no main effect for method (elbow supported versus elbow unsupported), subjects who rested their elbows on a table on the first trial were more successful in responding on both trials. This suggests that supporting the elbow does facilitate responding, but only on the initial trial. Performance on subsequent trials is determined by degree of success on the first trial. Similar data from a previous study comparing different hypnotic inductions suggests that this phenomenon is generalizable beyond the Chevreul pendulum illusion and supports the hypothesis that the test-retest reliability of suggestibility scales may be due to a stabilization of response expectancy by a person's first experience of imaginative suggestions.

Adult↗
PubMed1995

Hypnosis as an adjunct to cognitive-behavioral psychotherapy: a meta-analysis.

A meta-analysis was performed on 18 studies in which a cognitive-behavioral therapy was compared with the same therapy supplemented by hypnosis. The results indicated that the addition of hypnosis substantially enhanced treatment outcome, so that the average client receiving cognitive-behavioral hypnotherapy showed greater improvement than at least 70% of clients receiving nonhypnotic treatment. Effects seemed particularly pronounced for treatments of obesity, especially at long-term follow-up, indicating that unlike those in nonhypnotic treatment, clients to whom hypnotic inductions had been administered continued to lose weight after treatment ended. These results were particularly striking because of the few procedural differences between the hypnotic and nonhypnotic treatments.

Anxiety Disorders↗
PubMed1995

Modifying hypnotizability: a new component analysis.

The effects of the Carleton Skills Training Program (CSTP) on hypnotizability were compared to those of a modified training program in which instructions for physical enactment of the response were omitted. After training, subjects in the original CSTP reported an increase in the extent to which they intentionally enacted suggested behaviors. In contrast, subjects in the modified training program reported increased fantasy without voluntary physical enactment. Nevertheless, both training programs increased behavioral and subjective responsiveness to suggestion, and there were no significant differences in response enhancement between the two programs. Across conditions, increases in behavioral and subjective responses to suggestion were correlated with increased use of fantasy. In contrast, increases in enactment were correlated only with compliance. The modified training program is recommended as a means of enhancing suggestibility with less likelihood than the original CSTP of engendering compliance.

Adult↗
PubMed1994

Clinical hypnosis as a nondeceptive placebo: empirically derived techniques.

Many psychological problems are maintained, in part, by dysfunctional response expectancies, and changing those expectations is an essential part of treatment. Hypnotic inductions alter response expectancies and have been shown empirically to substantially enhance the effects of psychotherapy. Therefore, hypnosis can be used therapeutically as a nondeceptive placebo. Expectancy plays a major role in hypnotic inductions and their effects. Clinical procedures suggested by these data are explored.

Humans↗
PubMed1993

Do double-blind studies with informed consent yield externally valid results? An empirical test.

Subjective and physiological effects of caffeine were investigated via a 3 x 2 x 3 design that assessed independent and interactive effects of instructions (told caffeine versus told no caffeine versus not told whether beverage contained caffeine), actual beverage content (caffeine versus no caffeine), and time after ingestion (15, 30, and 45 min). Instructions affected alertness at 15 min after ingestion. Caffeine increased alertness at 30 min after ingestion and systolic blood pressure at 30 min and 45 min after ingestion. A highly significant instruction by drug interaction on tension was obtained at all measurement points, indicating an increase in tension only among subjects who knowingly received caffeine. Because people are generally informed of drug content in non-research settings, these data challenge the external validity of typical double-blind studies, in which subjects are informed of the possibility of receiving a placebo as part of the consent procedure.

Adolescent↗
PubMed1993

Response expectancy as a mediator of hypnotizability modification: a brief communication.

The role of response expectancy in bringing about increases in hypnotic susceptibility by use of the Carleton Skill Training Program (CSTP) was assessed with 27 subjects selected for their low hypnotizability scores. Subjects were randomly assigned to one of two conditions: 13 received the CSTP to increase their hypnotic susceptibility, and 14 received no training. In addition to assessing hypnotizability, hypnotic response expectancies were assessed before and after training. With pretreatment hypnotizability controlled, subjects in the training group scored significantly higher than control subjects on all self-report measures of hypnotizability but not on a measure of observed behavioral response. Changes in response expectancy were found to be highly correlated with changes in hypnotizability. With changes in expectancy controlled, no significant differences between the trained and control groups were found.

Adult↗
PubMed1993

Two new Drosophila genes related to human hematopoietic and neurogenic transcription factors.

We have identified two new basic domain helix-loop-helix (bHLH) genes in Drosophila melanogaster, DroSCL and DroNHLH. DroSCL was identified because of its homology to the mammalian hematopoietic transcription factor SCL. DroNHLH was similarly identified by homology to NHLH1 and NHLH2, two bHLH genes expressed in the developing mammalian nervous system. A partial DroSCL complementary DNA clone was obtained from an early pupal (5.5-7.5-day) Drosophila library. DroSCL is 73% identical to SCL within the 55-amino acid region of the bHLH domain. A DroNHLH complementary DNA clone was obtained from an early instar (I and II) Drosophila library. Its coding region consists of 162 amino acids and encodes a predicted protein of 18,312 daltons. DroNHLH is 87% identical to NHLH1 and NHLH2 within the bHLH domain. DroSCL and DroNHLH are located on the X chromosome. A 1.7-kilobase DroSCL transcript and a 1.5-kilobase DroNHLH transcript were detected by Northern analysis of total Drosophila RNA. Examination of Drosophila embryos by tissue in situ hybridization reveals restricted expression of both genes in a subset of cells in the developing central nervous system.

Amino Acid Sequence↗
PubMed1992

Expert judgments of hypnosis from subjective state reports.

Suggestibility was assessed in 60 college students after a traditional hypnotic induction, an alert induction, progressive relaxation training, or instruction in goal-directed imagery. Responsiveness to suggestion did not differ between groups. Subjects also generated open-ended reports of their states of awareness and of their experience of 3 hypnotic suggestions. A sample of these reports from 24 moderately to highly suggestible subjects were evaluated by 18 experts in the field of hypnosis. Expert ratings of subjects' open-ended reports indicated that (a) traditional hypnotic inductions produce a state of consciousness that is indistinguishable from nonhypnotic relaxation training, (b) the subjective experience of hypnotic suggestions after imagination training is indistinguishable from that after hypnotic inductions, and (c) suggestibility is unrelated to state of consciousness as assessed by experts.

Adult↗
PubMed1992

Interpretive sets, expectancy, fantasy proneness, and dissociation as predictors of hypnotic response.

College students with no prior experience of hypnosis were assessed for fantasy proneness and dissociation. In a totally separate context, they were subsequently tested for their interpretations of hypnotic suggestions, hypnotic response expectancies, and hypnotizability. Contrary to Spanos and Gorassini's (1984) hypothesis, strategic enactment of suggested responses was rarely reported, and its endorsement was not correlated with hypnotic responsiveness. Suggestibility was significantly predicted by fantasy proneness and response expectancy, but not by dissociation. A path analysis suggested that the relation between fantasy proneness and hypnotizability was partially mediated by expectancy.

Adult↗
PubMed1991

Cognitive mediators of pain perception and tolerance.

A social learning model of pain perception and tolerance was evaluated. Responses to cold-pressor pain were examined in 4 groups of 20 Ss each. One group was given instruction in cognitive coping strategies, the 2nd was given a monetary incentive contingent on tolerance time, the 3rd was given both cognitive training and monetary reinforcement, and a no-treatment control group was given neither. Incentive and coping instructions significantly increased tolerance but did not alter pain perception. A path analysis indicated that pain tolerance was affected by self-efficacy, which in turn was predicted by pain expectancy and the provision of incentives. Incentive also had an impact on tolerance that was independent of self-efficacy. Pain perception was strongly affected by pain expectancy, but was unrelated to self-efficacy.

Adaptation, Psychological↗
PubMed1990

Subjective scoring for the Harvard Group Scale of Hypnotic Susceptibility, Form A.

A scale is presented which assesses subjective experiences associated with the test suggestions contained in the Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:A) of Shor and E. Orne (1962). This scale, along with the standard HGSHS:A self-scoring test booklet, was administered to 479 students at the University of Connecticut and 618 students at North Dakota State University, and normative data from these samples are reported. Correlational analyses indicated that the scale was both reliable and valid as a measure of hypnotic responsiveness. It is suggested that it may be useful to supplement behavioral scoring of hypnotizability with subjective scoring.

Adult↗
PubMed1990

Therapeutic outcome of patients suffering from malignant melanomas of the conjunctiva.

Eighty-one cases of conjunctival melanoma treated between 1960 and 1988 were studied to determine factors that might affect outcome in patients with such lesions. The therapeutic procedures performed were local excision (16), local excision followed by brachytherapy with Sr-90/Y-90 (32), local excision followed by cryotherapy with liquid nitrogen (16), brachytherapy with Sr-90/Y-90 (12), local excision followed by external beam irradiation (3), and local excision followed by brachytherapy and cryotherapy (2). The median follow-up period was 5.5 years (longest 26, shortest 1 year). Sixty two patients (76.5%) showed a complete regression of the melanoma, 19 (23.5%) developed recurrences, and 15 (18.5%) died from metastases. The melanomas had developed with almost equal frequency from a pre-existing naevus (25.9%), from primary acquired melanosis (25.9%), and 'de novo' (30.9%). Small tumours had a higher chance of regressing (80.6%) than larger ones (68.6%). The cumulative survival rate was 76% after five years and 60% after 10 years from any causes of death and 87.6% after five years and 76.3% after 10 years from deaths caused by metastases. Most deaths from metastases occurred within 5 years. At 88.5%, the cumulative survival rate of patients with small tumours (less than one quadrant of the bulbar conjunctiva and less than 2 mm thickness) was significantly higher than that of patients with larger tumours (more than one quadrant of the bulbar conjunctiva and/or more than 2 mm thickness) with 65% after eight years. Local excision followed by beta ray irradiation (Sr-90/Y-90) or cryotherapy can be recommended as the treatment of choice. Nevertheless the behaviour of conjunctival melanomas remains unpredictable in individual cases.

Adult↗
PubMed1990

Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.

An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion within the fifth intron of the c-sis gene. The normal c-sis gene has an Alu sequence in this region which includes two perfect 130 nucleotide repeated sequences separated by 5 bp. The deleted c-sis allele is missing precisely one copy of the 130 bp repeat and the intervening 5 bp. An identical deletion was also found in DNA from 1 of 13 sporadic meningiomas.

Alleles↗
PubMed1989

Antiimmunoglobulin inhibition of Burkitt's lymphoma cell proliferation and concurrent reduction of c-myc and mu heavy chain gene expression.

We have demonstrated that polyvalent antiimmunoglobulin antibodies directed at appropriate cell surface light (L) or heavy (H) immunoglobulin (Ig) chains will inhibit proliferation and the expression of c-myc and mu-Ig chain mRNA in Burkitt's lymphoma (BL) cell lines bearing 8;14 chromosomal translocations. This effect was not observed in BL cell lines bearing 8;22 translocations or in BL cell lines which did not express surface Ig or in karyotypically normal Epstein-Barr virus-transformed lymphoblastoid cell lines. The antiproliferative effect was reproducible and resulted in cell death in the most sensitive cell lines. The decrease in gene expression preceded the antiproliferative effect. The effect of anti-Ig on gene expression was relatively specific since the level of total (shown by Northern blots) and cytoplasmic (dot blots) mRNA of several other genes (beta-actin, G6PD, kappa-L chain) and the first exon of c-myc (in cell lines in which this exon is expressed separately from the second and third exons) was not changed in these same BL cell lines. Expression of both c-myc and mu was maximally inhibited between 3 and 6 h after the addition of anti-Ig. In the most sensitive BL cell line, concurrent reduction in c-myc and mu mRNA was noted as early as 1 h after anti-Ig and the nadir of expression of these genes occurred at 3 h. These results indicate that the deregulated high constitutive expression of c-myc in some BLs can be down-regulated by anti-Ig resulting in inhibition of proliferation and cell death. In addition these data are consistent with the possibility that in at least some 8;14 bearing BLs the malignant transformation occurs in an immature B-cell undergoing antigen-independent differentiation.

Antibodies↗
PubMed1989

The surreptitious observation design: an experimental paradigm for distinguishing artifact from essence in hypnosis.

Administered a hypnotic induction and 5 standard hypnotic suggestions twice via audiotape to a group of high-hypnotizable subjects and a group of low-hypnotizable simulators. During the first administration, subjects were led to believe that they were alone. However, their behavior was surreptitiously recorded on videotape and observed on a video monitor. The second administration occurred in the presence of an experimenter who had not been informed of group assignment. When unaware that they were being observed, simulators were significantly less responsive to suggestions than they were when openly observed. In contrast, the behavior of nonsimulating subjects was not affected by the presence of an experimenter. These data indicate that the responses of highly hypnotizable subjects to standard hypnotic suggestions cannot be accounted for in terms of simple compliance with experimental demand.

Humans↗
PubMed1988

Stimulation of the beta-subunit of the IL-2 receptor induces MHC-unrestricted cytotoxicity in T acute lymphoblastic leukemia cells and normal thymocytes.

Recently, several laboratories have identified a novel protein(s) of 70,000 to 75,000 Da (IL-2R beta-subunit) that, when expressed with the p55 Tac protein (alpha-subunit), imparts high affinity IL-2 binding. Expression of the beta-subunit mediates acquisition of MHC-unrestricted cytotoxicity in large granular lymphocytes. We report that thymocytes and T acute lymphoblastic leukemia cells express the beta-subunit of the IL-2R in the absence of detectable alpha-subunit expression and that IL-2 induces acquisition of MHC-unrestricted cytotoxic activity in these cells through stimulation of the beta-subunit.

Child↗
PubMed1988

IL-2-dependent expansion of CD3+ large granular lymphocytes expressing T cell receptor-gamma delta. Evidence for a functional receptor by anti-CD3 activation of cytolysis.

The nature and function of the TCR on PBL of a patient with a chronic CD3+ large granular (LGL) proliferation was studied. Fresh peripheral blood from this individual was comprised of 80% lymphocytes, 65 to 75% of which were CD3+, CD8+, Leu-7+ LGL. Of these LGL, 72% initially expressed the TCR-alpha beta heterodimer, whereas 21% did not. Cytotoxicity directed against MHC-unrestricted targets was minimal. After several days of exposure to rIL-2, cytotoxic activity was greatly enhanced, correlating with a disappearance of CD3+ cells expressing the alpha beta heterodimer. Twelve days after rIL-2 exposure, the LGL expressed only TCR-gamma delta heterodimer in association with CD3 and alpha beta heterodimer expression could no longer be detected. The TCR/CD3 complex on these cells was demonstrated to be functional as anti-CD3 elicited an increase in cytoplasmic free calcium concentration, stimulated cytolytic activity, and stimulated granule enzyme secretion from the LGL.

Antigens, Differentiation, T-Lymphocyte↗