Common bile nevus of the upper lip--a possible relationship to Mongolian spot.
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Biomedical subjects
Publications and source records attributed to I Kikuchi.
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Stiff skin syndrome was first documented by Esterly and McKusick. We saw a patient with this disease, as well as another who had a similar condition but a somewhat different histology. These two patients shared heritable stiff skin, restricted joint mobility, and absent mucopolysacchariduria. In stiff skin syndrome, which may have two variants, skin biopsy demonstrates large cells stained metachromatically by toluidine blue. These cells are shaped like dermal melanocytes or rounded cells and their presence may be directly related to the deposition of mucopolysaccharide in the dermis. In some cases they may invade the deeper tissues. Two cases of stiff skin syndrome that were in the Japanese literature are also discussed.
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The cul-de-sac in which the nail is formed determines that it should grow outward instead of upward according to Kligman. This view was questioned by Baran based on clinical observations and review of the literature. A case of vertically growing ectopic nail of congenital origin indicated that the cul-de-sac was directed to the skin surface and the nail was growing vertically to the skin. The anatomy of the cul-de-sac, which may be influenced by local factors, appears to determine the direction of the nail.
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