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Biomedical subjects

I Khan

Publications and source records attributed to I Khan.

At least 199 records · Page 11Linked to original sources
PubMed1979

Cyclic AMP formation of isolated human corpora lutea in response to HCG - interference by PGF2 alpha.

Human corpora lutea of defined ages were excised at operation, cut into pieces and incubated in the presence of HCG, PGF2 alpha and PGE2 alone or in combination. Following incubation cAMP formation in tissue and medium was determined. HCG-stimulated tissue cAMP content was most pronounced at a corpus luteum age of 7-10 days after ovulation. This stimulation was antagonized by PGF2 alpha in corpora lutea older than 6 days. PGE2 stimulated cAMP formation per se and this effect was more pronounced when HCG and PGE2 were combined. A possible role for PGF2 alpha as a luteolytic substance in the human is suggested.

Adult↗
PubMed1979

Convention on psychotropic substances, 1971. The role and responsibilities of the World Health Organization.

1. The world community has realized as early as the beginning of this century that collective action between nations is to be more effective in controlling drugs of abuse. A number of international drug control treaties including the Single Convention on Narcotic Drugs, 1961, controls drugs primarily obtained from plant material (opium, coca leaves and cannabis) and synthetic analogues of morphine. The Convention on Psychotropic Substances, 1971, is aimed at controlling psychotropic substances and was formulated in Vienna in 1971. 2. The Convention on Psychotropic Substances, 1971, lays a great responsibility on the World Health Organization to recommend to the United Nations Commission on Narcotic Drugs notifications initiated by the World Health Organization, or by a party to the Convention, regarding international control.

International Cooperation↗
PubMed1978

Factors influencing the release of procoagulant-tissue factor activity from leukocytes.

Leukocytes stimulated with endotoxin generate a procoagulant (tissue factor) activity. Part of this procoagulant activity is released rapidly into the surrounding milieu, with maximum release occurring within 30 min incubation. Optimal release of procoagulant activity requires the presence of Ca ions in a concentration of 2.5 mM, a pH of 7-8, and a temperature of 37 degrees C. The released procoagulant activity is TFa as determined by the two-stage assay and the ability of an antibody to tissue factor to neutralize the procoagulant activity. The release of TFa is not parallel to LDH release. Release of TFa is inhibited by vinblastine and cytochalasin B.

Animals↗
PubMed1976

Evidence for a splenic release factor of platelets in chronic blood loss plasma of rabbits.

Rabbits subjected to chronic blood loss with iron supplementation raised their platelet count and megathrombocyte number 1.7 x and 2.1 x above baseline, respectively. In similarly treated splenectomized animals, no significant response was obtained. When chronic blood loss plasma was injected into recipient animals there was a rise in platelet count and megathrombocyte number of 1.8 x and 3.4 x respectively compared to animals injected with control plasma. In similarly treated splenectomized animals no such rise was obtained; neither was there a rise in platelet count or megathrombocyte number in intact recipient animals when chronic blood loss plasma was obtained from splenectomized animals. It is concluded that the thrombocytosis of chronic blood loss requires the presence of an intact spleen. The data suggest tha presence of a release factor which requires the spleen for its elaboration as well as expression.

Animals↗
PubMed1975

Microthrombocytosis and platelet fragmentation associated with idiopathic/autoimmune thrombocytopenic purpura.

Platelet volume distribution curves were obtained in 20 control subjects and in 21 patients with idiopathic/autoimmune thrombocytopenic purpura. A striking increase in microthrombocytes as well as megathrombocytes was noted in 86% of patients on one or more occasions, particularly in the prsence of severe thrombocytopenia. The entire spectrum of platelet volume distribution curves noted in patients could be reproduced experimentally in rabbits following intravenous injection of anti-platelet antibody. Differential centrifugation studies with control subjects revealed that microthrombocytes were light platelets and megathrombocytes were heavy platelets. Electron microscopy in patients with thrombocytopenia revealed that microthrombocytes were composed of intact small platelets as well as platelet fragments. It is concluded that severe peripheral destruction of platelets is associated with an increase in microthrombocytes as well as megathrombocytes.

Adolescent↗
PubMed1970

Study of the effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated uteri of hypophysectomized rats.

1. In intact rats progesterone (50 mg/kg) antagonized the effect of stilboestrol (100 mug/kg) on the vaginal smears and the uterine sensitivity. The uterine sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine was decreased by 6.8, 64 and 14.8 times, respectively, as compared with uteri removed after stilboestrol injections.2. Progesterone therapy in hypophysectomized rats also antagonized the effect of stilboestrol on the vaginal mucosa and on the uterine sensitivity to drugs. The sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine was decreased by 6.2, 50 and 14.5 times, respectively. Similar results were obtained on uteri removed from sham-hypophysectomized rats.3. On the basis of these results it is suggested that the hypophysis does not play any part in the desensitization of the myometrium to the oxytocic drugs and in the changes found in the vaginal mucosa after progesterone therapy.

Acetylcholine↗
PubMed1969

Effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated rat uterus preparations.

1. Progesterone treatment (50 mg/kg) in ovariectomized rats antagonizes the effects of stilboestrol 100 mug/kg on the vaginal mucosa and uterine weight; but the sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine is increased by factors 4, 11 and 3, respectively.2. In intact animals a similar progesterone treatment (50 mg/kg) antagonizes the effects of stilboestrol 100 mug/kg on vaginal smears, uterine weight and uterine sensitivity. The uterine sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine is, however, decreased by a factor of 2, 1.4 and 17.7, respectively.3. These experiments show that the ovary is essential for the desensitizing effects of progesterone. The suggestion is put forward that another substance is released from the ovary by progesterone.

Acetylcholine↗
PubMed1969

Combined effects of diphenyliodonium chloride, pine oils, and mustard oil soaps on certain microorganisms.

Bactericidal and bacteriostatic activities of an emulsion containing 10.0% (v/v) terpineol, 0.5% (w/v) diphenyliodonium chloride, 11.0% (v/v) ethyl alcohol, and 5.62% saponified mustard oil were tested against a number of different types of organisms. The bactericidal concentration for Salmonella typhosa was 1:400. In the presence of 5.0% horse serum, it increased to 1:250. The bacteriostatic concentration varied from organism to organism; Escherichia coli and Staphylococcus aureus required 4,000 mug/ml for complete bacteriostasis, whereas Corynebacterium diphtheriae, Salmonella paratyphi-A, and Shigella required only 2,000 mug/ml for complete inhibition. A 4.0% concentration of the emulsion killed the spores of Bacillus subtilis within 6 hr.

Bacteriological Techniques↗