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Biomedical subjects

I Kantola

Publications and source records attributed to I Kantola.

27 records · Page 2Linked to original sources
PubMed1991

Sleep disturbances in hypertension: a double-blind study between isradipine and metoprolol.

This was a comparison of the effects of isradipine and metoprolol on sleep apnea syndrome in 12 hypertensive men who were habitual snorers. Each patient received double-blind isradipine 1.25-2.5 mg twice daily or metoprolol 50-100 mg twice daily after a 4-week placebo period. Static charge-sensitive bed examination was performed during the placebo period and 5-7 weeks after starting treatment. The number of obstructive breathing patterns was increased by metoprolol in five patients, remained the same with isradipine in four, and was decreased by metoprolol in one patient and by isradipine in two. Obstructive patterns increased in the metoprolol group from 24 +/- 26% to 32 +/- 31% and decreased in the isradipine group from 21 +/- 23% to 19 +/- 25% (p less than 0.05, Mann-Whitney U test). Neither drug had a significant effect on blood pressure values. There was no significant difference in oxygen desaturation or in the amount of quiet sleep in either treatment group. On the basis of these results, it would appear that isradipine is more suitable than metoprolol for the treatment of hypertension in patients who are habitual snorers.

Adult↗
PubMed1983

Anaphylactic shock due to ingestion of psyllium laxative.

Psyllium, seed of Plantago ovata, is a major constituent of several bulk laxatives. There are several reports on its role as an occupational respiratory allergen. We describe a severe anaphylactic reaction caused by ingestion of psyllium laxative. The hypersensitivity to Plantago ovata was confirmed by skin testing and RAST. The possibility of hypersensitivity reaction to psyllium laxatives should be recognized and included in marketing information.

Adult↗
PubMed1981

Ruthenium red staining of blood-bubble interface in acute decompression sickness in rat.

The ultrastructure of the blood-bubble interface has been studied in rats decompressed experimentally. Subsequent to staining with ruthenium red there was detected by electron microscopy a continuous envelope like layer about 20 nm thick at the bubble-facing surface of the interface. The envelope like structure was visualized also by concanavalin A-ferritin, a glycosyl- and mannosyl residue-recognizing lectin coupled with an electron-dense probe, but the structure was not at all seen by the use of the conventional stains used in electron microscopy, uranyl acetate and lead citrate. No electron-dense layer was discernible on the application of only osmium tetroxide without further staining. The results indicate that material stainable by ruthenium red, and binding concanavalin A (probably a glycoprotein), is concentrated at the blood-bubble interface upon decompression. It is suggested that it plays a role in stabilization of the bubble and in the hematological alterations that are frequently observable in decompression sickness.

Animals↗
PubMed1980

Permeability changes in cerebral, iridic, and retinal vessels during experimental decompression sickness in the rat.

An investigation has been made of the effect of acute decompression sickness upon the permeability of the cerebral, iridic, and retinal vessels of the rat, with sodium-fluorescein as intravenous tracer. No permeability changes were observable during the first 15 min subsequent to decompression, following exposure to 5.1 bar for 50 min. Focal leaky areas were found in the brain parenchyma after exposures to 5.1 bar for 120 min. Although sodium-fluorescein partially permeated the pial vessels in controls, the treatment in a hyperbaric chamber seems to increase the diffusion of the tracer from the pia into the cerebral cortex. Nevertheless, both the iridic and retinal vessels remained "tight." The factors which increase the permeability of microvasculature in brain and possible reasons for the negative results obtained with the iris and retina in decompression sickness are discussed.

Air Pressure↗