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Biomedical subjects

I Kanno

Publications and source records attributed to I Kanno.

At least 145 records · Page 8Linked to original sources
PubMed1986

Relation between tissue nature and (18F) fluorodeoxyglucose kinetics evaluated by dynamic positron emission tomography in human brain tumors.

Using dynamic positron emission tomographic (PET) scans, kinetic rate constants in the (18F) fluorodeoxyglucose (18FDG) model and glucose consumption rate were measured in human brain tumors. In the tumor tissue, all rate constants were higher on the average in the glioma grade IV and the non-glial tumor groups. The k*3 showed wide deviation in the glioma grade IV group. Discrepancy was found between the k*3 and the glucose consumption rate in several cases. The k*1 correlated with the neovascularity in tumors confirmed at angiography. Analysis of the rate constants might be useful for interpreting tumor nature and predicting its malignancy.

Adult↗
PubMed1986

Cerebral glucose metabolic change after high-dose methotrexate treatment in patients with acute lymphocytic leukemia.

An investigation was carried out to study the changes in the cerebral metabolic rate for glucose (CMRGlc) after high-dose methotrexate infusion (HD-MTX) in leukemic children, compared with the rate before such treatment. This is the first report on the relation between HD-MTX and the CMRGlc. An infusion of HD-MTX significantly reduced the glucose metabolism. It is suggested that this depression of the CMRGlc may have been associated with acute neurotoxicity of MTX. Measurement of the CMRGlc may be of value in detecting neurotoxicity of MTX. The reasons for these metabolic alterations need further investigation.

Adolescent↗
PubMed1986

Positron emission tomography in patients with a primary intracerebral hematoma.

Using positron emission tomography, the regional cerebral blood flow (CBF), oxygen extraction fraction (OEF) and oxygen consumption (CMRO2) were studied in 21 patients with hypertensive intracerebral hematomas. The study showed a very localized decrease of CBF and CMRO2 around a hematoma, and revealed in two cases (9.1%) distinct luxury perfusion around it. There was diffuse reduction of CBF with increased OEF in hematomas larger than 4.5 cm in diameter. The results suggested that surgical evacuation should be considered for hematomas with a diameter exceeding 4.5 cm.

Adult↗
PubMed1986

Regional cerebral blood flow and metabolism in patients with chronic obstructive carotid disease.

Regional cerebral blood flow (CBF), oxygen extraction fraction (OEF) and oxygen consumption (CMRO2) were studied by PET in 26 patients with chronic occlusion(s) or severe stenosis of the internal carotid or middle cerebral artery(ies) without a large (greater than 2 cm) infarction. Most of them showed a coupled decrease of CBF and CMRO2 in the internal carotid distribution. In 5 patients (19%), the CBF in the least perfused but structurally normal tissue was reduced to critically low values while maintaining CMRO2, considerably increasing OEF. Since detection of a lesion with hemodynamic insufficiency was important for the indication for an EC/IC bypass operation, only 19 per cent of the present series would have had an indication for surgery.

Blood Volume↗
PubMed1986

Deadtime correction method using random coincidence for PET.

A deadtime correction method is proposed for quantitative measurements in positron emission tomography. The correction is based on the observation that a deadtime loss of the random coincidence events corresponds to that of the single events and of the total coincidence events. Using the proposed correction method, the deadtime loss was kept within 1% up to the true coincidence rate of 50 X 10(3) cps per plane for a cylindrical phantom of 20 cm in diameter. Accuracy of the method is confirmed to be independent of the size of the object.

Brain↗