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Biomedical subjects

I Kane

Publications and source records attributed to I Kane.

6 recordsLinked to original sources
PubMed1992

Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement.

Mutations in the protein transthyretin cause amyloidosis involving the heart, peripheral nerves, and other organs. A family from West Virginia developed an unusually aggressive form of widespread transthyretin amyloidosis. Single-strand conformation polymorphism analysis revealed a variant in the transthyretin gene, which was found on sequencing to be a T----C transversion at position 2 of codon 55, corresponding to a Leu----Pro substitution. The variant sequence was confirmed by restriction analysis and polymerase chain reaction (PCR)-primer introduced restriction analysis.

Amyloidosis↗
PubMed1984

[Anti-BCG titers of healthy and tuberculous Africans. Use of the indirect immunoperoxidase test].

This study was intended to assess the presence of antibodies to BCG: immunoglobulin G (IgG) and immunoglobulin M (IgM) in three homogenous african populations: 76 tuberculous patients, 55 adult healthy subjects and 46 newborn. We have used an indirect immuno-peroxidase reaction. Tuberculous patients were clearly distinguished from the other two groups by raised IgG titres, associated with severe clinical and radiological features. In the control population, the IgG anti-BCG were also present, but to a lesser degree. The IgM anti-BCG were seen in high titres (greater than 20 in this study) in healthy adults and patients. The two populations differed significantly (p less than 0.001), nevertheless some healthy adults achieved IgM titres comparable with tuberculous patients. This simple test could be an interesting contributory factor in cases of diagnostic difficult and enables a serological assessment of patients having BCG therapy.

Adolescent↗
PubMedDate not supplied

Correlating nursing care, nursing practice, and nursing performance standards.

All too often nursing standards have been viewed as a cumbersome paperwork task with little day-to-day practical relevance. Using a matrix approach that incorporates nursing role functions and the nursing process, the authors developed a model that provides the basis for job descriptions, performance appraisals, peer review, and quality management activities.

Employee Performance Appraisal↗