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Biomedical subjects

I Kan

Publications and source records attributed to I Kan.

7 recordsLinked to original sources
PubMed2005

Integral therapeutic potential of bone marrow mesenchymal stem cells.

Bone marrow derived mesenchymal stem cells (MSC) are adult stem cells that reside within the bone marrow compartment. In the traditional developmental model, adult stem cells are able to differentiate only to the tissue in which they reside. Recent data have challenged the committed fate of the adult stem cells, presenting evidence for their multi-lineage differentiation potential. In addition, potential therapeutic benefits of MSC administration have been the main concern of much research, including clinical trials. These studies promote adult stem cell therapy by shedding some light on the therapeutic potential of MSC and their mechanism of action. Many doubts have found their way into MSC research. They question MSC potency and beneficial contribution. However, these obstacles should not arrest but set a challenge to MSC researchers to examine their achievements under a magnifying glass. Therapeutic benefits of MSC exogenous delivery do not run counter to its possible participation in endogenous repair. Several reports imply MSC involvement in physiological repair but no explicit data support this hypothesis. This review tries to put MSC research into perspective. Possible therapeutic applications of MSC therapy for damaged tissue replacement, tissue engineering and the underlying repair mechanisms will be discussed. In addition, reported data about MSC possible involvement in physiological multiple tissue repair, their homing to injury and site-specific differentiation will be presented.

Animals↗
PubMed2000

A patient with primary biliary cirrhosis associated with autoimmune hemolytic anemia.

Primary biliary cirrhosis is often associated with autoimmune conditions, such as thyroid disease, sicca complex, and rheumatoid arthritis. However, an association with autoimmune hemolytic anemia has rarely been reported. We present a case of primary biliary cirrhosis associated with warm type autoimmune hemolytic anemia, and we review prior reports.

Aged↗
PubMed1995

[Left ventricular pseudoaneurysm at the apex--a case report of successful resection of the enlarging pseudoaneurysm following mitral valve replacement, which was caused by closed mitral commissurotomy 23 years ago].

A 47-year-old male with pseudoaneurysm of the left ventricle secondary to mitral valve replacement was herein reported because of its unique etiology. The pseudoaneurysm was presumably resulted from the mitral valve dilator wound at the apex of the left ventricle, which was produced by closed mitral commissurotomy 23 years ago. To our knowledge, it seems to be a rare reported case with pseudoaneurysm of the left ventricle caused by closed transventricular mitral commissurotomy.

Aneurysm, False↗
PubMed1985

Cytologic investigation of human in vitro fertilization failures.

A cytogenetic study of unsuccessfully fertilized oocytes was done for information on the frequency and type of chromosomal abnormalities leading to preimplantation loss. Of 72 oocytes, 44 were assessed as mature, 19 as intermediate, and 9 as immature. The mean fertilization rate was 68%. This rate was significantly lower in immature oocytes than in mature ones (22% versus 79%). Immature oocytes completed maturation in vitro up to metaphase II of meiosis. Intermediate oocytes became fertilizable, however, a significant proportion showed morphologic abnormalities after fertilization. Thus, eggs with three pronuclei were hypotriploid or had three prophasic chromosome sets, together with polyspermy and with first polar body chromosomes. Eggs with developmental arrest showed marked asynchrony in pronuclear morphogenesis. One had a chromosome complement of 24,XX. It is concluded that insemination prior to completion of maturation leads to abnormal development.

Adult↗