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Biomedical subjects

I K Okhotin

Publications and source records attributed to I K Okhotin.

At least 19 recordsLinked to original sources
PubMed1988

[Ways of improving the diagnosis and prognosis in vasorenal hypertension].

Atherosclerosis, aorto-arteritis and fibromuscular dysplasia are the most common causes of vasorenal hypertension. Determination of plasma renin activity is a valuable diagnostic test at early stages of vasorenal hypertension. HLA studies demonstrated significantly elevated antigens B8 and B12 in patients with essential hypertension, and antigen A9 in patients with affected renal arteries. These findings may expand the possibilities of differential diagnosis for the selection of patients, eligible for angiographic investigation. A less than three-years duration of the disease in the presence of high plasma renin activity is a favorable prognostic criterion.

Adolescent↗
PubMed1987

[Fibronectin level of the blood plasma of patients with congenital heart defects].

Enzyme immunoassays have shown mean fibronectin (FN) level to be 241.0 +/- 15.1 micrograms/ml in normal children between 2 and 15 years of age. Similar assays in 57 patients with congenital heart diseases (CHD) before and after surgery demonstrated preoperative FN decrease in 56% of patients, that was directly related to the extent of hemodynamic disorders, while postoperative FN level depended on the range and type of surgical trauma and the presence of inflammatory or suppurative-septic complications. Within 3 postoperative days, FN drops below normal level in 95% of patients. In spite of therapeutic use of blood and blood components, FN deficiency was not compensated for until day 10 after surgical correction of the valvular defect.

Adolescent↗
PubMed1986

[T and B lymphocyte function of patients with infectious complications after surgery for congenital heart defects].

The parameters of T- and B-lymphocyte system were studied in 65 patients with congenital heart defects aged from 2 to 31 years with infectious complications after operation. The investigation was performed before operation and in the course of the postoperative period. Patients with infectious complications were shown to have more considerable suppression of cell and humoral immunity before operation than those without infectious complications. The parameters concerned were found to be distinctly decreased in the early postoperative period. Two weeks after operation no normalization of the immune parameters were noted.

Adolescent↗
PubMed1986

[Echocardiography in the diagnosis and evaluation of the results of the surgical treatment of interatrial septal defects in adult patients].

Pre- and postoperative echocardiographic findings in 67 patients above 18 years of age with atrial septal defects were compared with hemodynamic data obtained at catheterization of heart cavities. No possible ways of accurate noninvasive assessment of arteriovenous discharge were found. Echocardiographic parameters of the followed-up patients returned to normal within 3 to 4 years after surgical correction of the defect. In some cases where mitral prolapse was found preoperatively, angiographically documented mitral regurgitation was seen at long-term follow-up.

Adolescent↗
PubMed1980

[Experience with repeated operations in the late periods after aortic prosthesis for coarctation].

Six repeated operations were performed in periods of one and a half to thirteen and a half years after aortic prosthetics in five patients and shunting in the region of the coarctation in one patient. Severe deformity of the prostheses was revealed during the operation in all cases. Total normalization of the correlation between arterial pressure on the upper and lower extremities was achieved in five persons as a result of the operation. The causes of deformities of the prostheses, the peculiarities of the technique of repeated operative interventions, the methods for correcting circulatory disorders and the indications for reoperations are discussed.

Adolescent↗
PubMed1978

[Indications for hypothermia in the surgery of congenital heart defects and the results of its use].

The authors operated 1056 patients on "dry" heart under the conditions of hypothermia. The total lethality constituted 4.5%. Since 1970 they have been applying craniocerebral hypothermia method using the apparatus "Kholod-2F". Secondary failures of the interatrial septum and valve stenosis of the pulmonary artery in patients aged from 18 to 20 are the most common indications for operation. 450 and 248 patients, respectively, were operated upon; lethality was 3.7% and 4%. The 16 years' experience with the superficial hypothermia in the correction of congenital heart diseases has proved this method to be highly effective and economical one, allowing to obtain quite favourable results after a thorough preoperative diagnosis and strict selection of patients.

Adolescent↗
PubMed1976

[Surgical treatment of aortic coarctation in adults].

During a 18-year period the authors operated 305 patients with aortic coarctation, the mortality being 2.2%. Sixty three patients (20.6%) aged from 20 to 40 years were operated upon with the mortality in 7.9%. A direct anastomosis of the aorta was constructed in 31 patients, alloprosthesis of the aorta was employed in 23 cases, indirect isthmoplasty--in 8 cases, in one case an aortic prosthesis was replaced. The most frequent intra- and postoperative complication was intrapleural hemorrhage. In estimating the efficacy of surgery within the terms up to 14 years the best results were obtained after an end-to-end anastomosis.

Adult↗
PubMed1975

[Surgical treatment of patent ductus arteriosus].

The experience gained with 1400 operations for patent ductus arteriosus performed at the Clinic of the Hospital Surgery of the Gorky Medical Institute during the period from October 1955 through 1973 is presented. The total post-operative lethality comprised 1.3 per cent, it amounting to 6 per cent with complicated patent ductus arteriosus, to 3 per cent among children of junior age and to 0.1 per cent in cases of uncomplicated defect. An analysis of operative and post-operative complications along with a study into remote results of the surgical intervention helped define indications for the closure of the duct in patients with pulmonary hypertension and septic endarteritis. They also showed the possibility of a single-stage correction of combined congenital heart defects. Indications have been worked out for the surgical treatment of patent ductus arteriosus in infants and procedures for the closure of the duct, depending upon its apatomic variants and concomitant complications.

Adolescent↗