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Biomedical subjects

I K Malashenkova

Publications and source records attributed to I K Malashenkova.

7 recordsLinked to original sources
PubMed1996

[Drug intolerance].

The authors present experimental data on luminol-dependent neutrophil chemiluminescence of blood from patients with drug intolerance. A decrease in intensity of neutrophil and whole blood chemiluminescence was registered in the presence of intolerated drugs. In acute phase of generalized intolerance reaction the chemiluminescence test showed readiness of the blood cells to react inadequately to the contact with different drugs leading to variations in generation of active oxygen forms. Improvement in patients' condition was followed by narrowing spectrum of drugs causing a decrease in the intensity of the chemiluminescence. Later, the chemiluminescence ratio remained low in testing only those drugs causing intolerance reaction.

Blood Donors↗
PubMed1989

[Treatment of patients with hypertonic disease with plasmapheresis].

The paper presents a discussion on therapeutic results obtained with plasmapheresis treatment in 16 patients with stage II essential hypertension. Thirty-three comparable patients entered a control group of conventional treatment. The test and control patients with stage II hypertension were examined for time-course changes in T- and B-lymphocytes counts, the activity of the energetic enzymes (alpha-glycerophosphate dehydrogenase, succinic dehydrogenase, lactate dehydrogenase), serum immunoglobulins and circulating immune complex levels. It was established that the standard antihypertensive treatment failed to restore normal parameters of immunity and to favor positive alterations in the activity of the enzymes in the blood lymphocytes, whereas therapeutic plasmapheresis was found to stimulate immunity, especially cellular one. This occurred in line with a rise in the levels of lymphocytic dehydrogenases.

Adolescent↗
PubMed1985

[The course of ischemic heart disease in rheumatic defects in persons over 45].

Coronary heart disease (CHD) was followed up in 239 patients with rheumatic heart disease. According to the clinical data 40 (16.73%) patients had myocardial infarction (MI), 100 (41.84%) cardiosclerosis (CS), 185 (77.4%) angina pectoris (AP). AP (44.35%) prevailed among the isolated (66.1%) forms of valvular disease, associated AP and CS (23%) among the combined (33.9%) forms. In the majority of patients, AP originated and ran its course as stable throughout many years; in one-fifth of patients, the disease occurred as unstable. The incidence of AP was significantly higher in the senior age group, in women with aortic valvular disease, in men with stage III circulatory failure, and in cardiomegaly, AP aggravated the disease and life prognosis. MI was manifested by a moderately pronounced painful attack; it was frequently complicated by acute or incremental chronic circulatory failure. Small-focal MI was seen more frequently while the electrocardiographic changes associated with the disease resembled those seen in rheumatic carditis. Postinfarction CS stimulated the onset and progress of chronic congestive heart failure in 93.02% of patients.

Aged↗