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Biomedical subjects

I K Kim

Publications and source records attributed to I K Kim.

At least 73 records · Page 4Linked to original sources
PubMed1992

Support exchange patterns of the elderly in the Republic of Korea.

The authors examine support of the elderly in South Korea, with a focus on the future implications of demographic aging. "Owing to socio-economic development in the Republic of Korea and the country's success in reducing mortality and fertility, the proportion and number of elderly in the population is rapidly rising. Co-residence with adult children is the most important pattern of support for the elderly. But the elderly also contribute support in the form of financial and material assistance as well as services such as care of grandchildren. The article concludes that, because of the rapid increase in the absolute size of the elderly population, government services need to be expanded to assist in providing care for the elderly."

Adult↗
PubMed1991

Studies on the prenatal chromosomal analysis and the changes of maternal serum alpha-fetoprotein following chorionic villus sampling.

Transcervical chorionic villus sampling (CVS) was performed in 174 patients between 7 & 12 menstrual weeks of pregnancy opting for prenatal diagnosis. Advanced maternal age was the most common indication for CVS (39.7%). The sampling success rate was 95.4% (166/174), representing 88.9% at 7 to 8 weeks, 98.9% at 9 to 10 weeks & 92.7% at 11 to 12 weeks gestation. In 139 of 174 patients (80%), successful sampling was accomplished in one or two catheter passages only. Four spontaneous fetal losses (2.3%) occurred. The cytogenetic analysis routinely used was the direct overnight & long-term culture methods which revealed 4 abnormalities (2.4%). To date, 90 of the women have been delivered & all infants are doing well and the remaining 65 pregnancies are continuing uneventually. Maternal serum alphafetoprotein (MSAFP) concentration was determined in 72 patients immediately before & after CVS. A significant increase of 20% or more, comparable to pre CVS levels, was noted immediately after sampling in 56 of 72 patients (77.8%). The increase in MSAFP concentration correlated with the amount of villi sampled (r = 0.498, p less than 0.001) & with the number of sampling attempts (p less than 0.05). Estimated CVS related fetomaternal hemorrhage (FMH) ranged from 0.005 to 0.1552 ml and in 5 of 72 patients (6.90%) 0.06 ml or more of FMH was noted. Two of the 5 patients had FMH of 0.1 ml or more.

Chorionic Villi Sampling↗
PubMed1991

A study on platelet function in idiopathic scoliosis.

Because platelets and muscle cells share the same contractile proteins--actin and myosin--platelets may serve as a model for muscle research. To study the functional abnormalities and ultrastructural changes of platelets and to determine whether or not abnormalities in muscle contractile proteins and collagen play an important role in the pathogenesis of idiopathic scoliosis, the bleeding time, the platelet aggregation test, and the titers of platelet plasminogen activator inhibitors were measured and the electron microscopic findings were examined in 52 idiopathic scoliosis patients aged 7 to 28 years and in 49 normal individuals aged 8 to 38 years as a control group. We found no statistically significant difference between the two groups in the bleeding time, the platelet aggregation test, and the titers of platelet plasminogen activator inhibitors. In the electron microscopic findings, no specific abnormalities were found in platelets of idiopathic scoliosis patients. We concluded that idiopathic scoliotic patients have normal morphology and function of platelets, and there is no important role of contractile proteins in the pathogenesis of idiopathic scoliosis. In addition, since the bleeding time was in the normal range, no evidence of subendothelial collagen dysfunction was found in the idiopathic scoliosis patients.

Adolescent↗
PubMed1990

[A method of managing the bronchial stump after surgical and combined treatment of patients with cancer of the lung].

The authors developed a complex of measures for the prevention of purulent bronchopleural complications, among which the "stumpless" method of manual treatment of the bronchus is the principal measure. With this method, the incidence of a bronchial fistula reduced to 0.5% in lobe-bilobectomy and to 1.4% in pulmonectomy. Due to the sharp drop in the incidence of this complication, the total postoperative mortality reduced to 3.3%. The developed methods of manual treatment of the bronchus made it possible to level out the difference in the incidence of a bronchial fistula in surgical and combined treatment (preoperative radiotherapy), 2.1% and 3.9%, respectively. The "stumpless" methods of manual treatment of the bronchus in lung carcinoma improve the conditions for oncological radicalism of the operation and prevent economical losses by reducing the hospital stay of patients.

Bronchi↗
PubMed1989

Red cell enzyme and serum protein polymorphisms in South Korea.

Two population groups in South Korea, one from Kwangju and one from Kangreung, were studied in regard to the erythrocyte enzyme polymorphisms GPT, ACP, GLO, ESD, 6PGD, ADA, AK, PGP and subtypes of PGM1 as well as regarding the serum protein variants of C3, HP, BF, PLG, AMY and the subtypes of GC, TF and PI. The results were compared with data of the population groups from the area of Cheju Island, Taejon and Seoul. The Korean population showed a rather high degree of genetic homogeneity.

Adolescent↗
PubMed1989

The effect of genetic counseling on performance of prenatal cytogenetic diagnosis.

Currently the number of pregnant women who have indications for, but do not receive, prenatal cytogenetic diagnosis is increasing. The purpose of this study was to review the prenatal cytogenetic services and to analyze the effect of genetic counseling on performance of the prenatal cytogenetic test. From January 1987 to July 1988, there were 2,796 deliveries at Severance Hospital, Yonsei Medical Center, of which 126 patients had indications for prenatal cytogenetic diagnosis. Chromosomal abnormalities were found in 5 patients (1, monosomy X; 1, trisomy 18; and 3, trisomy 21). Four patients were found in the group who had indications for prenatal cytogenetic diagnosis while only one was found in the group who did not (p less than 0.01). The most common indication for prenatal cytogenetic diagnosis was advanced maternal age (59%). The prenatal test rate was highest in patients whose indications were a previous child with chromosomal abnormality (100%) and parental translocation carrier (100%). Most (89%) of the patients were tested by amniocentesis between the 16th and 20th week of gestation. The two most common reasons for patients not receiving a prenatal cytogenetic diagnosis were late registration (41%) and absence of genetic counseling (34%).

Abnormalities, Multiple↗
PubMed1988

Preoperative radiotherapy in the combined treatment of lung cancer patients.

The results of a cooperative study on combined treatment and preoperative radiotherapy in 478 lung cancer patients were analyzed. Intensive fractionated radiotherapy was given at doses of 4 Gy for 5 days, the total dosage thus attaining 20 Gy. 218 patients received combined treatment, 260 patients were treated only surgically. A comparison of the 5-year survival rates of Stage I and II patients did not show any advantage in favor of the used therapeutic modality. The combined treatment with preoperative radiotherapy, however, improved the survival rates of Stage III patients with non-small cell lung cancer. The 3-year rate in these patients was 49.4% and the 5-year rate was 29.2%, while those found in the patients treated only surgically were 28.1% and 15.8%, respectively. In all patients with regional metastases the effectiveness of the treatment was higher when the combined method was employed.

Clinical Trials as Topic↗
PubMed1986

[Multiple primary cancer of the lung and larynx].

An experience of treatment of 43 cases of primary multiple cancer of the lung and larynx (synchronous--9, metachronous--31 and metachrono-synchronous--3) is discussed. Patients with lung and laryngeal cancer should undergo thorough examination. Primary multiple malignancies of the said organs make the case for surgery.

Adenocarcinoma↗
PubMed1985

[Surgery in the treatment of patients with small cell lung cancer].

The data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. The findings on survival time make the case for surgery as a component of combined treatment of tumor. The best results were obtained in cases of stage I and II tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery followed by chemotherapy.

Adult↗
PubMed1985

[Multiple primary cancer in 1 lung].

The experience gained in the treatment of 29 cases of primary multiple carcinomas of one lung (synchronous--20 and metachronous--9) was analysed. Criteria for diagnosis of primary multiple neoplasms as well as choice of treatment are discussed. Surgical excision of both tumors was performed in 27 cases (synchronous--19 and metachronous--8). Surgery proved to offer considerable advantage in treatment of the lesion.

Aged↗
PubMed1984

Biological activity and a modified synthesis of 8-amino-3-beta-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, an isomer of formycin.

A two-step synthesis of 8-amino-3-beta-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine (3), which is an isomer of formycin that resembles 3-deazaadenosine, is reported. Compound 3 is also described as as being a very poor substrate for adenosine deaminase and to be both a competitive and an irreversible inhibitor of S-adenosylhomocysteinase in the synthesis direction. L1210 cell growth in culture was inhibited by 3. Compound 3 was not converted to the nucleotide level in erythrocytes but was found to inhibit both the cellular uptake of nucleic acid precursors and their incorporation into the nucleic acids of L1210 cells. Finally, 3 was found to be a weak antiviral agent and coronary vasodilator.

Adenosine Deaminase↗