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Biomedical subjects

I K Fry

Publications and source records attributed to I K Fry.

At least 37 records · Page 2Linked to original sources
PubMed1979

Acute renal failure due to bacterial pyelonephritis.

Five patients who presented with acute renal failure in association with urinary tract infection are reported. Renal function improved rapidly on antibacterial therapy and no alternative cause for acute renal failure could be identified. None had previously been known to have renal disease but three of the five had taken considerable amounts of analgesics. The unusual severity of renal functional impairment resulting from urinary tract infection in these patients is unexplained but may relate to previous analgesic abuse and/or delay in treatment. Since acute non-obstructive pyelonephritis may result in severe reversible renal failure, this diagnosis must be considered in patients presenting with acute uraemia.

Acute Kidney Injury↗
PubMed1978

The effect of osmotic diuresis on urinary iodine concentration using contrast media of differing osmolality.

The urinary iodine concentrations of a monomer (sodium iothalamate), a dimer (sodium iocarmate) and a non-ionic compound (metrizamide) have been compared in dogs with varying levels of solute excretion. All the animals were undergoing maximal antidiuresis. In dogs with normal solute excretion, metrizamide and iocarmate produced higher urinary iodine concentrations than iothalamate. There was no significant difference between metrizamide and iocarmate. With increasing levels of solute excretion, the differences between the compounds were reduced. These findings suggest that contrast media of reduced osmolality are unlikely to have a special place in advanced renal failure.

Animals↗
PubMed1978

Ioglycamide (Biligram) studies in man--relation between plasma concentration and billary excretion.

Plasma ioglycamide concentration was linearly related to the rate of intravenous infusion over a dose range of from 1 to 4 mg per kg per min. The relation between plasma and biliary concentration of ioglycamide was studied in 15 anicteric patients with a T-tube in situ. Peak biliary concentrations and excretory rates of ioglycamide were seen when the plasma concentration was greater than 1500 micrograms per ml. The mean biliary transport maximum (Tm) for ioglycamide in man was 31.6 mg/min (range 22.0-40.4). The results suggest that near optimal concentrations of iodine in the bile duct can be obtained during intravenous cholangiography if ioglycamide is infused for one hour at a rate of about 4 mg per kg per min.

Bile↗
PubMed1978

Ioglycamide (Biligram) studies in man. Radiological opacification of the bile duct. A comparison of a number of different methods.

Intravenous cholangiography was carried out in 80 anicteric patients using ioglycamide (Biligram). Twenty patients were given a 30 ml ampoule of 35% ioglycamide as a slow hand injection over ten minutes; the remainder were given ioglycamide by one hour slow drip infusion at a rate of 2, 3, or 4 mg per kg body weight per minute. The radiological opacification of the bile duct was then assessed independently by two radiologists. There was a statistically significant difference between the bile duct opacification found in patients given either 3 or 4 mg/kg/min of ioglycamide for one hour compared with those given ioglycamide either by ten minute injection or by 2 mg/kg/min drip infusion.

Adult↗
PubMed1977

The obstructed kidney: correlation between renal function and urodynamic assessment.

In 20 patients with pelvi-ureteric junction obstruction the results of quantification of the change in renal pelvis size during high-dose intravenous urography with a diuretic, pressure/flow studies, standard renography and deconvolution analysis of the gamma camera renogram have been compared. The results of high-dose intravenous urography and pressure/flow studies correlated well. Renography was unreliable in diagnosing obstruction unless deconvolution analysis of the gamma camera renogram was used to differentiate those showing an obstructive uropathy from those with an obstructing nephropathy.

Humans↗
PubMed1975

Excretion urography toxicity studies in experimental acute renal failure.

Studies have been carried out on the toxicity of large doses of contrast medium (Hypaque 45%) given to rats with acute renal failure induced both by mercuric chloride and by glycerol. No increase in the expected mortality of the experimental models was observed following infusion of twice the maximum clinical dose of contrast medium.

Acute Kidney Injury↗
PubMed1975

An anomalous calyx in the mid-kidney: an anatomical variant.

Three cases in which there was an anomalous short calyx without a papilla in the mid kidney are described. This is believed to be a developmental abnormality which is associated with a pelvicalyceal pattern of two major calyces, and with renal "pseudotumour". It is important to recognize this calyceal appearance in order to distinguish it from calyceal disease.

Adult↗
PubMed1973

Excretion urography in acute renal failure.

High-dose excretion urography has been carried out in 32 patients presenting with non-obstructive acute oliguric or non-oliguric renal failure. An early, dense, persisting nephrogram has been observed in all patients with acute uncomplicated tubular necrosis and in patients with acute oliguric pyelonephritis. This appearance is modified by the presence of pre-existing renal disease. Different patterns have been observed in patients with acute glomerular disease, severe renal ischaemia, and chronic glomerular disease. The study demonstrates that careful analysis of the evolution of the nephrogram in patients with acute renal failure provides valuable information as to the nature of the parenchymal disease.

Acute Kidney Injury↗
PubMed1971

Long-term control of bacteriuria with trimethoprim-sulphonamide.

Long-term antibacterial therapy with the drug combination trimethoprim-sulphonamide has been used for the treatment of 52 patients with persistent or recurrent bacteriuria. Hypersensitivity or gastrointestinal intolerance was observed in six. Bacteriuria was controlled in 36 out of 38 patients with organisms sensitive to trimethoprim-sulphonamide, 28 having received treatment for periods ranging from 6 to 49 months. Treatment was in some cases curative and in others suppressive or prophylactic. The importance of supportive measures is re-emphasized.

Anti-Infective Agents, Urinary↗