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Biomedical subjects

I J Peled

Publications and source records attributed to I J Peled.

At least 19 recordsLinked to original sources

Nipple-areola reconstruction with a custom-made silicone ectoprosthesis.

The use of a custom-made silicone ectoprosthesis of the nipple-areola complex is presented. It is suggested, after completion of breast mound reconstruction, for those women who cannot undergo or refuse to undergo any further surgical procedure, or else for the interim until the final reconstruction is performed. It is convenient to use and the aesthetic appearance is pleasing.

Adult

V-Y plasty for perianal reconstruction after resection of tumor.

A patient with combination of perianal condylomas and Bowen's disease is described. After resection of the tumor, the defect was repaired by use of V-Y plasty using triangular island skin flaps and split thickness skin grafts. After repair and reconstruction of the perianal area, the patient regained full continence.

Aged

Reconstruction of the vulva with V-Y advanced myocutaneous gracilis flap.

Reconstruction of the vulva with V-Y advanced triangular myocutaneous gracilis flap(s) is reported. Seven patients were treated with this technique following radical vulvectomy with two minimal complications. The reliability of this known flap and the usefulness of the V-Y advancement are stressed and make it a simple and successful technique.

Female

Elevated concentrations of elements and abnormalities of neuromuscular junctions in tongue muscles of Down's syndrome.

X-ray spectrometry was used to measure the concentrations of calcium, iron, copper and zinc in tongue muscles from patients with Down's syndrome (DS) undergoing partial glossectomy. Similar measurements on samples from autopsies served as controls. Electron microscopy was used to examine neuromuscular junctions. The calcium and copper were significantly elevated and correlated in DS while the iron and zinc showed little change. The copper increase is probably connected with the known high level of Zn-Cu superoxide dismutase (SOD), coded for by chromosome 21. (In DS there is a trisomy 21). The excess of SOD may interfere with free radicals needed for excitation-contraction coupling and may be instrumental in damaging junctional membranes. The high calcium may result from such membrane damage. It is suggested that neuromuscular junction pathology, either genetic or free radical induced, may cause the tongue weakness in DS.

Adolescent