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Biomedical subjects

I J Larsen

Publications and source records attributed to I J Larsen.

9 recordsLinked to original sources

Symphalangism in Hawaii: a study of three distinct ethnic pedigrees.

Symphalangism was introduced into Hawaii by a Cherokee Indian in the late 1800s. The resultant pedigree, along with two other racially distinct pedigrees, confirms that the condition is an autosomal dominant genetic trait. Associated conditions include carpal and tarsal coalitions, cervical fusions, brachydactylism, symphalangism of the toes, and hearing loss. Surgical intervention in the hands is seldom, if ever, indicated but correction of the associated hearing loss is rewarding.

Adolescent↗

Patterns of progression in Legg-Perthes disease.

The radiographic changes in 57 patients with Legg-Perthes disease were studied to define the patterns of progression of one disease stage to the next. Femoral neck width, epiphyseal width and height, acetabular depth, "tear-drop" distance, and femoral head width and sphericity in the anteroposterior projection were measured on 529 X-ray films. Two distinct groups of hips were found. Group I (43) hips showed moderate changes in all parameters during fragmentation phase but improved in subsequent years, maintaining a concentric reduction and adequate sphericity in the femoral head. Group II (14) hips were initially identical to the hips in Group I. During midfragmentation phase, however, "tear-drop" distance increased suddenly and significant flattening and widening of the epiphysis rapidly followed. There was loss of the normal congruent relationship of acetabulum and femoral head with progressive increase in femoral head size and a marked loss of sphericity of the femoral head. Surgical reestablishment of an adequate femoral-acetabular relationship reversed the tendency toward further flattening in many cases.

Child↗

A review of supernumerary thumb and its surgical management.

Type II polydactyly is relatively easy to treat by simple ablation. Central wedge resection is an alternative treatment, providing sufficient bone and soft tissue are excised. Duplication at the MP joint may be difficult to treat because of the frequently associated problems of joint deviation and limited motion, which may produce unacceptable results. MP joint deviation in the ulnar direction of less than 30 degrees does not require treatment. Treatment may be necessary for ulnar deviation greater than 50 degrees. Metacarpal osteotomy, arthrodesis, and central wedge resection are methods of treatment. Collateral ligament reconstruction and tendon transfer were unsuccessful in one patient. IP joint deviation of greater than 15 degrees may need treatment. If there is less than 10 degrees of motion associated with it, arthrodesis is indicated when the joint is skeletally mature. When opposition is impaired thenar muscle tendon transfer is an effective treatment.

Adolescent↗