Evaluation of animal models of chronic vascular rejection.
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Animals↗
Biomedical subjects
I J Beckingham
Publications and source records attributed to I J Beckingham.
Free flap failure due to venous occlusion secondary to previous intravenous cannulation: a case report.
A case of failure of a free radial forearm flap is presented. It is surmised that this was due to venous thrombosis in the cephalic vein which showed evidence of recanalization of an old thrombus. The patient had received intravenous erythromycin some months previously.
Anastomosis, Surgical↗
Long-term follow-up of women treated with perurethral Teflon injections for stress incontinence.
The perurethral injection of Teflon has been advocated as a simple, economical and effective treatment of stress incontinence in women. We have reviewed patients treated by this technique in Nottingham. Improvement in their symptoms fell from 80% immediately after operation to 27% at follow-up 3 years later. Because of the disappointing long-term results we have abandoned this procedure for the treatment of stress incontinence.
Adult↗
A simple technique for thromboembolectomy of the upper limb.
Brachial emboli account for only 18% of arterial emboli and present as an uncommon emergency to surgeons. We have examined the route taken and probable outcome of arterial embolectomy of the upper limb in 31 cadaveric limbs using standard and Coude tipped embolectomy catheters. Using a standard embolectomy catheter, the larger of the two upper limb arteries was cannulated in only 42% of our series. However, using a 30 degree Coude tipped catheter, both radial and ulnar arteries could be cannulated in 87% of limbs, ensuring a more complete embolectomy without the need formally to expose the brachial artery bifurcation.
Aged↗
Acute thrombocytopenia after De-Nol.
We describe a case of severe acute thrombocytopenia in a 72 year old man treated with De-Nol for erosive biliary gastritis.
Acute Disease↗
Islet blood flow following insulin administration.
Blood flow to the pancreatic islets of the anaesthetised rat was measured using the microsphere method. Basal flow was 29 (+/- 6) microliter/min per pancreas which was equivalent to 2.1 (+/- 0.2)% of the total pancreatic flow. The intravenous administration of 4 IU of soluble insulin, which rendered the animals hypoglycaemic, selectively increased islet flow to 93 (+/- 19) microliter/min per pancreas, equivalent to 5.4 (+/- 0.2)% of total pancreatic flow. It is suggested that this may be related to an enhanced release of glucagon from the islet A cells in response to the hypoglycaemia. Administration of 2.5 ml of a 25% glucose solution intraperitoneally gave rise to hyperglycaemia and produced a similar preferential increase in islet blood flow to 86 (+/- 25) microliter/min per pancreas, 7.4 (+/- 0.2)% of total pancreatic flow.
Animals↗
Brunner's gland hyperplasia at the ampulla of Vater.
Brunner's gland hyperplasia (BGH) is a diagnostic challenge where in the pathophysiology and natural history remain poorly understood. This Case Report describes BGH arising at the ampulla of Vater, causing abdominal pain and vomiting in a 46-year-old man. Owing to the inconclusive nature of imaging studies and suspicious intraoperative findings, a Whipple resection was performed without any complications. Histological analysis showed that the obstructing lesion was BGH, with no evidence of malignancy. This is only the second such case of its kind at the ampulla of Vater to be reported. In addition, we present the previously unreported endoscopic ultrasound findings. The subsequent literature review focuses on the pathophysiology, clinical presentation, diagnosis and management of BGH.
Ampulla of Vater↗