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Biomedical subjects

I Iwasaki

Publications and source records attributed to I Iwasaki.

At least 37 records · Page 2Linked to original sources
PubMed1985

Benign hemangioendothelioma of the pancreas with obstructive jaundice.

A 3-year-old boy with benign hemangioendothelioma of the pancreas is reported. He showed the presenting sign of obstructive jaundice. The boy was treated with temporary choledochojejunal bypass without additional treatment. In a 16-month follow-up the child has been well and asymptomatic. Laboratory data showed no abnormality. Biopsied specimen of pancreatic head showed hemangiomatous pattern histologically. Immunohistochemical studies of the biopsy revealed positive reaction to factor VIII-related antigen (FVIII-RAG), and endothelial cell marker, supporting an endothelial origin. Hemangioendothelioma has a favorable prognosis and spontaneous regression can be expected. So the first treatment of the tumor should be conservative.

Child, Preschool↗
PubMed1985

A cystic adenomatoid tumor of the uterus simulating lymphangioma grossly.

We are reporting a rare case of an adenomatoid tumor of the uterus having multicystic gross appearance. A 32-year-old woman complaining of dysmenorrhea had multicystic mass lesions on the posterior wall of the right cornual region of the uterus. The specimen showed a honeycomb appearance with mucoid content. Microscopically, numerous gland-like spaces lined with low cuboidal cells were observed beneath the serosa, and mucopolysaccharide material accumulated in the cystic spaces forming, honeycomb-like lesions surrounded by myometrial tissue. The postoperative course was uneventful and the patient was discharged on the 9th day after the operation. "Cystic adenomatoid tumor of the uterus" was diagnosed. The patient is being followed up continuously, so far without recurrence.

Adenoma↗
PubMed1985

Proliferative Brenner tumor of the ovary.

A 72-year-old woman was admitted with abdominal distention and a hard mass in the pelvis. Abdominal laparotomy was performed, and a large solid left ovarian tumor was found. Left salpingo-oophorectomy was carried out. Histology showed cords and nests of stratified high cellular epithelium with dense eosinophilic material in epithelial nests and dense fibrous stroma identified as a Brenner tumor of the ovary. Because mild to moderate cytologic atypia with mitotic activity was present, a diagnosis of proliferative Brenner tumor was made. After the operation, the patient was in good condition with no recurrence or metastasis so far.

Aged↗
PubMed1985

Niemann-Pick disease associated with liver disorders.

We report a case of Niemann-Pick disease (NPD) with accumulation of sphingomyelin in reticuloendothelial system (RES), hepatocellular giant cell transformation (GCT), cirrhosis, and multiple hepatocellular adenomata in a 19-month-old girl. GCT, but no NP-cells, were seen at age 3 months by biopsy. Cirrhosis and hepatocellular adenomata were demonstrated in the liver at 19 months of age. Cytoplasmic, probably locally synthesized, globules of alpha-1-antitrypsin (A-1-AT) were accumulated in the hepatocellular adenomata. A-1-AT and alpha-fetoprotein (AFP) were present in the serum.

Fatty Liver↗
PubMed1985

Promoting effects of bile acid to intestinal tumorigenesis in gnotobiotic ICR mice.

Gnotobiotes were produced by administrating Lactobacillus plantarum IAM 1041 in ICR strain male germfree mice which were fed by ordinary or high fat diet. Both groups were orally administered 0.3 mg/10 g of body weight (B.W.) of methylazoxymethanol (MAM) acetate. The oral administration of 0.3 mg/10 g/B.W. once a week for 11 consecutive weeks caused a total of 68 adenomatous polyps in the large intestine (an average of 11.4/mouse) of gnotobiotic high fat diet mice and a total of 32 adenomatous polyps (an average of 5.3/mouse) of the ordinary diet mice. There were no malignancies in either of the groups. Bile acids in the feces showed higher values in the high fat diet group than in the ordinary group. Bile acids are a factor which promotes the appearance of intestinal tumors. It was also assumed that the L. plantarum promoted the activation of beta-glucuronidase and alcohol dehydrogenase in the liver and intestine.

Alcohol Dehydrogenase↗
PubMed1985

Effects of minute amounts of cigarette smoke with or without nebulized N-nitroso-N-methylurethane on the respiratory tract of mice.

The effects of minute amounts of cigarette smoke with or without nebulized N-nitroso-N-methylurethane (NMUT) on the respiratory epithelia of mice were examined. The first group received the combination of NMUT nebulization and cigarette smoke inhalation, the second group NMUT nebulization only, the third group cigarette smoke inhalation only and the fourth group no treatment. The first group showed squamous cell carcinomas in the nasal cavity (4 out of 10 mice), trachea (4 out of 10 mice) and lung (2 out of 10 mice). In the second group squamous cell carcinomas with keratosis were found in the nasal cavity (2 out of 10 mice) and in the lung (1 out of 10 mice). Furthermore, basal cell hyperplasias, squamous metaplasias and dysplastic changes were found in these two groups. The third group showed basal cell hyperplasias and squamous metaplasias in the nasal cavity and hypertrophy of Clara cells. No marked changes of epithelia of the respiratory tract in the fourth group were seen. Adenomas and adenocarcinomas were not found in any group. Statistically, there is a significant difference in the incidence of dysplastic change of the trachea between group 1 and group 2 (P less than 0.05). These results suggest that minute amounts of cigarette smoke, in combination with carcinogens, may have cocarcinogenic action and that squamous cell carcinoma may pass through the course of basal cell hyperplasia, squamous metaplasia and dysplastic change of the epithelia.

Aerosols↗
PubMed1984

[A statistical approach to measure fitness by PWC170].

This paper discusses measurements of physical work capacity. When the sample size is small, its model selection problem is difficult in the multiple regression analysis. Although the development of model selection may be correct, it is not always useful for practical data. Since the number of the parameters is large compared with the sample size, we shall discretize continuous data into categorical data and shall use the CATDAP program.

Computers↗
PubMed1984

Osteogenesis bioassay and immunohistochemical and radioisotopic studies of parotin, parotid gland extract, and subunit.

Bioassay data support the hypothesis that the salivary gland participates in endocrine regulation of the development and maintenance of connective tissues. Epiphyseal cartilages become dystrophic in young growing rats after the resection of all major salivary glands. A subunit obtained from parotin, an extract of bovine parotid glands, contains the active agent for the presumed endocrine function of the salivary gland. Daily injections of 3 mg/rat of parotin or the subunit allow normal epiphyseal endochondral osteogenesis in salivary gland-deprived rats. The active agent appears to be secreted by the salivary acinar cells and resorbed through the striated ducts. Pancreatic islets and striated ducts of salivary glands share immunohistochemical activities for insulin, glucagon, and the subunit of parotin. Hyperglycemia and hypocholesterolemia occur in intact rats given 5 mg/day of parotin for 30 days. Together these data suggest endocrine functions of the salivary gland and possible interactions between the pancreatic islet and salivary gland.

Animals↗
PubMed1984

Primary ovarian pregnancy in a cystic teratoma.

Hemoperitoneum was identified by culdocentesis in a 26-year-old woman suffering acute abdominal pain. A pregnancy test was positive. Operation indicated a ruptured ovarian pregnancy, and histologic examination revealed primary intrafollicular ovarian pregnancy in a cystic teratoma. Ovarian pregnancy in an ovarian tumor is exceedingly rare.

Adult↗
PubMed1984

Leiomyosarcoma of pulmonary truncus.

Insidious and progressive right heart failure of obscure origin warrants differential diagnosis of primary sarcoma of the pulmonary artery in patients of both sexes and 20 years of age and older. We report a case of primary leiomyosarcoma of the pulmonary truncus in a 67 years old woman. She had been well in general until when she started having fluctuating and progressive right heart failure three years ago. Clinical data included systolic murmurs in the pulmonary valve area, right ventricular hypertrophy, diminished x-ray density of the pulmonary vasculature, moderate elevation of serum LDH, alkaline phosphatase, and uric acid, and prolonged or unobtainable circulation time from the arm to lungs. The immediate cause of death was attributable to right heart failure due to pulmonary arterial stenosis caused by a locally invasive leiomyosarcoma apparently arising in the pulmonary truncus. Contributing to this right heart failure were 280 ml of serosanguinous pericardial effusion and fibrinous pericarditis.

Aged↗
PubMed1984

Suppressive effect of cupric acetate on DNA alkylation, DNA synthesis and tumorigenesis in the liver of dimethylnitrosamine-treated rats.

The effect of cupric acetate on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in rats was investigated. The surviving rats in the group given DMN (25 ppm) in the drinking water alone were killed at 26 weeks and it was found that 12 of 16 rats had developed liver tumors. In the group given DMN and cupric acetate (sc injections of 2 mg of Cu/kg of body weight once a week for 26 weeks), 7 of 22 rats developed liver tumors. The incidence of liver tumors in rats given DMN and cupric acetate was thus only about 40% of that in rats given DMN alone. No tumor was observed in the group given saline or cupric acetate alone. The thymidine incorporation into the liver DNA of rats was measured at 2 and 4 weeks after the start of the carcinogenicity experiment. The thymidine incorporation into the liver DNA of rats given DMN was significantly suppressed by the administration of cupric acetate. The methylation of liver DNA in rats given a single dose of DMN was also significantly suppressed by sc injection of cupric acetate; the formation of both O6-methylguanine and 7-methylguanine was reduced. This result suggests that sc injection of cupric acetate may have a suppressive effect on the initiation of carcinogenesis in the liver.

Alkylation↗
PubMed1984

Aneurysm of the intrahepatic branch of the portal vein. Report of two cases.

Two patients in whom real-time ultrasonography and percutaneous transhepatic portography or the venous phase of the arteriogram of the superior mesenteric artery demonstrated a localized saccular dilation of a peripheral branch of the portal vein are described. One patient subsequently died, and autopsy confirmed the diagnosis. A hypoechoic lesion continuous with a branch of the portal vein seems to be the characteristic sonographic picture. Radiologic evidence for portal vein aneurysm was obtained in only 2 of 300 patients with portal hypertension in whom percutaneous transhepatic portography was performed, and in 2 of 3000 patients who visited our unit and in whom ultrasonography for the liver was performed. Thus, aneurysm of the intrahepatic portal vein does occur, but very rarely.

Aneurysm↗
PubMed1984

Renal tubular disturbances induced by tributyl-tin oxide in guinea pigs: a secondary Fanconi syndrome.

Painting of tributyl-tin oxide on the skin induced a secondary Fanconi syndrome in guinea pigs. In the urine of these animals, excretion of sodium, chloride, phosphate, glucose and many kinds of amino acids increased and reached a maximum between day 40 and 50. In sera, the concentrations of phosphate and certain amino acids were low due to excessive loss into urine. Histological examination of the kidney revealed damage to the tubular epithelium with no glomerular change. It was also found that cytochrome P-450 in the kidney and 1-25-dihydroxy vitamin D in serum were reduced in the tin-treated animals. It is most likely that tributyl-tin oxide caused a secondary Fanconi syndrome as defined by renal tubular disturbances represented by glucosuria, generalized amino aciduria, phosphaturia, and hypophosphatemia.

Administration, Topical↗
PubMed1983

Osteogenesis bioassay and immunohistochemical and radioisotopic studies of a subunit of parotin, a parotid gland extract.

Bioassay data support the hypothesis that salivary glands participate in endocrine regulation of the development and maintenance of connective tissues. Resection of all three major salivary glands damages epiphyseal cartilages in young growing rats. A subunit obtained from parotin, an extract of bovine parotid glands, contains the active agent for the presumed endocrine function of salivary glands. Daily injections of 3 mg/rat of parotin or the subunit allow normal epiphyseal endochondral osteogenesis in salivary gland-deprived rats. The active agent appears to be secreted by the salivary acinar cells and resorbed through the striated ducts. Pancreatic islets and striated ducts of salivary glands share immunohistochemical activities for insulin, glucagon, and the subunit of parotin. Hyperglycemia and hypocholesterolemia occurred in intact rats given 1 to 5 mg/day of parotin for 30 days. These data together suggest endocrine function of the salivary glands and possible interactions between the pancreatic islets and salivary glands.

Animals↗
PubMed1983

Potentiation of large intestinal tumorigenicity of cycasin derivative by high-fat diet and Lactobacillus in germfree mice.

Large intestinal tumorigenesis was investigated in germ free (GF) mice following the administration of methylazoxymethanol (MAM) acetate, lard, and Lactobacillus arabinosus. Twelve weekly doses of 0.3 mg/10 g MAM acetate given to groups of male weanling, germfree ICR mice, fed either low-fat (LF) chow alone, or chow with added lard (HF). Additional groups of mice, on the low-fat diet, were monocontaminated with Lactobacillus arabinosus (GA) and they and their GF controls were given 12 weekly doses of 0.2 mg/10 g of MAM acetate. The HF and LF groups were sacrificed after 123 days, and the GA and GF groups after 214 days. Serial sections of the entire large intestine of the MAM acetate-treated mice revealed many more sessile polyps in the mice maintained on the high-fat diet. In the mice monocontaminated with Lactobacillus, numerous tumors were found, of which 25 percent were invasive. In addition, the polyps found in these animals were generally considerably larger than the polyps found in the GF mice. Atypia occurred in the large intestinal mucosa in all groups. Lard enhanced the large intestinal polypogenesis induced by MAM acetate in germfree mice. Gnotobiosis potentiated the formation of sessile polyps, and carcinogenesis.

Animals↗