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Biomedical subjects

I Iu Adamova

Publications and source records attributed to I Iu Adamova.

11 recordsLinked to original sources
PubMed2004

[Ethnic differences in apolipoprotein B levels in hyperlipidemia in Russian and Kirghiz populations].

AIM: To evaluate the levels of apolipoprotein B (apo-B) and coronary heart disease (CHD) risk factors in Russians and the Kirghiz with primary hyperlipidemia (PHL). MATERIAL AND METHODS: Lipid spectrum of the blood (LDLP and HDLP cholesterol, total cholesterol, triglycerides), apo-B, CHD risk factors were studied in 60 Russian and 75 Kirghis patients with PHL aged 28 to 67 years (mean age 50.0 +/- 7.59 years, 56 females and 79 males). RESULTS: In Russians a mean level of LDLP cholesterol and apo-B was significantly higher than in Kirghiz patients (3.95 +/- 1.29 mmol/l vs 3.51 +/- 1.17 mmol/l, p = 0.042; 173.3 +/- 57.3 mg/dl vs 145.5 +/- 49.3 mg/dl, p = 0.003, respectively). CHD in both ethnic groups occurred with similar rates. The multifactorial regression analysis shows that an apo-B concentration can serve an independent risk factor associated with CHD in the Kirghiz population (beta = 0.25, p = 0.03) while in Russians living in Kirghizia this factor is a low content of HDLP cholesterol (beta = -0.25, p = 0.05).

Adult↗
PubMed2002

[Apheresis of immunoglobulins - new approach to the treatment of severe dilated cardiomyopathy].

Two courses of immunoadsorption with 'Ig Adsopak' were used in the treatment of a patient with dilated cardiomyopathy (DCM) during which all class G and partially class M and A immunoglobulins were removed. Every course consisted of 5 daily procedures and resulted in removal of 98% of immunoglobulins. This was associated with complete removal of autoantibodies to beta1-adrenoreceptor. After the end of a course loss of immunoglobulins was replenished by intravenous infusion of Pentaglobin and Oktagam. Echocardiographic study carried out before, during and after second course of apheresis revealed reduction of left and right ventricular and atrial volumes and dimensions, improvement of contractility of anterior part of interventricular septum and of anterolateral left ventricular wall. As efficacy of drug therapy of dilated cardiomyopathy is low and facilities of cardiac transplantation are limited the method of therapeutic apheresis reveals novel perspectives of the treatment of dilated cardiomyopathies.

Blood Component Removal↗
PubMed1993

[Atherosclerosis of the major arteries of the head and the content of lipoprotein(a) in the blood plasma].

It is established that atherosclerotic patients with impaired major arteries of the head have high concentration of blood lipoprotein (a) following ischemic disorder of cerebral circulation. Irrespectively of the clinical picture, atherosclerosis of the major head arteries correlated in severity with blood levels of lipoprotein (a). It is suggested that lipoprotein (a) can serve an essential biochemical marker of major head arteries atherosclerosis.

Acute Disease↗
PubMed1992

[Use of immunosorption for selective decrease of lipoprotein (A) levels in patients with coronary atherosclerosis].

Lipoprotein (a) [L(a)] is an atherogenic lipoprotein, its human plasma concentration correlates with the occurrence of coronary heart disease. The procedure for selectively removing L(a) with an anti-L(a) immunosorbent was performed to treat 3 patients who had high L(a), normal total cholesterol and other lipoprotein levels. All the patients had coronary stenosis as documented by angiography. After L(a)-apheresis, the level of L(a) decreased by 72%, while that of other plasma components, including low density lipoproteins virtually unchanged. Thus, the procedure of L(a)-apheresis is an effective and safe method for lowering human blood L(a) concentrations. In addition, this in vivo model allows information on L(a) metabolism to be obtained.

Adult↗
PubMed1992

[A comparison of 3 methods of lipoprotein (a) isolation from human plasma].

Three methods for purification of lipoprotein (a) [Lp(a)] from human plasma were compared. Method I: two-stage ultracentrifugation with subsequent gel-filtration of Lp(a) containing fractions (1.063-1.090 g/ml) on Sepharose CL-4B. Method II: ultracentrifugation followed by affinity chromatography of plasma fraction (1.063 g/ml) on anti-apoB sorbent. Method III: affinity chromatography of the whole plasma on anti-apo(a) sorbent. The Lp(a) yield of these methods is 35, 54 and 41%, respectively. The method III is preferable of these three because it permitted high purification of a large amount of Lp(a) by single-step chromatography.

Chromatography, Affinity↗
PubMed1987

[Interaction of gangliosides with low-density proteins from human blood].

Gangliosides have been shown to modulate the receptor-mediated endocytosis of low density lipoproteins (LDL). The direct interaction of LDL with various gangliosides has been studied. Binding of gangliosides to LDL immobilized on CNBr-Sepharose (LDL-Sepharose) and the influence of gangliosides on the fluorescence of LDL containing anthrylvinyl-labeled sphingomyelin were investigated. The binding of 3H-gangliosides to LDL-Sepharose, as well as fluorescence polarization of LDL were found to depend on the structure and concentration of the gangliosides in a specific saturable manner. The data obtained indicate that gangliosides interact with apolipoprotein B via specific binding sites.

Fluorescence Polarization↗
PubMed1986

[Theoretical and experimental substantiation of immunosorption procedures].

The authors introduce a new approach in a clinical and experimental research termed immunosorption. They have developed highly specific and selective agarose-conjugated immunosorbent with monospecific goat antibodies against human LDL. The sorbent is used in clinical practice for removal of atherogenic lipoproteins from the patients plasma--LDL apheresis procedure. The advantages of affinity chromatography based on LDL-apheresis over plasma-pheresis and haemosorption are discussed. Nonspecific adsorptive, hydrophobic and electrostatic interactions that take place during haemosorption do not provide the required selectivity, while immunosorption procedure enables minimization of nonspecific adsorption of plasma compounds during LDL-apheresis. Several examples illustrate clinical applications of immunosorption method.

Animals↗