Biomedical subjects

I Ilić

Publications and source records attributed to I Ilić.

2 recordsLinked to original sources

PubMed1992

Entropies of coding and noncoding sequences of DNA and proteins.

The entropies of protein coding genes from Escherichia coli were calculated according to Boltzmann's formula. Entropies of the coding regions were compared to the entropies of noncoding or miscoding ones. With nucleotides as code units, the entropies of the coding regions, when compared to the entropies of complete sequences (leader and coding region as well as trailer), were seen to be lower but with a marginal statistical significance. With triplets of nucleotides as code units, the entropies of correct reading frames were significantly lower than the entropies of frameshifts +1 and -1. With amino acids as code units, the results were opposite: Biologically functional proteins had significantly higher entropies than proteins translated from the frameshifted sequences. We attempt to explain this paradox with the hypothesis that the genetic code may have the ability of lowering information content (increasing entropy) of proteins while translating them from DNA. This ability might be beneficial to bacteria because it would make the functional proteins more probable (having a higher entropy) than nonfunctional proteins translated from frameshifted sequences.

Amino Acids↗

PubMed1977

[Renal echinococcus].

Incidence of renal hydatid cyst is rare and its diagnosis should be made with the utmost care and after subjecting the patient to intensive investigations to exclude other pathologies. Because of the rarity of the disease and because of the clinical similarity with other surgical lesions affecting the kidney, mainly renal tumours and simple renal cysts, the authors are encouraged to record thirty-nine cases of renal hydatid cysts. The value of investigations as aids in the diagnosis has been discussed. The direct consequence of uncertain diagnosis is the risk of performing unwarranted ablative surgery, whereas conservative treatment is currently advocated by the majority of investigators. We followed the policy of saving as much renal tissue in each case, and we obtained results that encourage us to believe that nephrectomy for renal hydatidosis can be avoided in a great many cases with complete therapeutic success. With the exception of cystectomy and marsupialisation--which is recommended as a lifesaving procedure, the method of our choice consisted of a partial pericystectomy, i.e. resection of the pericystium exteriorized until it was flush with the renal parenchyma.

Echinococcosis↗