Biomedical subjects

I I Zatevakhin

Publications and source records attributed to I I Zatevakhin.

At least 19 recordsLinked to original sources

PubMed2005

[The role of the immune system in the pathogenesis of atherosclerosis].

This paper is concerned with intracellular infections such as herpes virus, cytomegalovirus and Chlamydia pneumonia which may be implicated in the pathogenesis of atherosclerosis. These viral and bacterial pathogens are regarded as potential causative factors in the pathogenesis of atherosclerosis. The authors support the hypothesis that these infections may induce endothelial injury. The paper reviews both direct and indirect immune system-mediated effect of the viruses indicated on the disease process and the potential role of killer cells in endothelial injury.

Arteriosclerosis↗

PubMed2005

[Choice of the extent and the terms of sanifying procedures after vascular reconstructive surgeries in patients with stage IV chronic arterial lower limb insufficiency].

Results of vascular reconstructions with the following sanifying procedures performed in 82 patients with stage IV chronic arterial lower limb insufficiency are analyzed. Based on complex evaluation of microcirculation three types of tissues ischemic lesion are revealed: irreversible, severe and mild. Patients with irreversible lesion of the tissues of a distal part of the lower extremity require vascular reconstruction with simultaneous amputation at the upper third of the shank. In a severe reversible ischemic lesion of the tissues radical sanifying surgery with preservation of limb support function is better to perform not earlier than one month after vascular reconstruction. Mild ischemia of tissues permits performing minimal sanifying procedure with primary closure of the wound simultaneously with vascular surgery.

Chronic Disease↗

PubMed2003

[On the etiology of abdominal aortic aneurysms: current state of the problem].

The paper reviews the last publications on the etiology and pathogenesis of abdominal aortic aneurysms (AAA), analyses different risk factors and possible pathological mechanisms related to the process of aortic aneurysmal dilatation. The authors conclude that AAA results from the combination of different factors whose special impact can vary in every case.

Aged↗

PubMed1991

[Selection of surgical tactics in infected vascular transplants].

The article analyzes a 10-years experience of the clinic work with choice of surgical tactics in infecting vascular transplants after reconstructive operations on the aorta and arteries of lower extremities in 57 of 1079 patients operated upon. The active-waiting tactics using conservative antibacterial methods of treatment was unsuccessful since in 89.7% of cases it resulted in the development of erosive bleedings and in 62.8%--in lethal issues. Preventive reoperations (atypical shunting included) before the development of erosive bleeding in infected vascular transplants reduced the frequency of amputations from 46.2% to 26.6% (in the discharged patients), and reduced lethality almost 4 times (from 62.8% to 16.7%).

Amputation, Surgical↗

PubMed1990

[The procedure for treating patients with a late thrombosis of the vascular prostheses or of the reconstructed arteries of the pelvis and lower extremities].

Results of the investigation of clinical observations of 235 patients with late thrombosis of vascular prostheses or reconstructed arteries of the pelvis and lower extremities enabled the authors to develop a medical tactics based on the active surgery method aimed at the reestablishment of the disturbed blood flow. The time of reconstructive reoperations depends on the clinical course of recurrent ischemia. The conservative treatment, as less effective, is indicated to some patients with not severe ischemia and without local or general conditions for operations. The authors believe that differentiated medical approach will allow improvement of results of treatment of patients with this severe disease.

Arteries↗

PubMed1990

[Cryodestruction of the pancreas in the surgical treatment of extensive hemorrhagic pancreatic necrosis].

Resulting from the experimental investigations on 70 dogs and analysis of 3 clinical cases, the authors have established that cryodestruction of the pancreas in extensive hemorrhagic pancreonecrosis permitted to cup off promptly the enzymatic toxemia and prevented the development of secondary purulent complications. The most pronounced anti-enzyme effect was noted in combination of the corpus-caudal resection of the pancreas and cryodestruction of the organ remainder.

Animals↗

PubMed1990

[Surgical tactics in peptic ulcer hemorrhage].

The article discusses the results of treatment of 256 patients with gastroduodenal hemorrhages. The routine actively temporizing strategy was employed in the treatment of the first group of patients. The total mortality in the group was 13%, postoperative one, 33%. In the second group active surgical strategy was based on the results of recurrent hemorrhage prognosis. The total mortality was 6%, postoperative one, 6.5%. It is concluded that active surgical strategy which is based on prediction of recurrent hemorrhage yields better results of management of patients with ulcerative hemorrhages.

Adult↗

PubMed1990

[Endolymphatic antibiotic therapy in the prevention and treatment of purulent-septic complications in vascular surgery].

With the aim of prophylaxis and treatment of purulent-septic complications, in 12 patients with IV stage chronic arterial insufficiency (group 1) before the operation, the direct endolymphatic antibioticotherapy (ELAT) was performed, in 13 patients with IIB-III stage of the disease (group 2) after the operation with the aim of treating purulent septic complications. The control group consisted of 10 patients with IV stage chronic arterial insufficiency. In group 1 patients, after the operation, there were no inflammatory changes in the wound, the wound healed by primary intention. In 7 control patients, the suppuration of inguinal wounds was noted. In group 2 patients, against the ELAT background, the regress of inflammation, reduction of the degree of bacterial contamination of the wounds, their cleaning and healing by secondary intention were noted.

Anti-Bacterial Agents↗

PubMed1989

[Hemodynamic aspects of the treatment of patients with "critical ischemia" of the lower extremities].

A complex examination of 60 patients with different stages of disturbances of blood circulation (by the Fontain classification) with chronic arterial insufficiency was performed. Specific features of regional hemodynamics were revealed in patient with "critical ischemia" (3rd and 4th stages of the disease). Threshold values of the "critical ischemia" were determined, most informative of them being the malleolus index and oxygen pressure on the foot. An analysis of results of the investigation in the dynamics of the treatment performed has shown possible effectiveness of restorative operations in treatment of patients with severe stages of chronic arterial insufficiency.

Arterial Occlusive Diseases↗

PubMed1989

[Recurrence of ischemia of the lower limbs in patients with functioning vascular prosthesis].

On the basis of experience in surgical treatment of 242 patients with recurrent ischemia of the lower limbs in late periods after operations on the aorta and peripheral arteries, the authors singled out a group of patients (44) with unobstructed but hemodynamically incompetent vascular prostheses. Their hemodynamic changes were caused by stenosis of the vascular anastomoses and shunts or by the development of occlusions of arteries beyond the reconstructed segments. The authors relate all these complications to the prethrombotic stage of late reocclusions and insist in their recognition before the development of thrombosis of the vascular prosthesis. The important role of dynamic Doppler flowmetry in early diagnosis is shown. Reoperations for correction of the blood flow were conducted on 40 patients. The results were good in 92.5% of them. The authors recommend wider use of preventive operations which contribute to the improvement of surgical treatment of patients with late reocclusions of arteries and vascular prostheses.

Blood Vessel Prosthesis↗

PubMed1989

[Doppler sphygmomanometry in the diagnosis of obliterating atherosclerosis].

The diagnostic possibilities of regional systolic pressure measurement was appraised in examination of 76 patients with various localization of the occlusive lesion and stages of the disease. The indices of regional systolic pressure (IRSP) were compared for precise comparative analysis. The indices of changes of systolic pressure (ICP) between the measurement zones were calculated for comparison of pressure changes along the length of certain limb segments. The malleolar systolic pressure index is of highest diagnostic importance in identifying the occlusive lesion, whatever its type. IRSP changes at different levels give a precise idea of the hemodynamic conditions of each type of occlusive lesion. The ICP should be accepted as the criterion of the spread of the occlusive process in arteries below the inguinal ligament. The suggested method makes it possible not only to detect the occlusive process, but to differentiate an aorto-iliac and femoropopliteal blockade or their combination.

Arteriosclerosis Obliterans↗

PubMed1988

[Experimental validation of a method for the early diagnosis of the infection of vascular prostheses using 99m-TC-labelled leukocytes].

Experiments on 9 dogs were staged for a study of a method of early diagnosis of infectivity of vascular prostheses of the abdominal aorta with the help of 99m-Tc-labelled leukocytes. A sterile synthetic vascular prosthesis was used for prosthetics of the abdominal aorta in the 1st control group of animals, a prosthesis, previously infected with St. aureus, was used in the 2nd group, a sterile prosthesis with its subsequent infecting by i.v. injection of St. aureus was used in the 3rd group. The role of antibiotic therapy in infectivity of vascular prostheses was studied on the animals of the 3rd group. A radionuclide study with autologous 99m-Tc-labelled leukocytes was conducted using the Deina-2 camera (Picker). Visualization of the prostheses was unobserved in the 1st control group; in the 2nd group the accumulation of 99m-Tc-leukocytes in the zone of the prosthesis and its visualization on the 4th-5th min. were noted; in the 3rd group the prosthesis was visualized on the 10th-15th min. After antibiotic therapy in the 3rd group visualization of the prosthesis was undetectable. The proposed method permitted visualization of a zone of infection in the early postoperative period, observation of the time course of infection development, and assessment of the efficacy of antibiotic therapy.

Animals↗

PubMed1988

[Obturator shunting in suppuration of vascular prostheses].

An experience with using obturatory shunts in 10 patients with suppurations of vascular prostheses after reconstructive operations on the aorto-iliac segment for its occlusive lesion is presented. The authors have come to a conclusion that extra-anatomical shunting through the closing inlet of the pelvis when combined with resection or removal of the infected vascular prosthesis, local and general antibacterial therapy is an effective method of treatment of the pathology in question. The modified method of shunting facilitates performing the operation in most critical patients. Good results were obtained in 7 of 10 patients operated upon. Two patients died. The amputation of the extremity was fulfilled in 1 patient.

Adolescent↗

PubMed1987