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Biomedical subjects

I I Berishvili

Publications and source records attributed to I I Berishvili.

At least 19 recordsLinked to original sources
PubMed2005

Use of human VEGF(165) gene for therapeutic angiogenesis in coronary patients: first results.

The paper presents the first results of therapeutic angiogenesis in clinical cardiosurgery: human VEGF(165) gene transplantation to coronary patients. The use of this therapeutic method is particularly effective in patients with inoperable cardiovascular injuries, i.e. patients with the most severe condition, in whom treatment remains little effective at the modern level of cardiosurgery development.

Animals↗
PubMed2005

[Transmyocardial laser revascularization of the myocardium].

The paper presents the results of a 5-year follow-up after coronary artery bypass grafting (CABG) combined with transmyocardial laser revascularization (TMLR). The study revealed high efficiency and safety of the combined surgery in patients with coronary heart disease (CHD) associated with diffuse lesions of coronary arteries. The procedure improved the myocardial perfusion and contractile function, thus significantly increasing the patients' life quality. Combined CABG + TMLR noticeably improved stenocardia functional class, increased physical exercise tolerance and led to a significant reduction in nitrate agent consumption in patients with CHD.

Angioplasty, Balloon, Coronary↗
PubMed2005

[ECG-gated single-photon emission computed tomography with 99mTC-tetraphosmin in diagnostics of short-term myocardium stunning under the condition of stress-induced ischemia in CHD patients with multivascular lesions of coronary vessels].

The authors analyzed the efficiency of ECG-gated single-photon emission computed tomography (SPECT) with 99mTc-tetraphosmin in diagnostics of short-term myocardium stunning in CAD patients with transient ischemia. The technique was applied to 16 CAD patients. Combined evaluation of perfusion was based on the analysis of radiotracer uptake level in left ventricle (LV) myocardium. In order to evaluate myocardium function the authors measured LV systolic thickening index, using 20-segment pattern. 8 out of 16 patients (50%) displayed the phenomenon of stress-induced stunning. The volume of stunned myocardium in individual patients was 2 to 7 LV segments. In general, up to 37% (29/78) of reversible perfusion defects are subjected to short-term stunning under the condition of transient ischemia. After surgical treatment, 84% of segments with signs of stunning normalized their functioning both under stress and at rest.

Coronary Disease↗
PubMed2003

Results of hospital bypass angiography in patients with coronary artery disease undergoing arterial and vein myocardial revascularization.

This paper analyzes the results of 94 coronary artery bypass grafts accomplished at the Department of Surgical Treatment of Concomitant Lesions of Coronary and Peripheral Arteries, A.N. Bakulev SCCVS, RAMS, in patients with coronary artery disease (CAD) provided control hospital bypass angiography over the period 1998 to 2002. Control bypass angiography revealed thrombosis of 11.7% of vein and of 1.5% of arterial grafts. The main causes of vein graft thromboses were: bypass grafting of small coronary arteries, that of the coronary arteries with so-called 'immature' stenoses, and mediastinitis. The data presented herein evidence that hospital arterial bypass graft provides for a considerably higher percentage of competence versus vein bypass graft. Hospital bypass angiography is essentially safe while its findings allow to make a detailed analysis of complications whereby upgrading the efficacy of operations.

Arteries↗
PubMed2001

[Surgical treatment of ischemic heart disease by transmyocardial laser revascularization].

Results of transmyocardial laser revascularisation (TMLR) of the myocardium are analyzed. Two types of laser equipment were used domestic laser high-energy CO2 synchronized with patient's ECG, and XeCl laser Max-20. 32 patients underwent TMLR as a single method of surgical correction of the disease, 15 in combination with other methods of myocardium revascularisation. Obtained data testify that TMLR is a highly effective procedure in selective patients with IHD. Results confirm necessity of differential surgical policy for ischemic heart disease that permits to use adequate method of myocardium revascularisation for each patient.

Electrocardiography↗
PubMed2001

[Treatment of ischemic heart disease by minimally invasive coronary surgery with the "Octopus" system].

Results of 30 operations performed for combined lesions of coronary and peripheral arteries are analyzed. All the operations were performed as off-pump minimally invasive coronary surgery (MICS) on beating heart with "Octopus" system Medtromic. There were no lethal outcomes. Number of complications was minimal. MICS is high-effective procedure in selected patients with coronary heart disease. It is necessary to use differential policy of surgical treatment of coronary heart disease.

Angioplasty, Balloon, Coronary↗
PubMed1992

[Origin of the aorta and pulmonary artery from the right ventricle: anatomic and echocardiographic comparisons].

The origin of the aorta and pulmonary artery from the right ventricle is a complicated and little studied congenital cardiac malformation. The A. N. Bakulev Institute of Cardiovascular Surgery, USSR Academy of Medical Sciences, have developed anatomic and morphological criteria for the malformation. With the criteria, echocardiograms from 64 patients were retrospectively analysed and their anatomic and echocardiographic comparisons were made. The findings revealed the echocardiographic measures of the aorta and pulmonary artery from the right ventricle and determines the optimal echocardiographic projections for their estimate.

Adolescent↗
PubMed1991

[Classification of ventricular septal defects].

The hearts were examined from 125 patients with isolated ventricular septal defects (VSD) who had died at the age of 0-14 years before or without operation. One hundred twenty five heart showed 178 defects: 103 with isolated, 22 with multiple VSD. Five major defect types were identified: (1) perimembranous; (2) sinus; (3) central trabecular; (4) boundary muscular trabecular; (5) infundibular. According to the relevance of fibrous skeleton and cardiac conduction system, the defects of various sites are divided into 2 large groups: 1) unadjacent to them (muscular) and 2) adjacent. In terms of septal geometry, there are also two large groups: 1) those located in the inflow portion of the septum and 2) those located in the outflow portion.

Adolescent↗
PubMed1991

[Surgical anatomy of subaortic conus of the normal heart].

One hundred and fourty-three normal hearts have been studied. The conoid septum, supraventricular crest, bulboventricular fold, area of the fibrous tissue between the aortal and mitral valves and the anterior interventricular septum make the walls (frontal view, in the direction of the hour hand) of the left ventricular cone. In the normal heart there is no real contact between the fibrous rings of the aortal and mitral valves. They are connected by means of a strip of the fibrous tissue, its size varies. The subaortal cone and deferent part of the left ventricular axes make an obtuse angle; the axes of the subpulmonary and subaortal cones have a cross direction. The geometrically definitive left ventricular cone is seen as obliquely-sectioned overturned isosceles cone, with its big base directed upward, right and back, and the small one forward and left.

Adolescent↗
PubMed1991

[Anatomic and hemodynamic comparisons in patients with aorta and pulmonary artery arising from the right ventricle].

The anatomy and hemodynamics were compared in 59 patients with aorta and pulmonary artery origin from the right ventricle. The patients' age was from 3 months to 23.5 years. The pathophysiology of the patients' circulation was determined by many factors, the most important factors were the following: the anatomic type of the malformation, the presence or absence of pulmonary and aortic stenoses and other concurrent congenital heart malformations. The oxygen saturation of the arterial blood was associated with the direction of physiological blood flows in the right ventricle. The most "successful" anatomic and hemodynamic variants of the malformation were types A and B, in which there was no higher blood oxygen saturation in the pulmonary artery as compared to the level of blood oxygenation in the aorta despite the presence or absence of pulmonary stenosis and the site of great vessels. Type C with the inverse site of great arteries is the less "successful" anatomic and hemodynamic variant.

Adolescent↗
PubMed1991

Angiocardiographic diagnosis of ventricular septal defect localization in double outlet right ventricle.

Children with double outlet right ventricle, aged 3 months to 23.5 years, were examined to assess the possibility of angiocardiographic diagnosis of defect localization. It was found angiocardiography allows satisfactory localization of the defect in question. To be able localize the defect, it is critical to determine the interaction between the defect and the conus septum, and the origin of large arteries. To establish the diagnosis of ventricular septal defect, right and left ventriculography in standard and axial projections must be performed.

Abnormalities, Multiple↗
PubMed1991

[Classification of aortic and pulmonary artery origin from right ventricle].

An original systematics of origin of the aorta and pulmonary artery from the right ventricle (OAPA RV) is suggested on the basis of examination of 63 heart specimens with the anomaly. Two main variants of OAPA RV are distinguished: (1) with and (2) without a formed infundibular septum (IS). Types A and DA belong to the first variant, types B, C, D, and DC to the second variant. Type A is characterized by drainage of the left ventricular (LV) outflow tract (OT) into the subaortic conus. Type DA differs from type A by the existence of an auxiliary opening between the ventricles due to a deficiency of tissue of the posterior (sinus part) of the septum. Type B is characterized by the absence (or marked hypoplasia) of the septum of the conus (SC). The LV OT in this case drains under both (aortic and pulmonary) coni. In type C the LV OT opens into the subpulmonary conus. In distinction from type C, type DC has an auxiliary defect in the sinus part of the interventricular septum (IVS). Type D is characterized by complete obturation of the exit and the absence of a defect in the sinus part of the IVS (type D1: OAPA RV with an intact IVS) or with a sinus defect in the IVS-DIVS (type D2: OAPA RV with noncommitted DIVS). According to the presence or absence of stenosis of the pulmonary artery (PA) or aorta, 4 subtypes are distinguished: (1) without stenosis; (2) with stenosis of PA; (3) with aortic stenosis; (4) with combined aortic and pulmonary stenosis.

Adolescent↗
PubMed1991

[The anatomy of the interventricular septum of the heart and the anatomical nomenclature].

With the aim to study interrelations of the interventricular septum (IVS) and systematization of their definitions, 151 preparations of hearts of persons died from causes having no connections with cardio-vascular diseases have been studied. The IVS consists of inflow and outflow septa. The inflow septum includes the sinusal (posterior) and trabecular septa, the outflow one--the anterior and conoid septa. The distal part of the anterior and conoid septa form the infundibular septum. From the side of the right ventricle the conoid septum and bulboventricular fold form a supraventricular crest--muscular torus, separating its inflow and outflow parts. From the side of the left ventricle the supraventricular crest is seen as a muscular bar, forming the basal medial wall.

Heart Septum↗
PubMed1990

[Anomalies of atrioventricular valves in origin of the aorta and pulmonary artery from the right heart ventricle].

Anomalies of the atrioventricular valves may influence essentially the choice of the method and volume of surgical intervention in origin of the aorta and pulmonary artery (PA) from the right ventricle (RV). The results of morphological study of 55 heart specimens with origin of the aorta and PA from the RV are analysed; structural anomalies of the atrioventricular valves were revealed in 19 of them (34.5%). The anomalies were surgically significant only in 16.4% of cases. Isolated anomalies of biventricular attachment, simultaneous biventricular attachment and displacement of one of the atrioventricular valves, and anomalous chordae and supernumerary fibrous structures connected to the atrioventricular valves, etc. were the most commonly encountered anomalies of the atrioventricular valves in origin of the aorta and PA from the RV. The frequency and complexity of anomalies of the atrioventricular valves in origin of the aorta and PA from the RV were determined by the morphology of the cardiac complex, the type of the anomaly, and the side involved in the pathology of the atrioventricular valves. The complexity of the atrioventricular valve disorders in such cases could influence noticeably the volume of the surgical intervention. Anomalies of the atrioventricular valves in origin of the aorta and PA from the RV were encountered most frequently in malposition of the heart or discordant atrioventricular connection. The frequency of anomalies of the tricuspid valve was much higher than that of mitral valve anomalies, but the last named were surgically significant in most cases as a rule.

Adolescent↗
PubMed1990

[The anatomical criteria of the origin of the aorta and pulmonary artery from the right ventricle].

New anatomical criteria of the above malformation are created on the basis of the study of 63 hearts with the origin of aorta and lung artery from the right ventricle: the presence of the bulboventricular fold separating the mitral and semilunar valves; complete or partial delay of the subaortal cone movement to the left ventricle; the presence of the completely or partially formed proximal cone; underdevelopment of the left ventricle due to the complete or partial absence of its cone region; the only issue from the left ventricle is the proximal cone apertures or a part of the primary bulboventricular orifice; when the primary bulboventricular orifice is obturated the left ventricle is either deprived of the opening or has it in the form of noncommitted defect in the sinusal part of the interventricular septum; the anterior margins of the bulboventricular fold and cone septum are open and supraventricular comb is not formed; the interventricular septum defect formed due to failure of fusion between bulboventricular fold and cone septum connects the aorta with the right ventricle; aorta and lung artery start completely or partially from the right ventricle.

Adolescent↗
PubMed1989

[Quantitative evaluation of normal mitral and tricuspid valves (comparison of the data of echocardiometric and morphometric studies)].

Fifteen children, aged 5 to 15 years, were investigated by two-dimensional echocardiography in order to estimate quantitative characteristics of the normal mitral valve (MV) and tricuspid valve (TV). The results were compared to morphometric data in 21 children matched for age. Echocardiography allowed a fairly accurate estimation of the dimensions of atrioventricular valves. Following the standardization procedure, echocardiometric findings showed good correlation to morphometric data, while the differences between the two never exceeded 23%. Quantitative MV and TV characteristics were dependent on body surface area, but, the dependence being nonlinear, the variation followed a strict pattern.

Adolescent↗