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Biomedical subjects

I Hindberg

Publications and source records attributed to I Hindberg.

At least 37 records · Page 2Linked to original sources
PubMed1985

Platelet function in surgical stress.

Ten patients for elective cholecystectomy were studied pre-, per-and postoperatively. All had neurolept anesthesia. Plasma concentrations of beta-TG, TXB2 and 5-HT and intraplatelet 5-HT were measured. Aggregation to ADP was recorded. Serum cortisol concentration was used as index of the stress response, showing peroperative increase and postoperative decrease. Closely related to this we observed a significant increase in P--beta-TG and P-TXB2 with postoperative normalization in 6 patients without complications. P--5-HT had a peak peroperatively and remained elevated postoperatively. A negative correlation between P--5-HT and decreasing intraplatelet 5-HT postoperatively was observed. High postoperative levels of P--5-HT seem to be related to low arterial PO2 and pulmonary dysfunction. In 3 patients with complications a second increase in P--beta-TG, P-TXB2 and partly in P--5-HT was found. Platelets were temporarily refractory to ADP immediately following surgery and showed increased aggregability postoperatively. We conclude that platelets are activated in surgical stress.

Adenosine Diphosphate↗
PubMed1984

An improved specific and sensitive radioenzymatic method for determination of serotonin concentrations in biological fluids (radioenzymatic serotonin method).

Existing radioenzymatic assays for determining the concentration of serotonin in biological fluids have been further modified resulting in increased sensitivity and a lowered detection limit (0.017 pmol). The assay has been used for determinations in platelet-poor plasma (3.3-20.5 nmol/l) and cerebrospinal fluid (0.15-20 nmol/l) from man.

Chromatography, Thin Layer↗
PubMedDate not supplied

Acute appendicitis and plasma concentration of serotonin.

The concentration of serotonin in platelet-poor plasma was measured with a radioenzymatic method in 31 patients prior to operation for suspected acute appendicitis. The serotonin determinations were made without knowledge of the peroperative or histologic findings. Appendicitis was found in 20 patients, nine of whom had elevated plasma serotonin level, giving 45% sensitivity for the test. Of the 11 patients with normal appendix, only one had increased plasma serotonin, giving 91% specificity. The predictive value of normal serotonin level was 48% and that of elevated serotonin level was 90%. No correlation was found between duration of appendicitis symptoms and plasma serotonin concentration. Other diseases did not influence the serotonin level.

Acute Disease↗