Biomedical subjects

I Hickie

Publications and source records attributed to I Hickie.

113 records · Page 7Linked to original sources

PubMed1990

Classifying depression by mental state signs.

The possibility that separation of a categorical depressive disease ('melancholia') from remaining depressive disorders can be improved by assessment of mental state signs was examined in patients treated by representative Sydney psychiatrists and patients referred to a specialised mood disorders unit. A set of signs, principally assessing retardation, was derived within the two samples by principal-components and latent-class analyses. Scores were significantly correlated with clinical, DSM-III, and RDC diagnoses, and appeared independent of severity, suggesting that melancholia can be defined phenomenologically. Scores were also associated with several 'validating' factors. Comparative analyses of a refined list of melancholia symptoms suggested that ratings of defined signs are likely to have greater capacity than symptom ratings to differentiate melancholia from residual depressive disorders.

Adjustment Disorders↗

PubMed1990

Prediction of response to electroconvulsive therapy. Preliminary validation of a sign-based typology of depression.

In an open study of 35 depressed patients, psychomotor disturbance, assessed by the CORE rating system, significantly predicted response to ECT in patients with a 'retarded' but not those with an 'agitated' type of illness. In multivariate analyses, psychomotor disturbance was the sole predictor of response. This preliminary study suggests that the CORE system, which has been shown to differentiate endogenous and non-endogenous depressive disorders, has predictive validity in relation to ECT response.

Adult↗

PubMed1990

Hormonal responses to fenfluramine in depressive subtypes.

In order to study putative differences in central neurotransmitter function in depressive subtypes, serum cortisol and prolactin responses to the putative serotonin agonist fenfluramine were examined in 30 subjects with major depression. Patients with endogenous depression (melancholia) as defined by each of ICD-9, DSM-III, RDC and Newcastle scale demonstrated a reduced prolactin response to 60 mg oral fenfluramine when compared with non-endogenous subjects. This was independent of either prolactin or cortisol baseline levels, and indicates that there are differences in brain neurotransmitter function in the endogenous and non-endogenous subtypes of depression. Basal prolactin levels were reduced in bipolar compared with unipolar subjects, and delusional compared with non-delusional patients, although there were no differences in the prolactin responses to fenfluramine between these subgroups. Basal cortisol levels and cortisol response to fenfluramine did not distinguish between any of the subtypes.

Administration, Oral↗

PubMed1989

Anorexia nervosa presenting in a prepubertal boy.

A case of anorexia nervosa that presented in a prepubertal boy is reported. It seemed that particular maternal attitudes towards dieting, paternal criticism of the boy's body shape and size, and severe family disruption were the major factors in the aetiology of this disorder. If such attitudes to food intake and body size and shape and major family disruptions become more prevalent in the community, then one might expect to see an increase in the prevalence of this serious disorder in younger children, which results in serious physical and psychological sequelae.

Anorexia Nervosa↗

PubMed1989

A family panics.

We report the treatment of a family in which both spouses developed panic disorder, and their son, school phobia, soon after the death of a close relative. The interactional style observed within this family suggested that interpersonal factors were important in the generation of anxiety in each member. Detailed case histories such as the one we report underscore the importance of a systemic perspective when assessing individuals who present with anxiety disorders.

Adult↗