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Biomedical subjects

I Hassan

Publications and source records attributed to I Hassan.

64 records · Page 4Linked to original sources
PubMed1983

Progression in idiopathic scoliosis after conservative treatment.

One hundred patients with idiopathic scoliosis treated conservatively were reviewed for a mean period of 10.6 years after the end of treatment. The majority of curves had increased; 70% between 16 and 20 years of age and 60% after age 20. The mean progression per year was 3 degrees and 2 degrees for single and double curves, respectively, in the first 4 years after the end of treatment and 1 degree and 0.5 degrees, respectively, in adulthood. Curves above 40 degrees increased significantly more than smaller curves. It is concluded that curves of more than 40 degrees, especially thoracic single curves, should be treated operatively in adolescence. Conservative treatment of smaller curves should be continued towards 20 years of age, and the patients should be followed up during early adult life.

Adolescent↗
PubMed1982

Progression in untreated idiopathic scoliosis after end of growth.

Seventy patients more than 16 years of age with untreated idiopathic scoliosis were followed-up for a mean period of 8.5 years. The majority of curves increased; 3 degrees per year before 20 of age and 1 degree per year after 20 years. Curves below 40 degrees increased significantly less than bigger curves and curves from 60-80 degrees increased the most. Single curves increased significantly more than double curves; thoracic curves increased significantly more than lumbar curves. It is concluded that surgery should be recommended to adolescent patients with thoracic or thoraco-lumbar single curves larger than 40 degrees, and that patients not treated operatively should be followed-up through early adult life.

Adolescent↗
PubMed1976

Cauda equina syndrome in ankylosing spondylitis: a report of six cases.

Six patients with ankylosing spondylitis and features of a cauda equina syndrome are described. The myelographic findings are discussed in relation to the pathogenesis of the disorder and its natural history. Present experience suggests that the cauda equina syndrome is a more common complication of ankylosing spondylitis than is usually thought.

Cauda Equina↗
PubMedDate not supplied

Outcome of patients undergoing ileal pouch-anal anastomosis for left-sided chronic ulcerative colitis.

Chronic ulcerative colitis is not a uniform disease entity because the clinical pattern and disease characteristics differ on the basis of the anatomic location of the inflammation. The aim of this study was to compare the preoperative characteristics, postoperative complications, and long-term functional outcome of ileal pouch-anal anastomosis (IPAA) in patients with left-sided colitis to those same characteristics in patients with pancolitis. Between 1990 and 1996, a total of 565 patients underwent IPAA for chronic ulcerative colitis at our institution. Of these, 111 patients were determined to have left-sided involvement, whereas 283 patients had pancolitis. The mean age at surgery was greater in the patients with left-sided colitis (37 years vs. 34 years, P = 0.01), and the mean duration of disease (8.7 years vs. 7.7 years, P = 0.05) tended toward a significant difference between the left-sided colitis and pancolitis groups. The complication rates were similar with the exception of small bowel obstructions, for which there was a higher incidence in the group with left-sided colitis (27% vs. 13%, P = 0.002) at 5 years. The incidence of pouchitis (43% vs. 39%) at 5 years was comparable. Long-term functional results and quality-of-life assessment did not show any significant differences between the two groups. We were unable to detect any correlation between the extent of colon involvement and the subsequent incidence of pouchitis, long-term pouch function, and quality of life. Patients with left-sided colitis were older, had a relatively longer duration of disease, and were at increased risk for postoperative small bowel obstruction as compared to patients with pancolitis.

Adult↗
PubMedDate not supplied

Antisense p53 oligonucleotides inhibit proliferation and induce chemosensitivity in follicular thyroid cancer cells.

BACKGROUND: The potential of MTp53 knockout by oligodesoxyribonucleotide phosphothioates (ODNs) to affect proliferation, apoptosis and chemosensitivity in undifferentiated thyroid cancer (UTC) cells with a recessive MTp53 mutation was evaluated. MATERIALS AND METHODS: Transient transfections with ODNs complementary to p53 and control ODN (HIV-RT) were carried out in FTC 133 cells. In vitro proliferation was evaluated by cell counting of 10 random fields and by the MTT assay. A single pulse of 100 microg/ml Cytarabine was added to each well and the cells were incubated for an additional day. Chemosensitivity was calculated as the ratio of apoptotic and necrotic cells versus viable cells by flow cytometry (FACS). RESULTS: Transfection of UTC cells with ODN decreased the cell number by up to 70% (p < 0.002). The proliferation rate also decreased up to 35% (p < 0.03), without inducing apoptosis. ODNs rendered FTC cells sensitive to treatment with Cytarabine, inducing apoptosis in 35% of cells, as compared to 17% of cells transfected with the reverse transcriptase gene of HIV (ODN-HIV) and less than 10% of non-transfected cells (p < 0.05). CONCLUSION: Transient MTp53 knockout with ODNs complementary to p53 nucleotide sequences inhibited proliferation and increased chemosensitivity in the UTC cell line FTC133.

Adenocarcinoma, Follicular↗
PubMedDate not supplied

Bilateral axillary and suprascapular neuropathy after coronary artery bypass surgery.

Neuropathies after coronary artery bypass (CABG) and cardiac surgery are usually transient and have been described fairly frequently. Our patient presented with an acute onset of a surprisingly symmetrical bilateral axillary and suprascapular neuropathy during the immediate CABG period (which to our knowledge has not been reported on before). The patient, aged 64 years, suffered from diabetes mellitus type 2 and hypertension, and underwent a triple CABG. Electroneuronographic and electromyographic examination confirmed the presence of the bilateral axillary and suprascapular neuropathy, which showed only minimal improvement 15 months later. The surmise is that the neuropathy developed as a result of compression or overstretching of the involved nerves during the surgical procedure, associated with suboptimal positioning of the arms. The 'hands-up position', with careful sternal retraction (Cooley retractor), may appear to prevent the posterior displacement of the shoulders and plexus injuries. The diabetes mellitus may have acted as an aggravating factor.

Coronary Artery Bypass↗