Search PubMed⌕ Search

Biomedical subjects

I Hashimoto

Publications and source records attributed to I Hashimoto.

At least 343 records · Page 19Linked to original sources
PubMed1979

Bilaterally recorded brain stem auditory evoked responses. Their asymmetric abnormalities and lesions of the brain stem.

Simultaneous bilateral recordings (C3 to A1 and C4 to A2) of brain stem auditory evoked responses have been studied in 67 supratentorial lesions, nine midbrain lesions, 21 intrinsic pontine lesions, and 23 extrinsic compressions of the pons. The responses in supratentorial lesions showed completely normal records. In midbrain lesions, wave V was specifically altered. As wave 1 has been shown to be a far-field seventh nerve potential, and wave V the midbrain potential, waves II to IV can be inferred to originate in the central auditory pathway between the seventh nerve and the midbrain. Alterations of waves II to IV correlated well with localization of pontine lesions, and asymmetric alterations of the bilaterally recorded responses were associated with unilateral lesions of the brain stem auditory pathway and/or lesions of the crossed auditory projections.

Acoustic Stimulation↗
PubMed1979

The role of extracellular potassium in early epilepsy.

Clinical studies indicate that early epilepsy after injury may be associated with some transient and reversible pathophysical processes of the brain. It has been proposed that epileptogenesis in the neocortex and hippocampus may be related to potassium ion accumulation in extracellular spaces. To investigate this hypothesis, we measured [K+]0 using potassium-sensitive microelectrodes in the sensorimotor cortex of cats during early seizures induced by trauma. The [K+]0 increases associated with seizure activity ranged from 14.6 to 25.1 mM, and these were significantly higher than those unassociated with spikes or seizure discharges. Moreover, high K+ solutions (15 mM or more) directly applied to the cortex produced spiking and seizures. These results seem to support the hypothesis that accumulation of [K+]0 is related to development of early epilepsy.

Animals↗
PubMed1979

[Clinical studies of cefmetazole (author's transl)].

1. Cefmetazole was administered to 10 patients; 5 acute cholecystitis, 4 acute peritonitis and 1 periproctitis. 2. Cefmetazole was given by drip infusion at a daily dose of 2 to 4 g. 3. Clinical response was excellent in 3 patients, and good in other 7 patients. 4. No clinical adverse effect was recognized except the increase of GOT and GPT in 1 patient.

Adolescent↗
PubMed1978

Neurovirulence in cynomolgus monkeys of enterovirus 71 isolated from a patient with hand, foot and mouth disease.

Six cynomolgus monkeys were inoculated subcutaneously with enteroviurs 71 (E71), isolated from the stools of a patient with hand, foot and mouth disease (HFMD). Clinical symptoms were observed in three of the six monkeys. One monkey showed complete paralysis of the lower extremities and two animals showed weakness in the hind limbs 4 to 7 days after inoculation. Lesions were found in the central nervous system (CNS) of all monkeys. Mild to moderate vascular lesions, perivascular cuffings, degeneration and disappearance of the neurons and meningial lymphocytic infiltration were observed in the grey and/or white matter of the spinal cord, medulla oblongata, cerebral cortex and brain stem. No virus was recovered from the CNS or liver of any of the six monkeys. However, serum neutralizing antibody titers had risen in monkeys inoculated with E71.

Animals↗
PubMed1978

Myocardial changes after infection with Coxsackie virus B3 in nude mice.

Athymic BALB/c-nu/nu (nu/nu) mice were inoculated i.p. with Coxsackie virus B3. The infected nu/nu mice were studied histopathologically, virologically and serologically in comparison with BALB/c-nu/+ (nu/+), BALB/c-+/+(+/+) and conventional ddY/S mice inoculated with the same virus. The virus titre in the hearts of nu/nu mice was roughly similar to that of nu/+ or +/+ and was higher than that of ddY/S. The neutralizing antibody titre in nu/nu mice was slightly lower than that of nu/+ or +/+ mice and somewhat lower than that of ddY/S mice. Histopathologically, there was a lack of mononuclear cells in myocarditis produced by Coxsackie virus B3 in athymic nu/nu mice. In contrast, myocarditis with mononuclear cell infiltrations were found in nu/+, +/+ and ddY/S mice. The lack of mononuclear cell reaction was a distinguishing difference in the myocardial changes of athymic nu/nu mice from those in nu/+, +/+ and ddY/S mice. The incidence in the myocardial lesions of nu/nu mice was about the same as those in nu/+, +/+ and ddY/S mice. However, the intensity of the myocardial changes of nu/nu mice was significantly less than that of other three groups. From the histopathological viewpoint, it is suggested that inflammatory response in the myocardium of mice infected with Coxsackie virus B3 is thymus-dependent.

Animals↗