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Biomedical subjects

I Hashimoto

Publications and source records attributed to I Hashimoto.

At least 307 records · Page 17Linked to original sources
PubMed1982

A patient with gastric carcinoma improved remarkably on intraperitoneal OK-432 therapy.

A patient with an abdominal tumor and gastric cancer was treated with intraperitoneal OK-432 alone. Her general condition improved and the abdominal mass diminished significantly. The fluoroscopic radiography and gastroduodenal fiberscopic examinations revealed a slight improvement. Four months after the initiation of OK-432 therapy, microscopic examination of the biopsy specimen disclosed degenerated tumor cells with a pronounced accumulation of lymphocytes and large monocytes which were ascertained to be macrophages by the fluorescent antibody technique using anti-macrophage serum. This study revealed one possible mechanism of the antitumor action of OK-432.

Biological Products↗
PubMed1982

Auditory evoked potentials from the human midbrain: slow brain stem responses.

Slow brain stem auditory evoked potentials (BAEP) were recorded in humans from depth electrodes in the thalamus and from movable electrodes within the IVth ventricle (the vicinity of the pons), the aqueduct of Sylvius (the midbrain), the IIIrd ventricle (the thalamus) and the lateral ventricle. The slow potentials consist of the positive wave peaking at 5-6 msec, and two large negative waves: No (8-10 msec) and Na (12-17 msec) in the nomenclature of Picton et al. (1974). The sources of these slow negative waves have been identified, on the basis of observation of amplitude increase in depth recordings and by tracing these potentials from their intracranial maximum to the scalp. Both No and Na have their origins in the midbrain, probably representing postsynaptic activities within the inferior colliculus. No comparable slow waves were recorded from the medial geniculate body. The present observations give a basis for non-invasive evaluation of patients with midbrain dysfunction.

Brain Stem↗
PubMed1982

Liver-protective actions of desoxypodophyllotoxin and its analogs.

Effects on CCl(4)-induced liver lesion in mice and on D-galactosamine-induced liver lesion in rats of desoxypodophyllotoxin (1) and its analogs, podophyllotoxin (2), podophyllotoxon (3), beta-peltatin (4), alpha-peltatin (5), 4'-demethylpodophyllotoxin (6) and picropodophyllin (7), were investigated. 1 and 7 in CCl(4)-induced liver lesion and 1,4,5, and 6 in D-galactosamine-induced liver lesion have shown marked protective actions. These results suggest that these analogs have liver-protective actions in general and the substituents at C-4 in ring C, C-5 in ring B and C-4' in ring E, and the configuration at C-2 in ring C are important for the revelation of the activity.

Alanine Transaminase↗
PubMed1982

Exercise-induced glycogenolysis in sympathectomized rats.

The role of the adrenergic system in regulating glycogenolysis during exercise was studied in rats. Alterations in the adrenergic system were produced by injections of 6-hydroxydopamine (6-OHD), surgical removal of the adrenal medulla (ADMX), or the combination of ADMX and 6-OHD injection. Exercise was treadmill running at 22 m/min for 60 min. Colonic temperature averaged 2.8 degrees C higher in the exercised than control rats. Exercise reduced the glycogen of the liver and skeletal muscles of all groups. The glycogen concentrations of the soleus and red portion of the gastrocnemius muscles of the ADMX and ADMX-6-OHD groups were about 3.8 and 2.5 times higher after exercise than those of the normal-exercised rats. Glycogen depletion of the white portion of the gastrocnemius muscle was similar for all exercised groups. 6-OHD treatment depleted the catecholamines of the myocardium. These results demonstrate that glycogen depletion during exercise occurs in rats devoid of adrenergic control. However, differences between types of skeletal muscle suggest that factors other than the adrenergic system may be involved in controlling glycogen metabolism during exercise.

Adrenal Medulla↗
PubMed1982

[Effect of levamisole in postoperative adjuvant immunochemotherapy of stomach cancer--randomized controlled study of MMC-tegafur combination therapy with or without levamisole. 1].

The effects of levamisole used in combination with Mitomycin C and Tegafur in patients with resectable stomach cancer were investigated in 10 cooperative institutes. The patients were randomly allocated to the treatment with either control or levamisole by envelope method. Levamisole group was treated with Mitomycin C (day 0, 20 mg, day 1, 10 mg, one shot i.v.), Tegafur (600 mg/day, p.o.) and levamisole (150 mg/day, p.o.). Levamisole was administered 3 consecutive days prior to surgery, and 3 consecutive days every fortnight after surgery. The control group was administered Mitomycin C and Tegafur. The both drugs were administered by the same method as above. Two hundred and twenty-two patients were entered in this trial. However, with the exclusion of 67 patients, the eligible patients were 155, consisting of 77 in the control group and 78 in the levamisole group. In stage III patients, the disease-free interval and survival time were significantly prolonged in the levamisole group compared to the control group (generalized Wilcoxon test p less than 0.05). The side effects were observed a little more frequently in the levamisole group. However, there was no significant difference. From this result, it can be considered that levamisole is effective in delaying recurrence and in prolonging survival time of the patients when used in combination with adjuvant chemotherapy after resection of stomach cancer.

Adjuvants, Immunologic↗
PubMed1982

Auditory evoked potentials recorded directly from the human VIIIth nerve and brain stem: origins of their fast and slow components.

Brain stem auditory evoked potentials in humans are composed of fast pseudorhythmic positive waves and slow positive and negative waves. The sources of these components have been identified on the basis of the observation of amplitude increase in depth records during surgery and by tracing these potentials from their intracranial maximum to the scalp by using movable electrodes within the IVth, IIIrd and lateral ventricles. The first wave I represents postsynaptic activities of the first auditory neurones; axonal volleys travelling along the auditory nerve do not contribute to this wave, which is obviously discrepant with the currently accepted view. Waves II and III are primarily generated within the pons, with possible contributions from the auditory nerve. Waves IV and VI originate from the pons and the medial geniculate body respectively. Both slow positive and negative waves have their origin in the inferior colliculus (IC). The slow positive waves probably represent incoming axonal volley and the negative waves, the postsynaptic potentials in the IC.

Axons↗
PubMed1982

Effects of fluorocarbon infusion on microcirculation during cardiopulmonary bypass.

A pulsatile pump was used to effect a three-hour cardiopulmonary bypass in 15 mongrel dogs. During the bypass, Fluosol-DA (35%) infusion was used in lieu of homologous blood transfusions. The greater omentum was chosen as a model of extraorganic microcirculation, and its reaction to the infusion was observed. The omentum's microcirculation was not adversely affected by the Fluosol-DA (35%): no sludging, microthrombi, arteriovenous fistulas, plasma skimming, stasis, or other adverse findings were observed. The animals' oxygen consumption did not decrease, and the resistance of the systemic blood vessels, did not increase during the experiment, suggesting that the fluorocarbon infusion had no untoward effects on the microcirculation.

Animals↗
PubMed1982

[Clinical studies on amikacin for infectious diseases following intravenous drip infusion (author's transl)].

An antibiotic drug of aminoglycoside group, amikacin (AMK) for parenteral use was used to 8 hospitalized patients: 4 with acute or subacute cholecystitis and cholangitis, 4 with acute peritonitis (3 cases were due to acute appendicitis and a case was torsion of right ovarian cyst). AMK in a dose of 200 mg were administered by intravenous drip infusion for 1 to 2 hours, twice a day for 4 to 9 days. To the cases with biliary tract infection, AMK was treated to preoperatively and to the cases with acute peritonitis, AMK was treated to the postoperatively. Clinical response was excellent in 2 cases, good in 6 cases, fair and poor in none. No adverse effect was observed. The organisms were isolated in 4 cases, 4 were Escherichia coli, 1 was Klebsiella pneumoniae and 1 was Bacteroides fragilis. The MIC for AMK were 3.13-1.56 micrograms/ml in 10(8) and 10(6) cells/ml, except Bacteroides fragilis. Before the operation of above cases, AMK in a dose of 200 mg were administered by intravenous drip infusion in 2 cases (acute and subacute cholecystitis and cholangitis with cholelithiasis), 5 cases by intramuscularly and 1 case by intravenously (acute appendicitis with localized peritonitis). The materials of A-bile, B-bile, wall of gallbladder, the appendix, ascites and serum samples were taken during the operation. AMK concentration was measured by bioassay method with Bacillus subtilis ATCC 6633 as test organism. AMK concentration in B-bile were higher than those in the A-bile. AMK concentrations in wall of gallbladder were much higher than those in A and B-bile. The concentrations after intravenous drip infusion were higher than those after intramuscularly administration. AMK changes of inflammation. In a case of gastric ulcer, AMK 200 mg by intravenous drip infusion was administrated, the AMK concentrations of the tissues at 25 minutes after end of infusion, they were 15.00 micrograms/g in gastric ulcer, 7.20 micrograms/g in normal gastric wall, 9.14 micrograms/g in duodenal wall and 8.12 micrograms/g in the omentum, respectively. Serum concentration of AMK on this case at 58 minutes was 15.7 micrograms/ml. Therefore, it was supposed that AMK could be used safety and effective by intravenous drip infusion.

Acute Disease↗
PubMed1982

[Evaluation of postoperative long-term chemotherapy using FT-207 for the stage III stomach cancer].

The effect of postoperative adjuvant chemotherapy on survival rate of gastric cancer patients of Stage III was evaluated. Ninety-nine patients evaluated as Stage III according to the general rules for surgical studies on cancer of the stomach received surgical treatments at our Department in the period of 1967 to 1978. Patients were classified into following three groups: (A) no chemotherapy group (54 cases) (B) short term chemotherapy group (15 cases, receiving chemotherapy postoperatively for 20 days) (C) long term chemotherapy group (30 cases, more than 3 months postoperatively and more than 60 g of total dose of FT-207) Three-year survival rates of the patients were 40.7% in (A) group, 26.7% in (B) and 66.7% in (C), respectively. These results suggested that a long term postoperative chemotherapy significantly prolonged the survival times of gastric cancer patients in Stage III (C vs B: P less than 0.02, C vs A: P less than 0.03). On the other hand, a short term chemotherapy after surgery decreased the survival rate when comparing with no chemotherapy group, possibly due to impairment of host's anticancer immunity.

Drug Administration Schedule↗
PubMed1981

Brain-stem auditory-evoked potentials recorded directly from human brain-stem and thalamus.

Brain-stem auditory-evoked potentials were recorded in neurosurgical patients from surface electrodes applied to the VIIIth nerve, medulla, pons, midbrain and cortex; from depth electrodes in the thalamus; and from a movable electrode in the IVth, IIIrd, and lateral ventricles. The potentials recordable over the scalp within 10 ms after click stimulation are characterized by a slow positive wave (peaking at 5 to 6 ms) and a negative wave (8 to 10 ms) with 7 small positive wavelets superimposed upon them. The sources of these components have been identified by observing their increased amplitude in depth recordings, and by tracing the potentials from their intracranial maxima to the scalp. Wave I is generated within the most distal portion of the VIII nerve; Wave V in the midbrain (inferior colliculus); and Wave VI the medial geniculate body. Both low positive and negative components have their origins in the inferior colliculus. Intracranially-recorded brain-stem auditory-evoked potential showed very rapid changes in amplitude within the brain-stem but only slight changes in the more rostral regions, although their amplitude gradients varied in the different components. They also demonstrated minor but systematic shifts in latency with distance from the potential sources, reflecting a significant overlap of separate potentials. This effect must be taken into account in the interpretation of a 'concurrent' intracranial potential as the source of a far-field surface-recorded potential.

Auditory Pathways↗
PubMed1981

[Studies on cefotaxime (HR 756) concentration in human biliary tract and clinical effect for acute or subacute cholecystitis with cholelithiasis (author's transl)].

A new antibiotic drug of cephalosporin with marked resistance to beta-lactamase, cefotaxime (HR 756) for parenteral use in 8 patients with acute or subacute cholecystitis with cholelithiasis. Cefotaxime was administrated by intravenous injection or drip infusion at a daily dose of 1-4 g. Clinical response was excellent in 1 case, good in 7 cases, and fair or poor was none. Clinical adverse effect was not recognized. Cefotaxime in a dose of 1 g was given intravenously during operation to those same 8 patients. Tissue specimens of different places were taken from removed organs. The materials of A-bile and B-bile were subsequently taken at intervals. Determination of cefotaxime concentration was performed according to the bioassay method with Micrococcus luteus ATCC 9341 strain. Cefotaxime concentrations in the A-bile increased gradually until 1 hour after the intravenous administration. Cefotaxime was observed in the B-bile through the gallbladder wall after the intravenous injection.

Adult↗