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Biomedical subjects

I Hamilton

Publications and source records attributed to I Hamilton.

At least 37 records · Page 2Linked to original sources
PubMed1991

Duodenal ulcer relapse after eradication of Helicobacter pylori.

Thirty-six patients with healed duodenal ulcers, 27 infected with Helicobacter pylori and nine uninfected, were followed for up to 12 months to determine the rate of ulcer relapse. Eight patients withdrew over the follow up period. At one year, 15 of 20 (75%) infected patients and one of eight (13%) uninfected patients had relapsed, p less than 0.05. Eradication of H pylori favourably influences the natural history of duodenal ulcer recurrence. Significant patient morbidity may be prevented by using measures to eradicate H pylori during or after duodenal ulcer healing.

Amoxicillin↗
PubMed1991

Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride.

A case of chronic intestinal pseudoobstruction secondary to systemic amyloidosis in a patient with multiple myeloma is described. Gastrointestinal symptoms and indices of nutrition improved markedly after commencing treatment with cisapride, which may have been responsible for relatively prolonged survival compared with similar reported cases.

Amyloidosis↗
PubMed1990

Evaluation of a practice information leaflet.

Over 10 months 5,000 practice information leaflets were distributed in a practice in Glasgow. The leaflet was principally evaluated by assessing patients' attitudes to and use of leaflets and changes in their knowledge about the practice. Changes in the pattern of consultation with the practice nurse and the timing of incoming telephone calls were also measured. Most patients read, kept and referred to the leaflet and reported it to be useful. Those who had seen the leaflet had significantly greater knowledge (mean knowledge score 7.5) on 15 questions on practice organization than two comparison groups: the base-line study sample (mean knowledge score 5.2) and those in the follow-up sample who had not seen the leaflet (mean knowledge score 5.7). Improvements in knowledge were statistically significant for 10 out of 15 questions. Two changes of behaviour were noted, increased self-referral to nurses (37% of new consultations at follow-up were self-referred compared with 29% at baseline: P = 0.05) and the timing of incoming telephone calls was more in line with practice policy (for example, 23% of calls for repeat prescriptions were made between 12.00 and 16.00 hours at follow-up compared with only 11% at baseline, P less than 0.001). The leaflet was judged to be useful.

Adolescent↗
PubMed1990

Effects of human and ovine pancreatic secretory trypsin inhibitors on the proliferation of normal human fibroblasts.

Human pancreatic secretory trypsin inhibitor inhibited cell-surface proteolytic activity in human fibroblasts. In the range of concentrations which caused proteinase inhibition, fibroblast proliferation was also inhibited by this reagent and by the ovine equivalent. At lower concentrations, there was some evidence for a mitogenic effect, and this was confirmed by obvious stimulation of DNA synthesis at these concentrations. Human alpha 1-proteinase inhibitor, previously demonstrated to be an inhibitor of fibroblast proliferation, was also mitogenic at concentrations lower than those which inhibited proteolytic activity and cell proliferation. Human pancreatic secretory trypsin inhibitor and epidermal growth factor apparently work through independent mechanisms, since their mitogenic effects are additive.

Animals↗
PubMed1990

Introduction of an appointment system in a general practice: surveys of patients and staff.

To aid discussion on the introduction of an appointment system in an inner city practice with a 'walk-in' (non-appointment) system, we surveyed, firstly, patients' and staff members' attitudes to appointment systems, and secondly, aspects of the functioning of the current system. Of 250 patients in the first survey 73 per cent were against appointment systems while 24 per cent indicated that they would consider registering with another practice if such a system were introduced. Adverse comments about appointment systems greatly outweighed favourable ones. Staff members perceived clear advantages and disadvantages of both methods of consulting e.g. the 'walk-in' system was thought to be stressful due to the unpredictable workload but thought to reduce the demand for housecalls. Appointment systems were seen as giving staff more control over consulting but as less flexible for the patient. In the second survey of 352 patients, 17 per cent estimated a wait of 10 minutes or less for their consultation, 62 per cent estimated it as 10 to 20 minutes and 21 per cent as more than 30 minutes. Further, 68 per cent of patients estimated that their consultation lasted five minutes or less and 27 per cent indicated that the doctor seemed rushed. As a compromise between the wishes of patients and the needs of staff, 'walk-in' morning surgeries and appointment-only evening surgeries are now offered.

Appointments and Schedules↗
PubMed1989

Endoscopic palliation of malignant obstructive jaundice.

Patients referred for endoscopic retrograde cholangiopancreatography (ERCP) over a 12 month period who had a diagnosis of malignant obstructive jaundice prior to or confirmed by the procedure were reviewed. Insertion of a biliary endoprosthesis was attempted in 23 out of 26 patients and was successful in 19 (82%). A significant fall in bilirubin was seen in 15 (79%) of those who had a successful procedure. The only early complication was cholangitis in two patients. Late complications were related to occlusion of the endoprosthesis and replacement was required in six patients. Endoscopic palliation of malignant obstructive jaundice is a useful technique and should be considered as the initial procedure in all patients considered to have nonresectable malignancy.

Adult↗
PubMed1987

Permeability of the rat small intestine to carbohydrate probe molecules.

1. Absorption of carbohydrate probe molecules from ligated loops of rat small intestine was studied. Absorption was determined by measuring recovery of molecules in the urine, corrected for incomplete recovery after intravenous injection, and was examined for correlation with several parameters of molecular dimension. 2. Absorption depended on molecular volume rather than relative molecular mass, molecular radius or molecular area. 3. Molecules with a molecular volume below 225 X 10(-3) nm3 were absorbed to a greater extent than larger molecules, and absorption was affected critically by molecular volume, small changes in volume producing considerable variation in absorption. 4. Absorption of larger molecules was not affected by changes in volume within the range 362 X 10(-3)-1128 X 10(-3) nm3. 5. These findings support the concept that there are at least two aqueous diffusion pathways across the intestinal mucosa. small molecules diffusing through a small channel of finite dimension, compatible with a transcellular aqueous pore, whilst large molecules diffuse through a less frequent pathway of considerably larger dimensions.

Animals↗
PubMed1987

Short-term biliary dilatation and stenting in primary sclerosing cholangitis.

Operative biliary dilatation and prolonged percutaneous transhepatic biliary stenting have been useful in the management of primary sclerosing cholangitis, both intrahepatic and extrahepatic biliary strictures regressing after 12-16 months of treatment. We report the results of less prolonged treatment in a further four patients, in whom removal of a percutaneous transhepatic biliary stent 3-11 months after treatment led to an improvement in radiological appearances of the extrahepatic bile ducts, with no discernible effect on intrahepatic disease. Extrahepatic stricture recurred rapidly in one patient stented for only 3 months. Operative biliary dilatation and stenting for 5-11 months may lead to regression of extrahepatic biliary strictures in patients with primary sclerosing cholangitis, whereas intrahepatic disease requires stenting for 12-16 months. Further study is required to determine the applicability of this approach to primary sclerosing cholangitis.

Adult↗
PubMed1987

Polymyositis complicating staphylococcal septicaemia.

Inflammatory polymyositis can be precipitated by acute febrile illness of viral origin, but similar association with pyogenic bacterial illness is not recognised. We describe two cases in which recovery from staphylococcal septicaemia was complicated by a widespread inflammatory myopathy.

Female↗