A follow-up study of patients with homo- and heterotransplantation of the aortic valve.
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Biomedical subjects
Publications and source records attributed to I H Rygg.
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Among 80 patients having aortic valve replacement using a continuous suture technique the occurrence of periprosthetic leak was 8.8%. There is a statistically significant difference in the occurrence of the periprosthetic leak in patients having pure stenosis (o) of combined stenosis and insufficiency, and patients having pure insufficiency (26%). Continuous suture technique reduces cross clamp time and by-pass time significantly but should be used routinely only in stenotic lesions. In pure insufficiency the method of suture should be considered separately in each case. Interrupted suture technique should be used if one or more of the known factors predisposing to perivalvular leak are present.
Fenoterol (a selective beta-2-adrenergic drug) was given intravenously (2 mcg/kg body weight/15 min) to 7 normotensive patients after open-heart surgery in order to study the cardiovascular and respiratory effects. A marked cardiovascular effect was seen without changes in venous or arterial pressure. The increased heart rate (46%) was of sinus or atrial origin; no ventricular arrhythmias were seen. The cardiac index rose by 91%; left and right ventricular stroke work increased by 26% and 54% respectively; systemic and pulmonary vascular resistance decreased by 31% and 23% respectively; arterial oxygen tension decreased from 264 to 205 mm Hg; oxygen consumption rose 31%. No changes occurred in respiratory dynamics, in the total respiratory system of patient and tubes. The cardiovascular effect of fenoterol, without a corresponding increase in end-diastolic filling pressure and resistance against systolic ejection of the left ventricle, as well as the absence of ventricular arrhythmias, indicate that the drug may be useful as a supplement to other sympathomimetic compounds in normal use.